A Pilot Study of the Effect of Deployment on the Gut Microbiome and Traveler’s Diarrhea Susceptibility
Traveler’s diarrhea (TD) is a recurrent and significant issue for many travelers including the military. While many known enteric pathogens exist that are causative agents of diarrhea, our gut microbiome may also play a role in TD susceptibility. To this end, we conducted a pilot study of the microb...
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2020-12-01
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doaj-583ec325f5fd46f5a32fd2c57e7cef7c2020-12-15T07:09:50ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882020-12-011010.3389/fcimb.2020.589297589297A Pilot Study of the Effect of Deployment on the Gut Microbiome and Traveler’s Diarrhea SusceptibilityBlake W. Stamps0Blake W. Stamps1Wanda J. Lyon2Adam P. Irvin3Nancy Kelley-Loughnane4Michael S. Goodson5711th Human Performance Wing, Airman Systems Directorate, Air Force Research Laboratory, Wright-Patterson AFB, OH, United StatesIntegrative Health and Performance Sciences Division, UES Inc., Dayton, OH, United States711th Human Performance Wing, Airman Systems Directorate, Air Force Research Laboratory, Wright-Patterson AFB, OH, United States711th Human Performance Wing, Airman Systems Directorate, Air Force Research Laboratory, Wright-Patterson AFB, OH, United States711th Human Performance Wing, Airman Systems Directorate, Air Force Research Laboratory, Wright-Patterson AFB, OH, United States711th Human Performance Wing, Airman Systems Directorate, Air Force Research Laboratory, Wright-Patterson AFB, OH, United StatesTraveler’s diarrhea (TD) is a recurrent and significant issue for many travelers including the military. While many known enteric pathogens exist that are causative agents of diarrhea, our gut microbiome may also play a role in TD susceptibility. To this end, we conducted a pilot study of the microbiome of warfighters prior to- and after deployment overseas to identify marker taxa relevant to TD. This initial study utilized full-length 16S rRNA gene sequencing to provide additional taxonomic resolution toward identifying predictive taxa.16S rRNA analyses of pre- and post-deployment fecal samples identified multiple marker taxa as significantly differentially abundant in subjects that reported diarrhea, including Weissella, Butyrivibrio, Corynebacterium, uncultivated Erysipelotrichaceae, Jeotgallibaca, unclassified Ktedonobacteriaceae, Leptolinea, and uncultivated Ruminiococcaceae. The ability to identify TD risk prior to travel will inform prevention and mitigation strategies to influence diarrhea susceptibility while traveling.https://www.frontiersin.org/articles/10.3389/fcimb.2020.589297/fullgut microbiome16S rRNA genediarrheadysbiosisdeployment |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Blake W. Stamps Blake W. Stamps Wanda J. Lyon Adam P. Irvin Nancy Kelley-Loughnane Michael S. Goodson |
spellingShingle |
Blake W. Stamps Blake W. Stamps Wanda J. Lyon Adam P. Irvin Nancy Kelley-Loughnane Michael S. Goodson A Pilot Study of the Effect of Deployment on the Gut Microbiome and Traveler’s Diarrhea Susceptibility Frontiers in Cellular and Infection Microbiology gut microbiome 16S rRNA gene diarrhea dysbiosis deployment |
author_facet |
Blake W. Stamps Blake W. Stamps Wanda J. Lyon Adam P. Irvin Nancy Kelley-Loughnane Michael S. Goodson |
author_sort |
Blake W. Stamps |
title |
A Pilot Study of the Effect of Deployment on the Gut Microbiome and Traveler’s Diarrhea Susceptibility |
title_short |
A Pilot Study of the Effect of Deployment on the Gut Microbiome and Traveler’s Diarrhea Susceptibility |
title_full |
A Pilot Study of the Effect of Deployment on the Gut Microbiome and Traveler’s Diarrhea Susceptibility |
title_fullStr |
A Pilot Study of the Effect of Deployment on the Gut Microbiome and Traveler’s Diarrhea Susceptibility |
title_full_unstemmed |
A Pilot Study of the Effect of Deployment on the Gut Microbiome and Traveler’s Diarrhea Susceptibility |
title_sort |
pilot study of the effect of deployment on the gut microbiome and traveler’s diarrhea susceptibility |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Cellular and Infection Microbiology |
issn |
2235-2988 |
publishDate |
2020-12-01 |
description |
Traveler’s diarrhea (TD) is a recurrent and significant issue for many travelers including the military. While many known enteric pathogens exist that are causative agents of diarrhea, our gut microbiome may also play a role in TD susceptibility. To this end, we conducted a pilot study of the microbiome of warfighters prior to- and after deployment overseas to identify marker taxa relevant to TD. This initial study utilized full-length 16S rRNA gene sequencing to provide additional taxonomic resolution toward identifying predictive taxa.16S rRNA analyses of pre- and post-deployment fecal samples identified multiple marker taxa as significantly differentially abundant in subjects that reported diarrhea, including Weissella, Butyrivibrio, Corynebacterium, uncultivated Erysipelotrichaceae, Jeotgallibaca, unclassified Ktedonobacteriaceae, Leptolinea, and uncultivated Ruminiococcaceae. The ability to identify TD risk prior to travel will inform prevention and mitigation strategies to influence diarrhea susceptibility while traveling. |
topic |
gut microbiome 16S rRNA gene diarrhea dysbiosis deployment |
url |
https://www.frontiersin.org/articles/10.3389/fcimb.2020.589297/full |
work_keys_str_mv |
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