Computational Modeling of Inhibitory Transsynaptic Signaling in Hippocampal and Cortical Neurons Expressing Intrabodies Against Gephyrin

Computational Modeling of Inhibitory Transsynaptic Signaling in Hippocampal and Cortical Neurons Expressing Intrabodies Against Gephyrin

GABAergic transmission regulates neuronal excitability, dendritic integration of synaptic signals and oscillatory activity, thought to be involved in high cognitive functions. By anchoring synaptic receptors just opposite to release sites, the scaffold protein gephyrin plays a key role in these task...

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Bibliographic Details
Main Authors: Carmen A. Lupascu, Annunziato Morabito, Federica Ruggeri, Chiara Parisi, Domenico Pimpinella, Rocco Pizzarelli, Giovanni Meli, Silvia Marinelli, Enrico Cherubini, Antonino Cattaneo, Michele Migliore
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Cellular Neuroscience
Subjects:
gephyrin
intrabodies
computational model
hippocampus
transsynaptic signaling
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2020.00173/full

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https://www.frontiersin.org/article/10.3389/fncel.2020.00173/full

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