Prevalence of total hepatitis A antibody among 5 to 7 years old children and their mothers in Cambodia
Abstract This study determined the prevalence of total hepatitis A antibody (anti-HAV) among 5–7 years old children and their mothers in the whole Cambodia, using a nationwide study, and examined the differences between the two cohorts. A total of 4535 dried blood spot-driven (DBS) samples (2021 mot...
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doaj-58293f29ef8f4732baef2f19b30e39be2021-03-11T12:22:32ZengNature Publishing GroupScientific Reports2045-23222021-02-011111710.1038/s41598-021-83710-2Prevalence of total hepatitis A antibody among 5 to 7 years old children and their mothers in CambodiaShintaro Nagashima0Ko Ko1Chikako Yamamoto2E. Bunthen3Serge Ouoba4Channarena Chuon5Masayuki Ohisa6Aya Sugiyama7Tomoyuki Akita8Md. Shafiqul Hossain9Vichit Ork10Bunsoth Mao11Junko Tanaka12Department of Epidemiology, Infectious Disease Control and Prevention, Hiroshima University Graduate School of Biomedical and Health SciencesDepartment of Epidemiology, Infectious Disease Control and Prevention, Hiroshima University Graduate School of Biomedical and Health SciencesDepartment of Epidemiology, Infectious Disease Control and Prevention, Hiroshima University Graduate School of Biomedical and Health SciencesDepartment of Epidemiology, Infectious Disease Control and Prevention, Hiroshima University Graduate School of Biomedical and Health SciencesDepartment of Epidemiology, Infectious Disease Control and Prevention, Hiroshima University Graduate School of Biomedical and Health SciencesDepartment of Epidemiology, Infectious Disease Control and Prevention, Hiroshima University Graduate School of Biomedical and Health SciencesDepartment of Epidemiology, Infectious Disease Control and Prevention, Hiroshima University Graduate School of Biomedical and Health SciencesDepartment of Epidemiology, Infectious Disease Control and Prevention, Hiroshima University Graduate School of Biomedical and Health SciencesDepartment of Epidemiology, Infectious Disease Control and Prevention, Hiroshima University Graduate School of Biomedical and Health SciencesExpanded Programme On Immunization, World Health Organization Country OfficeNational Immunization Programme, Ministry of HealthUniversity of Health SciencesDepartment of Epidemiology, Infectious Disease Control and Prevention, Hiroshima University Graduate School of Biomedical and Health SciencesAbstract This study determined the prevalence of total hepatitis A antibody (anti-HAV) among 5–7 years old children and their mothers in the whole Cambodia, using a nationwide study, and examined the differences between the two cohorts. A total of 4535 dried blood spot-driven (DBS) samples (2021 mothers and their 2514 children of 5–7 years old) and the concomitant 922 whole blood samples (subset of the whole participants) were collected using a multistage random sampling strategy throughout Cambodia in 2017. Total anti-HAV was detected using the chemiluminescence enzyme immunoassay method. Compared to gold standard whole blood samples, the sensitivity and specificity of DBS mediated anti-HAV detection were 94.8% and 98%, respectively. Total anti-HAV prevalence among mothers was 91.2% (95%CI: 90.0–92.5%), and that of their children was 31.5% (95%CI: 29.7–33.3%). In our study, the low prevalence of total anti-HAV among children indicates the country’s improvement of safe water and food supply, hygiene and sanitation. If the hygiene and sanitation are consistently improved in Cambodia, the prevalence might be no longer increased when the children become adults.https://doi.org/10.1038/s41598-021-83710-2 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Shintaro Nagashima Ko Ko Chikako Yamamoto E. Bunthen Serge Ouoba Channarena Chuon Masayuki Ohisa Aya Sugiyama Tomoyuki Akita Md. Shafiqul Hossain Vichit Ork Bunsoth Mao Junko Tanaka |
spellingShingle |
Shintaro Nagashima Ko Ko Chikako Yamamoto E. Bunthen Serge Ouoba Channarena Chuon Masayuki Ohisa Aya Sugiyama Tomoyuki Akita Md. Shafiqul Hossain Vichit Ork Bunsoth Mao Junko Tanaka Prevalence of total hepatitis A antibody among 5 to 7 years old children and their mothers in Cambodia Scientific Reports |
author_facet |
Shintaro Nagashima Ko Ko Chikako Yamamoto E. Bunthen Serge Ouoba Channarena Chuon Masayuki Ohisa Aya Sugiyama Tomoyuki Akita Md. Shafiqul Hossain Vichit Ork Bunsoth Mao Junko Tanaka |
author_sort |
Shintaro Nagashima |
title |
Prevalence of total hepatitis A antibody among 5 to 7 years old children and their mothers in Cambodia |
title_short |
Prevalence of total hepatitis A antibody among 5 to 7 years old children and their mothers in Cambodia |
title_full |
Prevalence of total hepatitis A antibody among 5 to 7 years old children and their mothers in Cambodia |
title_fullStr |
Prevalence of total hepatitis A antibody among 5 to 7 years old children and their mothers in Cambodia |
title_full_unstemmed |
Prevalence of total hepatitis A antibody among 5 to 7 years old children and their mothers in Cambodia |
title_sort |
prevalence of total hepatitis a antibody among 5 to 7 years old children and their mothers in cambodia |
publisher |
Nature Publishing Group |
series |
Scientific Reports |
issn |
2045-2322 |
publishDate |
2021-02-01 |
description |
Abstract This study determined the prevalence of total hepatitis A antibody (anti-HAV) among 5–7 years old children and their mothers in the whole Cambodia, using a nationwide study, and examined the differences between the two cohorts. A total of 4535 dried blood spot-driven (DBS) samples (2021 mothers and their 2514 children of 5–7 years old) and the concomitant 922 whole blood samples (subset of the whole participants) were collected using a multistage random sampling strategy throughout Cambodia in 2017. Total anti-HAV was detected using the chemiluminescence enzyme immunoassay method. Compared to gold standard whole blood samples, the sensitivity and specificity of DBS mediated anti-HAV detection were 94.8% and 98%, respectively. Total anti-HAV prevalence among mothers was 91.2% (95%CI: 90.0–92.5%), and that of their children was 31.5% (95%CI: 29.7–33.3%). In our study, the low prevalence of total anti-HAV among children indicates the country’s improvement of safe water and food supply, hygiene and sanitation. If the hygiene and sanitation are consistently improved in Cambodia, the prevalence might be no longer increased when the children become adults. |
url |
https://doi.org/10.1038/s41598-021-83710-2 |
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