Effect of Hypoxia-Inducible Factor 1α on Early Healing in Extraction Sockets
The aim of the present study was to investigate the effect of hypoxia-inducible factor 1α (HIF1A) on the early healing (4 weeks) of extraction sockets exhibiting partial loss of the labial bone. Two extraction sockets of the maxillary incisors from each of six dogs were assigned to two treatment mod...
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Series: | BioMed Research International |
Online Access: | http://dx.doi.org/10.1155/2018/8210637 |
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doaj-584e20a2c99a48518211b95ba3646a3b2020-11-25T00:03:45ZengHindawi LimitedBioMed Research International2314-61332314-61412018-01-01201810.1155/2018/82106378210637Effect of Hypoxia-Inducible Factor 1α on Early Healing in Extraction SocketsHyun-Chang Lim0Daniel S. Thoma1Mijeong Jeon2Je-Seon Song3Sang-Kyou Lee4Ui-Won Jung5Clinic for Fixed and Removable Prosthodontics and Dental Material Science, University of Zurich, Zurich, SwitzerlandClinic for Fixed and Removable Prosthodontics and Dental Material Science, University of Zurich, Zurich, SwitzerlandDepartment of Pediatric Dentistry, Oral Science Research Center, College of Dentistry, Yonsei University, Seoul, Republic of KoreaDepartment of Pediatric Dentistry, Oral Science Research Center, College of Dentistry, Yonsei University, Seoul, Republic of KoreaDepartment of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul, Republic of KoreaDepartment of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University, Seoul, Republic of KoreaThe aim of the present study was to investigate the effect of hypoxia-inducible factor 1α (HIF1A) on the early healing (4 weeks) of extraction sockets exhibiting partial loss of the labial bone. Two extraction sockets of the maxillary incisors from each of six dogs were assigned to two treatment modalities: deproteinized bovine bone mineral (i) with 10% collagen (DBBM-C) soaked with HIF1A and covered by a collagen membrane (CM) (HIF group) or (ii) treated with DBBM-C only and covered by a CM (control group). Microcomputed tomography revealed some degree of collapse of the labial contour. The totally augmented volume and new bone volume did not differ significantly between two groups (P>0.05). The histological analysis revealed that the apical area of the socket was mostly filled with newly formed bone, while there was less newly formed bone in the coronal area and incomplete cortex formation. The histomorphometric analysis revealed that the area of newly formed bone was significantly larger in the HIF group than the control group (12.16±3.04 versus 9.48±2.01 mm2, P<0.05), while there was no significant intergroup difference in the total augmented area. In conclusion, even though DBBM-C soaked with HIF1A enhanced histomorphometric bone formation, this intervention did not demonstrate superiority in preventing ridge shrinkage compared to DBBM-C alone. Clinical relevance of these findings should be further studied.http://dx.doi.org/10.1155/2018/8210637 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hyun-Chang Lim Daniel S. Thoma Mijeong Jeon Je-Seon Song Sang-Kyou Lee Ui-Won Jung |
spellingShingle |
Hyun-Chang Lim Daniel S. Thoma Mijeong Jeon Je-Seon Song Sang-Kyou Lee Ui-Won Jung Effect of Hypoxia-Inducible Factor 1α on Early Healing in Extraction Sockets BioMed Research International |
author_facet |
Hyun-Chang Lim Daniel S. Thoma Mijeong Jeon Je-Seon Song Sang-Kyou Lee Ui-Won Jung |
author_sort |
Hyun-Chang Lim |
title |
Effect of Hypoxia-Inducible Factor 1α on Early Healing in Extraction Sockets |
title_short |
Effect of Hypoxia-Inducible Factor 1α on Early Healing in Extraction Sockets |
title_full |
Effect of Hypoxia-Inducible Factor 1α on Early Healing in Extraction Sockets |
title_fullStr |
Effect of Hypoxia-Inducible Factor 1α on Early Healing in Extraction Sockets |
title_full_unstemmed |
Effect of Hypoxia-Inducible Factor 1α on Early Healing in Extraction Sockets |
title_sort |
effect of hypoxia-inducible factor 1α on early healing in extraction sockets |
publisher |
Hindawi Limited |
series |
BioMed Research International |
issn |
2314-6133 2314-6141 |
publishDate |
2018-01-01 |
description |
The aim of the present study was to investigate the effect of hypoxia-inducible factor 1α (HIF1A) on the early healing (4 weeks) of extraction sockets exhibiting partial loss of the labial bone. Two extraction sockets of the maxillary incisors from each of six dogs were assigned to two treatment modalities: deproteinized bovine bone mineral (i) with 10% collagen (DBBM-C) soaked with HIF1A and covered by a collagen membrane (CM) (HIF group) or (ii) treated with DBBM-C only and covered by a CM (control group). Microcomputed tomography revealed some degree of collapse of the labial contour. The totally augmented volume and new bone volume did not differ significantly between two groups (P>0.05). The histological analysis revealed that the apical area of the socket was mostly filled with newly formed bone, while there was less newly formed bone in the coronal area and incomplete cortex formation. The histomorphometric analysis revealed that the area of newly formed bone was significantly larger in the HIF group than the control group (12.16±3.04 versus 9.48±2.01 mm2, P<0.05), while there was no significant intergroup difference in the total augmented area. In conclusion, even though DBBM-C soaked with HIF1A enhanced histomorphometric bone formation, this intervention did not demonstrate superiority in preventing ridge shrinkage compared to DBBM-C alone. Clinical relevance of these findings should be further studied. |
url |
http://dx.doi.org/10.1155/2018/8210637 |
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