De novo Portal Vein Thrombosis in Non-Cirrhotic Non-Alcoholic Fatty Liver Disease: A 9-Year Prospective Cohort Study
Background and Aims: Approximately 30–40% of portal vein thrombosis (PVT) remains of unknown origin. The association between non-alcoholic fatty liver disease (NAFLD) and PVT is a matter of debate. This study aimed to investigate the association between PVT and NAFLD.Methods: We included 94 out of 1...
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doaj-585c08c33c494c7b8b885a857362b06c2021-04-29T11:25:29ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2021-04-01810.3389/fmed.2021.650818650818De novo Portal Vein Thrombosis in Non-Cirrhotic Non-Alcoholic Fatty Liver Disease: A 9-Year Prospective Cohort StudyAhmed Abdel-Razik0Nasser Mousa1Walaa Shabana2Ahmed H. Yassen3Mostafa Abdelsalam4Mohamed M. Wahba5Eman Mohamed Helmy6Ahmed M. Tawfik7Khaled Zalata8Ahmad S. Hasan9Rania Elhelaly10Rasha Elzehery11Aya Ahmed Fathy12Niveen El-Wakeel13Waleed Eldars14Tropical Medicine Department, Faculty of Medicine, Mansoura University, Mansoura, EgyptTropical Medicine Department, Faculty of Medicine, Mansoura University, Mansoura, EgyptTropical Medicine Department, Faculty of Medicine, Mansoura University, Mansoura, EgyptTropical Medicine Department, Faculty of Medicine, Mansoura University, Mansoura, EgyptNephrology and Dialysis Unit, Internal Medicine Department, Faculty of Medicine, Mansoura University, Mansoura, EgyptNephrology and Dialysis Unit, Internal Medicine Department, Faculty of Medicine, Mansoura University, Mansoura, EgyptDiagnostic & Interventional Radiology Department, Faculty of Medicine, Mansoura University, Mansoura, EgyptDiagnostic & Interventional Radiology Department, Faculty of Medicine, Mansoura University, Mansoura, EgyptPathology Department, Faculty of Medicine, Mansoura University, Mansoura, EgyptClinical Pathology Department, Faculty of Medicine, Mansoura University, Mansoura, EgyptClinical Pathology Department, Faculty of Medicine, Mansoura University, Mansoura, EgyptClinical Pathology Department, Faculty of Medicine, Mansoura University, Mansoura, EgyptPublic Health and Community Department, Faculty of Medicine, Mansoura University, Mansoura, EgyptMedical Microbiology and Immunology Department, Faculty of Medicine, Mansoura University, Mansoura, EgyptMedical Microbiology and Immunology Department, Faculty of Medicine, Mansoura University, Mansoura, EgyptBackground and Aims: Approximately 30–40% of portal vein thrombosis (PVT) remains of unknown origin. The association between non-alcoholic fatty liver disease (NAFLD) and PVT is a matter of debate. This study aimed to investigate the association between PVT and NAFLD.Methods: We included 94 out of 105 consecutive NAFLD patients in this prospective cohort study in addition to 94 from the healthy control group. We evaluated biochemical, clinical, immunological, and histopathological parameters; waist circumference (WC); leptin; adiponectin; and leptin/adiponectin ratio (LAR) for all participants at baseline and every 3 years thereafter. We described the characteristics of participants at baseline and showed individual WC, LAR, and PVT characteristics. Potential parameters to predict PVT development within 9 years were determined.Results: PVT developed in eight (8.5%) patients, mainly in the portal trunk. Univariate analysis showed three PVT-associated factors: diabetes mellitus (P = 0.013), WC (P < 0.001), and LAR (P = 0.002). After adjusting multiple confounding variables, the multivariate model showed that the only significant variables were WC and LAR. By applying the receiver operating characteristic curve, WC had 98.8% specificity, 87.5% sensitivity, and 0.894 area under the curve (AUC) for prediction of PVT (P < 0.001) at cutoff values of > 105 cm. In comparison, LAR had 60.5% specificity, 87.5% sensitivity, and 0.805 AUC for PVT prediction (P < 0.001) at cutoff values of >7.5.Conclusions: This study suggests that increased central obesity and LAR were independently associated with PVT development in non-cirrhotic NAFLD patients, and they should be considered risk factors that may participate in PVT multifactorial pathogenesis.https://www.frontiersin.org/articles/10.3389/fmed.2021.650818/fulladiponectinleptinleptin/adiponectin ratioNAFLDportal vein thrombosiswaist circumference |
