Model systems for studying cell adhesion and biomimetic actin networks
Many cellular processes, such as migration, proliferation, wound healing and tumor progression are based on cell adhesion. Amongst different cell adhesion molecules, the integrin receptors play a very significant role. Over the past decades the function and signalling of various such integrins have...
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doaj-58636c4e55394993bb193ba774066be82020-11-24T21:50:10ZengBeilstein-InstitutBeilstein Journal of Nanotechnology2190-42862014-08-01511193120210.3762/bjnano.5.1312190-4286-5-131Model systems for studying cell adhesion and biomimetic actin networksDorothea Brüggemann0Johannes P. Frohnmayer1Joachim P. Spatz2Department of New Materials and Biosystems, Max Planck Institute for Intelligent Systems, Heisenbergstr. 3, D-70569 Stuttgart, GermanyDepartment of New Materials and Biosystems, Max Planck Institute for Intelligent Systems, Heisenbergstr. 3, D-70569 Stuttgart, GermanyDepartment of New Materials and Biosystems, Max Planck Institute for Intelligent Systems, Heisenbergstr. 3, D-70569 Stuttgart, GermanyMany cellular processes, such as migration, proliferation, wound healing and tumor progression are based on cell adhesion. Amongst different cell adhesion molecules, the integrin receptors play a very significant role. Over the past decades the function and signalling of various such integrins have been studied by incorporating the proteins into lipid membranes. These proteolipid structures lay the foundation for the development of artificial cells, which are able to adhere to substrates. To build biomimetic models for studying cell shape and spreading, actin networks can be incorporated into lipid vesicles, too. We here review the mechanisms of integrin-mediated cell adhesion and recent advances in the field of minimal cells towards synthetic adhesion. We focus on reconstituting integrins into lipid structures for mimicking cell adhesion and on the incorporation of actin networks and talin into model cells.https://doi.org/10.3762/bjnano.5.131actin networkcell adhesiongiant unilamellar vesicleintegrinlipid bilayersynthetic cellprotein reconstitutiontalin |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Dorothea Brüggemann Johannes P. Frohnmayer Joachim P. Spatz |
spellingShingle |
Dorothea Brüggemann Johannes P. Frohnmayer Joachim P. Spatz Model systems for studying cell adhesion and biomimetic actin networks Beilstein Journal of Nanotechnology actin network cell adhesion giant unilamellar vesicle integrin lipid bilayer synthetic cell protein reconstitution talin |
author_facet |
Dorothea Brüggemann Johannes P. Frohnmayer Joachim P. Spatz |
author_sort |
Dorothea Brüggemann |
title |
Model systems for studying cell adhesion and biomimetic actin networks |
title_short |
Model systems for studying cell adhesion and biomimetic actin networks |
title_full |
Model systems for studying cell adhesion and biomimetic actin networks |
title_fullStr |
Model systems for studying cell adhesion and biomimetic actin networks |
title_full_unstemmed |
Model systems for studying cell adhesion and biomimetic actin networks |
title_sort |
model systems for studying cell adhesion and biomimetic actin networks |
publisher |
Beilstein-Institut |
series |
Beilstein Journal of Nanotechnology |
issn |
2190-4286 |
publishDate |
2014-08-01 |
description |
Many cellular processes, such as migration, proliferation, wound healing and tumor progression are based on cell adhesion. Amongst different cell adhesion molecules, the integrin receptors play a very significant role. Over the past decades the function and signalling of various such integrins have been studied by incorporating the proteins into lipid membranes. These proteolipid structures lay the foundation for the development of artificial cells, which are able to adhere to substrates. To build biomimetic models for studying cell shape and spreading, actin networks can be incorporated into lipid vesicles, too. We here review the mechanisms of integrin-mediated cell adhesion and recent advances in the field of minimal cells towards synthetic adhesion. We focus on reconstituting integrins into lipid structures for mimicking cell adhesion and on the incorporation of actin networks and talin into model cells. |
topic |
actin network cell adhesion giant unilamellar vesicle integrin lipid bilayer synthetic cell protein reconstitution talin |
url |
https://doi.org/10.3762/bjnano.5.131 |
work_keys_str_mv |
AT dorotheabruggemann modelsystemsforstudyingcelladhesionandbiomimeticactinnetworks AT johannespfrohnmayer modelsystemsforstudyingcelladhesionandbiomimeticactinnetworks AT joachimpspatz modelsystemsforstudyingcelladhesionandbiomimeticactinnetworks |
_version_ |
1725884850030772224 |