Development of a quantitative methylation-specific polymerase chain reaction method for monitoring beta cell death in type 1 diabetes.
DNA methylation is a mechanism by which cells control gene expression, and cell-specific genes often exhibit unique patterns of DNA methylation. We previously reported that the mouse insulin-2 gene (Ins2) promoter has three potential methylation (CpG) sites, all of which are unmethylated in insulin-...
Main Authors: | Mohamed I Husseiny, Akio Kuroda, Alexander N Kaye, Indu Nair, Fouad Kandeel, Kevin Ferreri |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2012-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3483298?pdf=render |
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