α-proteobacteria synthesize biotin precursor pimeloyl-ACP using BioZ 3-ketoacyl-ACP synthase and lysine catabolism

α-proteobacteria synthesize biotin precursor pimeloyl-ACP using BioZ 3-ketoacyl-ACP synthase and lysine catabolism

Biosynthesis of biotin precursor, pimelate moiety, is elucidated in Escherichia coli and Bacillus subtilis, but not understood in alphaproteobacteria. Here, the authors show that BioZ, a 3-ketoacyl-ACP synthase, catalayses pimeloyl-thioester synthesis in alphaproteobacteria using malonyl-ACP and glu...

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Bibliographic Details
Main Authors: Yuanyuan Hu, John E. Cronan
Format: Article
Language:English
Published: Nature Publishing Group 2020-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-19251-5
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spelling doaj-588f2278d1304119828bd44f2df713d12021-05-11T08:19:43ZengNature Publishing GroupNature Communications2041-17232020-11-0111111310.1038/s41467-020-19251-5α-proteobacteria synthesize biotin precursor pimeloyl-ACP using BioZ 3-ketoacyl-ACP synthase and lysine catabolismYuanyuan Hu0John E. Cronan1Department of Biochemistry, University of Illinois at Urbana-ChampaignDepartment of Microbiology, University of Illinois at Urbana-ChampaignBiosynthesis of biotin precursor, pimelate moiety, is elucidated in Escherichia coli and Bacillus subtilis, but not understood in alphaproteobacteria. Here, the authors show that BioZ, a 3-ketoacyl-ACP synthase, catalayses pimeloyl-thioester synthesis in alphaproteobacteria using malonyl-ACP and glutaryl-CoA that is derived from lysine degradation.https://doi.org/10.1038/s41467-020-19251-5
collection DOAJ
language English
format Article
sources DOAJ
author Yuanyuan Hu
John E. Cronan
spellingShingle Yuanyuan Hu
John E. Cronan
α-proteobacteria synthesize biotin precursor pimeloyl-ACP using BioZ 3-ketoacyl-ACP synthase and lysine catabolism
Nature Communications
author_facet Yuanyuan Hu
John E. Cronan
author_sort Yuanyuan Hu
title α-proteobacteria synthesize biotin precursor pimeloyl-ACP using BioZ 3-ketoacyl-ACP synthase and lysine catabolism
title_short α-proteobacteria synthesize biotin precursor pimeloyl-ACP using BioZ 3-ketoacyl-ACP synthase and lysine catabolism
title_full α-proteobacteria synthesize biotin precursor pimeloyl-ACP using BioZ 3-ketoacyl-ACP synthase and lysine catabolism
title_fullStr α-proteobacteria synthesize biotin precursor pimeloyl-ACP using BioZ 3-ketoacyl-ACP synthase and lysine catabolism
title_full_unstemmed α-proteobacteria synthesize biotin precursor pimeloyl-ACP using BioZ 3-ketoacyl-ACP synthase and lysine catabolism
title_sort α-proteobacteria synthesize biotin precursor pimeloyl-acp using bioz 3-ketoacyl-acp synthase and lysine catabolism
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2020-11-01
description Biosynthesis of biotin precursor, pimelate moiety, is elucidated in Escherichia coli and Bacillus subtilis, but not understood in alphaproteobacteria. Here, the authors show that BioZ, a 3-ketoacyl-ACP synthase, catalayses pimeloyl-thioester synthesis in alphaproteobacteria using malonyl-ACP and glutaryl-CoA that is derived from lysine degradation.
url https://doi.org/10.1038/s41467-020-19251-5
work_keys_str_mv AT yuanyuanhu aproteobacteriasynthesizebiotinprecursorpimeloylacpusingbioz3ketoacylacpsynthaseandlysinecatabolism
AT johnecronan aproteobacteriasynthesizebiotinprecursorpimeloylacpusingbioz3ketoacylacpsynthaseandlysinecatabolism
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