The Impact of Nerve Involvement on the Prognosis of Gastric Cancer Patients with Curative Gastrectomy: An International Multicenter Analysis
Background. Several studies have been conducted to investigate the association between the presence of perineural invasion (PNI) and overall survival (OS) of gastric cancer (GC) patients who underwent curative resection, but no consensus has been reached. This study is aimed at determining the progn...
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2021-01-01
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Online Access: | http://dx.doi.org/10.1155/2021/8870562 |
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doaj-5866fe300161410d86898a86aa7279182021-05-24T00:15:41ZengHindawi LimitedDisease Markers1875-86302021-01-01202110.1155/2021/8870562The Impact of Nerve Involvement on the Prognosis of Gastric Cancer Patients with Curative Gastrectomy: An International Multicenter AnalysisKun Yang0Yu-Qing Dan1Yoon Young Choi2Zong-Guang Zhou3Woo Jin Hyung4Jian-Kun Hu5Sung Hoon Noh6Department of Gastrointestinal SurgeryWest China School of MedicineDepartment of SurgeryDepartment of Gastrointestinal SurgeryDepartment of SurgeryDepartment of Gastrointestinal SurgeryDepartment of SurgeryBackground. Several studies have been conducted to investigate the association between the presence of perineural invasion (PNI) and overall survival (OS) of gastric cancer (GC) patients who underwent curative resection, but no consensus has been reached. This study is aimed at determining the prognostic significance of PNI in gastric cancer. Study Design. The data of 2969 patients with gastric cancer and who had undergone curative gastrectomy from 2006 to 2010 in two high-volume hospitals of China and Korea were retrospectively analyzed. PNI positivity was identified when carcinoma cells were found to infiltrate into the perineurium or neural fascicles. The relationships between PNI and other clinicopathological factors were evaluated, and survival analyses were performed. Results. The presence of PNI was detected in 1055 of the 2969 patients (35.5%). Nationality, age, tumor location, size of tumor, differentiation of the tumor, pT stage, pN stage, lymphatic invasion, and vascular invasion had been associated with PNI positivity. The mean survival time of patients with and without PNI was 62.5 months and 87.3 months, respectively (P<0.001). However, the presence of PNI was not an independent prognostic factor for gastric cancer, except for patients in stage III (P=0.037, hazard ratio: 1.21, 95% confidence interval: 1.01-1.44). Conclusion. PNI occurs frequently in patients with gastric cancer, and the incidence of PNI increases with the staging of the tumor. The presence of PNI can provide additional information in predicting the survival outcome for those with stage III tumors.http://dx.doi.org/10.1155/2021/8870562 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kun Yang Yu-Qing Dan Yoon Young Choi Zong-Guang Zhou Woo Jin Hyung Jian-Kun Hu Sung Hoon Noh |
spellingShingle |
Kun Yang Yu-Qing Dan Yoon Young Choi Zong-Guang Zhou Woo Jin Hyung Jian-Kun Hu Sung Hoon Noh The Impact of Nerve Involvement on the Prognosis of Gastric Cancer Patients with Curative Gastrectomy: An International Multicenter Analysis Disease Markers |
author_facet |
Kun Yang Yu-Qing Dan Yoon Young Choi Zong-Guang Zhou Woo Jin Hyung Jian-Kun Hu Sung Hoon Noh |
author_sort |
Kun Yang |
title |
The Impact of Nerve Involvement on the Prognosis of Gastric Cancer Patients with Curative Gastrectomy: An International Multicenter Analysis |
title_short |
The Impact of Nerve Involvement on the Prognosis of Gastric Cancer Patients with Curative Gastrectomy: An International Multicenter Analysis |
title_full |
The Impact of Nerve Involvement on the Prognosis of Gastric Cancer Patients with Curative Gastrectomy: An International Multicenter Analysis |
title_fullStr |
The Impact of Nerve Involvement on the Prognosis of Gastric Cancer Patients with Curative Gastrectomy: An International Multicenter Analysis |
title_full_unstemmed |
The Impact of Nerve Involvement on the Prognosis of Gastric Cancer Patients with Curative Gastrectomy: An International Multicenter Analysis |
title_sort |
impact of nerve involvement on the prognosis of gastric cancer patients with curative gastrectomy: an international multicenter analysis |
publisher |
Hindawi Limited |
series |
Disease Markers |
issn |
1875-8630 |
publishDate |
2021-01-01 |
description |
Background. Several studies have been conducted to investigate the association between the presence of perineural invasion (PNI) and overall survival (OS) of gastric cancer (GC) patients who underwent curative resection, but no consensus has been reached. This study is aimed at determining the prognostic significance of PNI in gastric cancer. Study Design. The data of 2969 patients with gastric cancer and who had undergone curative gastrectomy from 2006 to 2010 in two high-volume hospitals of China and Korea were retrospectively analyzed. PNI positivity was identified when carcinoma cells were found to infiltrate into the perineurium or neural fascicles. The relationships between PNI and other clinicopathological factors were evaluated, and survival analyses were performed. Results. The presence of PNI was detected in 1055 of the 2969 patients (35.5%). Nationality, age, tumor location, size of tumor, differentiation of the tumor, pT stage, pN stage, lymphatic invasion, and vascular invasion had been associated with PNI positivity. The mean survival time of patients with and without PNI was 62.5 months and 87.3 months, respectively (P<0.001). However, the presence of PNI was not an independent prognostic factor for gastric cancer, except for patients in stage III (P=0.037, hazard ratio: 1.21, 95% confidence interval: 1.01-1.44). Conclusion. PNI occurs frequently in patients with gastric cancer, and the incidence of PNI increases with the staging of the tumor. The presence of PNI can provide additional information in predicting the survival outcome for those with stage III tumors. |
url |
http://dx.doi.org/10.1155/2021/8870562 |
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