Effects of Oral Vitamin C Supplementation on Liver Health and Associated Parameters in Patients With Non-Alcoholic Fatty Liver Disease: A Randomized Clinical Trial
Non-alcoholic fatty liver disease (NAFLD) is now recognized as the most prevalent hepatic disorder worldwide, and an unhealthy lifestyle is the leading risk factor for its occurrence. Vitamin C (VC) has been suggested to protect NAFLD, whereas evidence from randomized controlled trials (RCTs) is spa...
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doaj-587e7359917c466382c6583af2bb0d162021-09-14T04:48:10ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2021-09-01810.3389/fnut.2021.745609745609Effects of Oral Vitamin C Supplementation on Liver Health and Associated Parameters in Patients With Non-Alcoholic Fatty Liver Disease: A Randomized Clinical TrialZhangya He0Xiaomin Li1Xiaomin Li2Hexiang Yang3Pei Wu4Shanshan Wang5Dan Cao6Xiaoxiao Guo7Zhangrui Xu8Jiayi Gao9Jiayi Gao10Wanyu Zhang11Wanyu Zhang12Xiaoqin Luo13Department of Nutrition and Food Safety of School of Public Health, Xi'an Jiaotong University, Xi'an, ChinaDepartment of Nutrition and Food Safety of School of Public Health, Xi'an Jiaotong University, Xi'an, ChinaDepartment of Clinical Nutrition, Xianyang Central Hospital, Xianyang, ChinaDepartment of Nutrition and Food Safety of School of Public Health, Xi'an Jiaotong University, Xi'an, ChinaDepartment of Nutrition and Food Safety of School of Public Health, Xi'an Jiaotong University, Xi'an, ChinaDepartment of Nutrition and Food Safety of School of Public Health, Xi'an Jiaotong University, Xi'an, ChinaDepartment of Nutrition and Food Safety of School of Public Health, Xi'an Jiaotong University, Xi'an, ChinaDepartment of Nutrition and Food Safety of School of Public Health, Xi'an Jiaotong University, Xi'an, ChinaDepartment of Nutrition and Food Safety of School of Public Health, Xi'an Jiaotong University, Xi'an, ChinaDepartment of Nutrition and Food Safety of School of Public Health, Xi'an Jiaotong University, Xi'an, ChinaEmergency Medical Center, Xi'an Public Health Center, Xi'an, ChinaDepartment of Nutrition and Food Safety of School of Public Health, Xi'an Jiaotong University, Xi'an, ChinaDepartment of Shaanxi Health Supervision Center, Xi'an, ChinaDepartment of Nutrition and Food Safety of School of Public Health, Xi'an Jiaotong University, Xi'an, ChinaNon-alcoholic fatty liver disease (NAFLD) is now recognized as the most prevalent hepatic disorder worldwide, and an unhealthy lifestyle is the leading risk factor for its occurrence. Vitamin C (VC) has been suggested to protect NAFLD, whereas evidence from randomized controlled trials (RCTs) is sparse. In this study, we aimed to investigate the potential benefits of VC supplementation daily on liver health and associated parameters in patients with NAFLD. In this double-blind, RCT, 84 patients with NAFLD, aged 18–60 years old, were assigned to 12 weeks of oral treatment with either low (250 mg/day, n = 26), medium (1,000 mg/day, n = 30), or high (2,000 mg/day, n = 28) doses of VC supplements. After the intervention, the Medium group had a more significant decrease in aspartate aminotransferase [Medium, −5.00 (−10.25, −1.75) vs. High, −2.50 (−7.75, 0.00), P = 0.02] and alanine aminotransferase [Medium, −8.00 (−18.00, −1.75) vs. High, −3.50 (−13.75, 4.25), P = 0.05; Medium vs. Low, −3.00 (−9.00, 5.50), P = 0.031]. The levels of other indicators of liver health, such as gamma-glutamyl transferase, alkaline phosphatase, total bilirubin, and direct bilirubin were decreased after the intervention but comparable among the three groups and so did the parameters of glucose metabolism, such as fasting insulin, fasting glucose, and homeostasis model assessment for insulin resistance. The plasma level of VC in patients and total adiponectin and high molecular weight (HMW) adiponectin levels were also elevated but not in a dose-dependent manner. Meanwhile, analysis of fecal microbiota composition showed an increase in the alpha diversity (Abundance-based Coverage Estimator (ACE), Shannon, chao1, and Simpson) both in the Low and the Medium groups. A total of 12 weeks of VC supplementation, especially 1,000 mg/day, improved liver health and glucose metabolism in patients with NAFLD. The elevated plasma levels of VC, total and HMW adiponectin, and the improvement of intestinal microbiota may have made some contributions.https://www.frontiersin.org/articles/10.3389/fnut.2021.745609/fullvitamin CNAFLDglucose metabolismadiponectinmicrobiota |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Zhangya He Xiaomin Li Xiaomin Li Hexiang Yang Pei Wu Shanshan Wang Dan Cao Xiaoxiao Guo Zhangrui Xu Jiayi Gao Jiayi Gao Wanyu Zhang Wanyu Zhang Xiaoqin Luo |
