HCN2 Channel-Induced Rescue of Brain Teratogenesis via Local and Long-Range Bioelectric Repair
Embryonic exposure to the teratogen nicotine results in brain defects, by disrupting endogenous spatial pre patterns necessary for normal brain size and patterning. Extending prior work in Xenopus laevis that showed that misexpression of ion channels can rescue morphogenesis, we demonstrate and char...
Main Authors: | Vaibhav P. Pai, Javier Cervera, Salvador Mafe, Valerie Willocq, Emma K. Lederer, Michael Levin |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2020-05-01
|
Series: | Frontiers in Cellular Neuroscience |
Subjects: | |
Online Access: | https://www.frontiersin.org/article/10.3389/fncel.2020.00136/full |
Similar Items
-
Ion Channel Contributions to Morphological Development: Insights From the Role of Kir2.1 in Bone Development
by: Yunus H. Ozekin, et al.
Published: (2020-06-01) -
Mechanisms of teratogenesis
by: Jenkinson, Peter Colin
Published: (1987) -
Pharmacological safety during pregnancy: the principles of teratogenesis and teratogenicity of drugs
by: O. V. Reshet’ko, et al.
Published: (2016-06-01) -
The Computational Boundary of a “Self”: Developmental Bioelectricity Drives Multicellularity and Scale-Free Cognition
by: Michael Levin, et al.
Published: (2019-12-01) -
HCN4 ion channel function is required for early events that regulate anatomical left-right patterning in a nodal and lefty asymmetric gene expression-independent manner
by: Vaibhav P. Pai, et al.
Published: (2017-10-01)