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language |
English |
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Article |
sources |
DOAJ |
author |
Ahmed Abdel-Razik Nasser Mousa Walaa Shabana Ahmed H. Yassen Mostafa Abdelsalam Mohamed M. Wahba Eman Mohamed Helmy Ahmed M. Tawfik Khaled Zalata Ahmad S. Hasan Rania Elhelaly Rasha Elzehery Aya Ahmed Fathy Niveen El-Wakeel Waleed Eldars |
spellingShingle |
Ahmed Abdel-Razik Nasser Mousa Walaa Shabana Ahmed H. Yassen Mostafa Abdelsalam Mohamed M. Wahba Eman Mohamed Helmy Ahmed M. Tawfik Khaled Zalata Ahmad S. Hasan Rania Elhelaly Rasha Elzehery Aya Ahmed Fathy Niveen El-Wakeel Waleed Eldars De novo Portal Vein Thrombosis in Non-Cirrhotic Non-Alcoholic Fatty Liver Disease: A 9-Year Prospective Cohort Study Frontiers in Medicine adiponectin leptin leptin/adiponectin ratio NAFLD portal vein thrombosis waist circumference |
author_facet |
Ahmed Abdel-Razik Nasser Mousa Walaa Shabana Ahmed H. Yassen Mostafa Abdelsalam Mohamed M. Wahba Eman Mohamed Helmy Ahmed M. Tawfik Khaled Zalata Ahmad S. Hasan Rania Elhelaly Rasha Elzehery Aya Ahmed Fathy Niveen El-Wakeel Waleed Eldars |
author_sort |
Ahmed Abdel-Razik |
title |
De novo Portal Vein Thrombosis in Non-Cirrhotic Non-Alcoholic Fatty Liver Disease: A 9-Year Prospective Cohort Study |
title_short |
De novo Portal Vein Thrombosis in Non-Cirrhotic Non-Alcoholic Fatty Liver Disease: A 9-Year Prospective Cohort Study |
title_full |
De novo Portal Vein Thrombosis in Non-Cirrhotic Non-Alcoholic Fatty Liver Disease: A 9-Year Prospective Cohort Study |
title_fullStr |
De novo Portal Vein Thrombosis in Non-Cirrhotic Non-Alcoholic Fatty Liver Disease: A 9-Year Prospective Cohort Study |
title_full_unstemmed |
De novo Portal Vein Thrombosis in Non-Cirrhotic Non-Alcoholic Fatty Liver Disease: A 9-Year Prospective Cohort Study |
title_sort |
de novo portal vein thrombosis in non-cirrhotic non-alcoholic fatty liver disease: a 9-year prospective cohort study |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Medicine |
issn |
2296-858X |
publishDate |
2021-04-01 |
description |
Background and Aims: Approximately 30–40% of portal vein thrombosis (PVT) remains of unknown origin. The association between non-alcoholic fatty liver disease (NAFLD) and PVT is a matter of debate. This study aimed to investigate the association between PVT and NAFLD.Methods: We included 94 out of 105 consecutive NAFLD patients in this prospective cohort study in addition to 94 from the healthy control group. We evaluated biochemical, clinical, immunological, and histopathological parameters; waist circumference (WC); leptin; adiponectin; and leptin/adiponectin ratio (LAR) for all participants at baseline and every 3 years thereafter. We described the characteristics of participants at baseline and showed individual WC, LAR, and PVT characteristics. Potential parameters to predict PVT development within 9 years were determined.Results: PVT developed in eight (8.5%) patients, mainly in the portal trunk. Univariate analysis showed three PVT-associated factors: diabetes mellitus (P = 0.013), WC (P < 0.001), and LAR (P = 0.002). After adjusting multiple confounding variables, the multivariate model showed that the only significant variables were WC and LAR. By applying the receiver operating characteristic curve, WC had 98.8% specificity, 87.5% sensitivity, and 0.894 area under the curve (AUC) for prediction of PVT (P < 0.001) at cutoff values of > 105 cm. In comparison, LAR had 60.5% specificity, 87.5% sensitivity, and 0.805 AUC for PVT prediction (P < 0.001) at cutoff values of >7.5.Conclusions: This study suggests that increased central obesity and LAR were independently associated with PVT development in non-cirrhotic NAFLD patients, and they should be considered risk factors that may participate in PVT multifactorial pathogenesis. |
topic |
adiponectin leptin leptin/adiponectin ratio NAFLD portal vein thrombosis waist circumference |
url |
https://www.frontiersin.org/articles/10.3389/fmed.2021.650818/full |
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