How Viruses Use the VCP/p97 ATPase Molecular Machine
Viruses are obligate intracellular parasites that are dependent on host factors for their replication. One such host protein, p97 or the valosin-containing protein (VCP), is a highly conserved AAA ATPase that facilitates replication of diverse RNA- and DNA-containing viruses. The wide range of cellu...
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doaj-58227ff9d71440c29f34cc4b395518082021-09-26T01:37:57ZengMDPI AGViruses1999-49152021-09-01131881188110.3390/v13091881How Viruses Use the VCP/p97 ATPase Molecular MachinePoulami Das0Jaquelin P. Dudley1Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USADepartment of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USAViruses are obligate intracellular parasites that are dependent on host factors for their replication. One such host protein, p97 or the valosin-containing protein (VCP), is a highly conserved AAA ATPase that facilitates replication of diverse RNA- and DNA-containing viruses. The wide range of cellular functions attributed to this ATPase is consistent with its participation in multiple steps of the virus life cycle from entry and uncoating to viral egress. Studies of VCP/p97 interactions with viruses will provide important information about host processes and cell biology, but also viral strategies that take advantage of these host functions. The critical role of p97 in viral replication might be exploited as a target for development of pan-antiviral drugs that exceed the capability of virus-specific vaccines or therapeutics.https://www.mdpi.com/1999-4915/13/9/1881VCPp97virus replicationERADcellular traffickinguncoating |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Poulami Das Jaquelin P. Dudley |
spellingShingle |
Poulami Das Jaquelin P. Dudley How Viruses Use the VCP/p97 ATPase Molecular Machine Viruses VCP p97 virus replication ERAD cellular trafficking uncoating |
author_facet |
Poulami Das Jaquelin P. Dudley |
author_sort |
Poulami Das |
title |
How Viruses Use the VCP/p97 ATPase Molecular Machine |
title_short |
How Viruses Use the VCP/p97 ATPase Molecular Machine |
title_full |
How Viruses Use the VCP/p97 ATPase Molecular Machine |
title_fullStr |
How Viruses Use the VCP/p97 ATPase Molecular Machine |
title_full_unstemmed |
How Viruses Use the VCP/p97 ATPase Molecular Machine |
title_sort |
how viruses use the vcp/p97 atpase molecular machine |
publisher |
MDPI AG |
series |
Viruses |
issn |
1999-4915 |
publishDate |
2021-09-01 |
description |
Viruses are obligate intracellular parasites that are dependent on host factors for their replication. One such host protein, p97 or the valosin-containing protein (VCP), is a highly conserved AAA ATPase that facilitates replication of diverse RNA- and DNA-containing viruses. The wide range of cellular functions attributed to this ATPase is consistent with its participation in multiple steps of the virus life cycle from entry and uncoating to viral egress. Studies of VCP/p97 interactions with viruses will provide important information about host processes and cell biology, but also viral strategies that take advantage of these host functions. The critical role of p97 in viral replication might be exploited as a target for development of pan-antiviral drugs that exceed the capability of virus-specific vaccines or therapeutics. |
topic |
VCP p97 virus replication ERAD cellular trafficking uncoating |
url |
https://www.mdpi.com/1999-4915/13/9/1881 |
work_keys_str_mv |
AT poulamidas howvirusesusethevcpp97atpasemolecularmachine AT jaquelinpdudley howvirusesusethevcpp97atpasemolecularmachine |
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