PPARs as Metabolic Regulators in the Liver: Lessons from Liver-Specific PPAR-Null Mice

Peroxisome proliferator-activated receptor (PPAR) α, β/δ, and γ modulate lipid homeostasis. PPARα regulates lipid metabolism in the liver, the organ that largely controls whole-body nutrient/energy homeostasis, and its abnormalities may lead to hepatic st...

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Main Authors:	Yaping Wang, Takero Nakajima, Frank J. Gonzalez, Naoki Tanaka
Format:	Article
Language:	English
Published:	MDPI AG 2020-03-01
Series:	International Journal of Molecular Sciences
Subjects:	ppar nafld nash insulin resistance liver fibrosis
Online Access:	https://www.mdpi.com/1422-0067/21/6/2061

id	doaj-58432ea6426e43edb330c23f95f5f7c4
record_format	Article
spelling	doaj-58432ea6426e43edb330c23f95f5f7c42020-11-25T01:48:28ZengMDPI AGInternational Journal of Molecular Sciences1422-00672020-03-01216206110.3390/ijms21062061ijms21062061PPARs as Metabolic Regulators in the Liver: Lessons from Liver-Specific PPAR-Null MiceYaping Wang0Takero Nakajima1Frank J. Gonzalez2Naoki Tanaka3Department of Metabolic Regulation, Shinshu University School of Medicine, Matsumoto, Nagano 390-8621, JapanDepartment of Metabolic Regulation, Shinshu University School of Medicine, Matsumoto, Nagano 390-8621, JapanLaboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USADepartment of Metabolic Regulation, Shinshu University School of Medicine, Matsumoto, Nagano 390-8621, JapanPeroxisome proliferator-activated receptor (PPAR) α, β/δ, and γ modulate lipid homeostasis. PPARα regulates lipid metabolism in the liver, the organ that largely controls whole-body nutrient/energy homeostasis, and its abnormalities may lead to hepatic steatosis, steatohepatitis, steatofibrosis, and liver cancer. PPARβ/δ promotes fatty acid β-oxidation largely in extrahepatic organs, and PPARγ stores triacylglycerol in adipocytes. Investigations using liver-specific PPAR-disrupted mice have revealed major but distinct contributions of the three PPARs in the liver. This review summarizes the findings of liver-specific PPAR-null mice and discusses the role of PPARs in the liver.https://www.mdpi.com/1422-0067/21/6/2061pparnafldnashinsulin resistanceliver fibrosis
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Yaping Wang Takero Nakajima Frank J. Gonzalez Naoki Tanaka
spellingShingle	Yaping Wang Takero Nakajima Frank J. Gonzalez Naoki Tanaka PPARs as Metabolic Regulators in the Liver: Lessons from Liver-Specific PPAR-Null Mice International Journal of Molecular Sciences ppar nafld nash insulin resistance liver fibrosis
author_facet	Yaping Wang Takero Nakajima Frank J. Gonzalez Naoki Tanaka
author_sort	Yaping Wang
title	PPARs as Metabolic Regulators in the Liver: Lessons from Liver-Specific PPAR-Null Mice
title_short	PPARs as Metabolic Regulators in the Liver: Lessons from Liver-Specific PPAR-Null Mice
title_full	PPARs as Metabolic Regulators in the Liver: Lessons from Liver-Specific PPAR-Null Mice
title_fullStr	PPARs as Metabolic Regulators in the Liver: Lessons from Liver-Specific PPAR-Null Mice
title_full_unstemmed	PPARs as Metabolic Regulators in the Liver: Lessons from Liver-Specific PPAR-Null Mice
title_sort	ppars as metabolic regulators in the liver: lessons from liver-specific ppar-null mice
publisher	MDPI AG
series	International Journal of Molecular Sciences
issn	1422-0067
publishDate	2020-03-01
description	Peroxisome proliferator-activated receptor (PPAR) α, β/δ, and γ modulate lipid homeostasis. PPARα regulates lipid metabolism in the liver, the organ that largely controls whole-body nutrient/energy homeostasis, and its abnormalities may lead to hepatic steatosis, steatohepatitis, steatofibrosis, and liver cancer. PPARβ/δ promotes fatty acid β-oxidation largely in extrahepatic organs, and PPARγ stores triacylglycerol in adipocytes. Investigations using liver-specific PPAR-disrupted mice have revealed major but distinct contributions of the three PPARs in the liver. This review summarizes the findings of liver-specific PPAR-null mice and discusses the role of PPARs in the liver.
topic	ppar nafld nash insulin resistance liver fibrosis
url	https://www.mdpi.com/1422-0067/21/6/2061
work_keys_str_mv	AT yapingwang pparsasmetabolicregulatorsintheliverlessonsfromliverspecificpparnullmice AT takeronakajima pparsasmetabolicregulatorsintheliverlessonsfromliverspecificpparnullmice AT frankjgonzalez pparsasmetabolicregulatorsintheliverlessonsfromliverspecificpparnullmice AT naokitanaka pparsasmetabolicregulatorsintheliverlessonsfromliverspecificpparnullmice
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PPARs as Metabolic Regulators in the Liver: Lessons from Liver-Specific PPAR-Null Mice

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