Weight-Based Adaptation of TNF-Antagonist Induction versus Maintenance Dose
Biologics are highly specific and exhibit few problems in regard to overdosages. In clinical practice, induction schemes with an initial loading dose and a subsequent lower maintenance dose have been established and are of higher efficacy for psoriasis than starting directly with the maintenance dos...
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2011-06-01
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doaj-5876fb92865440c5891bec132f040a072020-11-25T00:28:10ZengKarger PublishersCase Reports in Dermatology1662-65672011-06-013212412910.1159/000329343329343Weight-Based Adaptation of TNF-Antagonist Induction versus Maintenance DoseMarco A. MusterAntonios G.A. KoliosPhilipp FritscheMartin GlatzLars E. FrenchRalph M. TrüebBiologics are highly specific and exhibit few problems in regard to overdosages. In clinical practice, induction schemes with an initial loading dose and a subsequent lower maintenance dose have been established and are of higher efficacy for psoriasis than starting directly with the maintenance dose. As obese patients sometimes respond less well to standard dosages, increases of the maintenance dose, but not the loading doses, have been tried with variable success. In our study, we increased the loading (160 mg instead of 80 mg) but not the maintenance dose of adalimumab in an obese patient with severe psoriasis resistant to previous biologics and methotrexate. Within 12 weeks, both PASI (11 to 1.6) and DLQI (22/30 to 5/30) decreased. This strategy might be an effective and less costly alternative to doubling the maintenance doses, and could be further evaluated for psoriasis patients refractory to previous treatments.http://www.karger.com/Article/FullText/329343TNF-alphaAdalimumabPsoriasis vulgarisObesityPharmacology |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Marco A. Muster Antonios G.A. Kolios Philipp Fritsche Martin Glatz Lars E. French Ralph M. Trüeb |
spellingShingle |
Marco A. Muster Antonios G.A. Kolios Philipp Fritsche Martin Glatz Lars E. French Ralph M. Trüeb Weight-Based Adaptation of TNF-Antagonist Induction versus Maintenance Dose Case Reports in Dermatology TNF-alpha Adalimumab Psoriasis vulgaris Obesity Pharmacology |
author_facet |
Marco A. Muster Antonios G.A. Kolios Philipp Fritsche Martin Glatz Lars E. French Ralph M. Trüeb |
author_sort |
Marco A. Muster |
title |
Weight-Based Adaptation of TNF-Antagonist Induction versus Maintenance Dose |
title_short |
Weight-Based Adaptation of TNF-Antagonist Induction versus Maintenance Dose |
title_full |
Weight-Based Adaptation of TNF-Antagonist Induction versus Maintenance Dose |
title_fullStr |
Weight-Based Adaptation of TNF-Antagonist Induction versus Maintenance Dose |
title_full_unstemmed |
Weight-Based Adaptation of TNF-Antagonist Induction versus Maintenance Dose |
title_sort |
weight-based adaptation of tnf-antagonist induction versus maintenance dose |
publisher |
Karger Publishers |
series |
Case Reports in Dermatology |
issn |
1662-6567 |
publishDate |
2011-06-01 |
description |
Biologics are highly specific and exhibit few problems in regard to overdosages. In clinical practice, induction schemes with an initial loading dose and a subsequent lower maintenance dose have been established and are of higher efficacy for psoriasis than starting directly with the maintenance dose. As obese patients sometimes respond less well to standard dosages, increases of the maintenance dose, but not the loading doses, have been tried with variable success. In our study, we increased the loading (160 mg instead of 80 mg) but not the maintenance dose of adalimumab in an obese patient with severe psoriasis resistant to previous biologics and methotrexate. Within 12 weeks, both PASI (11 to 1.6) and DLQI (22/30 to 5/30) decreased. This strategy might be an effective and less costly alternative to doubling the maintenance doses, and could be further evaluated for psoriasis patients refractory to previous treatments. |
topic |
TNF-alpha Adalimumab Psoriasis vulgaris Obesity Pharmacology |
url |
http://www.karger.com/Article/FullText/329343 |
work_keys_str_mv |
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