spellingShingle |
Zhangya He Xiaomin Li Xiaomin Li Hexiang Yang Pei Wu Shanshan Wang Dan Cao Xiaoxiao Guo Zhangrui Xu Jiayi Gao Jiayi Gao Wanyu Zhang Wanyu Zhang Xiaoqin Luo Effects of Oral Vitamin C Supplementation on Liver Health and Associated Parameters in Patients With Non-Alcoholic Fatty Liver Disease: A Randomized Clinical Trial Frontiers in Nutrition vitamin C NAFLD glucose metabolism adiponectin microbiota |
author_facet |
Zhangya He Xiaomin Li Xiaomin Li Hexiang Yang Pei Wu Shanshan Wang Dan Cao Xiaoxiao Guo Zhangrui Xu Jiayi Gao Jiayi Gao Wanyu Zhang Wanyu Zhang Xiaoqin Luo |
author_sort |
Zhangya He |
title |
Effects of Oral Vitamin C Supplementation on Liver Health and Associated Parameters in Patients With Non-Alcoholic Fatty Liver Disease: A Randomized Clinical Trial |
title_short |
Effects of Oral Vitamin C Supplementation on Liver Health and Associated Parameters in Patients With Non-Alcoholic Fatty Liver Disease: A Randomized Clinical Trial |
title_full |
Effects of Oral Vitamin C Supplementation on Liver Health and Associated Parameters in Patients With Non-Alcoholic Fatty Liver Disease: A Randomized Clinical Trial |
title_fullStr |
Effects of Oral Vitamin C Supplementation on Liver Health and Associated Parameters in Patients With Non-Alcoholic Fatty Liver Disease: A Randomized Clinical Trial |
title_full_unstemmed |
Effects of Oral Vitamin C Supplementation on Liver Health and Associated Parameters in Patients With Non-Alcoholic Fatty Liver Disease: A Randomized Clinical Trial |
title_sort |
effects of oral vitamin c supplementation on liver health and associated parameters in patients with non-alcoholic fatty liver disease: a randomized clinical trial |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Nutrition |
issn |
2296-861X |
publishDate |
2021-09-01 |
description |
Non-alcoholic fatty liver disease (NAFLD) is now recognized as the most prevalent hepatic disorder worldwide, and an unhealthy lifestyle is the leading risk factor for its occurrence. Vitamin C (VC) has been suggested to protect NAFLD, whereas evidence from randomized controlled trials (RCTs) is sparse. In this study, we aimed to investigate the potential benefits of VC supplementation daily on liver health and associated parameters in patients with NAFLD. In this double-blind, RCT, 84 patients with NAFLD, aged 18–60 years old, were assigned to 12 weeks of oral treatment with either low (250 mg/day, n = 26), medium (1,000 mg/day, n = 30), or high (2,000 mg/day, n = 28) doses of VC supplements. After the intervention, the Medium group had a more significant decrease in aspartate aminotransferase [Medium, −5.00 (−10.25, −1.75) vs. High, −2.50 (−7.75, 0.00), P = 0.02] and alanine aminotransferase [Medium, −8.00 (−18.00, −1.75) vs. High, −3.50 (−13.75, 4.25), P = 0.05; Medium vs. Low, −3.00 (−9.00, 5.50), P = 0.031]. The levels of other indicators of liver health, such as gamma-glutamyl transferase, alkaline phosphatase, total bilirubin, and direct bilirubin were decreased after the intervention but comparable among the three groups and so did the parameters of glucose metabolism, such as fasting insulin, fasting glucose, and homeostasis model assessment for insulin resistance. The plasma level of VC in patients and total adiponectin and high molecular weight (HMW) adiponectin levels were also elevated but not in a dose-dependent manner. Meanwhile, analysis of fecal microbiota composition showed an increase in the alpha diversity (Abundance-based Coverage Estimator (ACE), Shannon, chao1, and Simpson) both in the Low and the Medium groups. A total of 12 weeks of VC supplementation, especially 1,000 mg/day, improved liver health and glucose metabolism in patients with NAFLD. The elevated plasma levels of VC, total and HMW adiponectin, and the improvement of intestinal microbiota may have made some contributions. |
topic |
vitamin C NAFLD glucose metabolism adiponectin microbiota |
url |
https://www.frontiersin.org/articles/10.3389/fnut.2021.745609/full |
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