Regular Music Exposure in Juvenile Rats Facilitates Conditioned Fear Extinction and Reduces Anxiety after Foot Shock in Adulthood

Regular Music Exposure in Juvenile Rats Facilitates Conditioned Fear Extinction and Reduces Anxiety after Foot Shock in Adulthood

Music exposure is known to play a positive role in learning and memory and can be a complementary treatment for anxiety and fear. However, whether juvenile music exposure affects adult behavior is not known. Two-week-old Sprague-Dawley rats were exposed to music for 2 hours daily or to background no...

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Main Authors: Si Chen, Tuo Liang, Fiona H. Zhou, Ye Cao, Chao Wang, Fei-Yifan Wang, Fang Li, Xin-Fu Zhou, Jian-Yi Zhang, Chang-Qi Li
Format: Article
Language:English
Published: Hindawi Limited 2019-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2019/8740674
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spelling doaj-58906e3a7acf4be1b8daa1e98eaabd772020-11-25T02:03:07ZengHindawi LimitedBioMed Research International2314-61332314-61412019-01-01201910.1155/2019/87406748740674Regular Music Exposure in Juvenile Rats Facilitates Conditioned Fear Extinction and Reduces Anxiety after Foot Shock in AdulthoodSi Chen0Tuo Liang1Fiona H. Zhou2Ye Cao3Chao Wang4Fei-Yifan Wang5Fang Li6Xin-Fu Zhou7Jian-Yi Zhang8Chang-Qi Li9Department of Neurology, Xiangya Hospital, Central South University, Xiangya Road 88, Changsha, Hunan 410008, ChinaDepartment of Anatomy and Neurobiology, Xiangya School of Medicine, Central South University, Tongzipo Road 172, Changsha, Hunan 410013, ChinaSansom Institute, School of Pharmacology and Medical Sciences, University of South Australia, Adelaide 5001, AustraliaSchool of Biological Science and Technology, Central South University, Tongzipo Road 172, Changsha, Hunan 410013, ChinaSchool of Biological Science and Technology, Central South University, Tongzipo Road 172, Changsha, Hunan 410013, ChinaXiang-Ya College of Medicine, Central South University, Tongzipo Road 172, Changsha, Hunan, ChinaDepartment of Anatomy and Neurobiology, Xiangya School of Medicine, Central South University, Tongzipo Road 172, Changsha, Hunan 410013, ChinaSansom Institute, School of Pharmacology and Medical Sciences, University of South Australia, Adelaide 5001, AustraliaDepartment of Anatomy and Neurobiology, Xiangya School of Medicine, Central South University, Tongzipo Road 172, Changsha, Hunan 410013, ChinaDepartment of Anatomy and Neurobiology, Xiangya School of Medicine, Central South University, Tongzipo Road 172, Changsha, Hunan 410013, ChinaMusic exposure is known to play a positive role in learning and memory and can be a complementary treatment for anxiety and fear. However, whether juvenile music exposure affects adult behavior is not known. Two-week-old Sprague-Dawley rats were exposed to music for 2 hours daily or to background noise (controls) for a period of 3 weeks. At 60 days of age, rats were subjected to auditory fear conditioning, fear extinction training, and anxiety-like behavior assessments or to anterior cingulate cortex (ACC) brain-derived neurotrophic factor (BDNF) assays. We found that the music-exposed rats showed significantly less freezing behaviors during fear extinction training and spent more time in the open arm of the elevated plus maze after fear conditioning when compared with the control rats. Moreover, the BDNF levels in the ACC in the music group were significantly higher than those of the controls with the fear conditioning session. This result suggests that music exposure in juvenile rats decreases anxiety-like behaviors, facilitates fear extinction, and increases BDNF levels in the ACC in adulthood after a stressful event.http://dx.doi.org/10.1155/2019/8740674
collection DOAJ
language English
format Article
sources DOAJ
author Si Chen
Tuo Liang
Fiona H. Zhou
Ye Cao
Chao Wang
Fei-Yifan Wang
Fang Li
Xin-Fu Zhou
Jian-Yi Zhang
Chang-Qi Li
spellingShingle Si Chen
Tuo Liang
Fiona H. Zhou
Ye Cao
Chao Wang
Fei-Yifan Wang
Fang Li
Xin-Fu Zhou
Jian-Yi Zhang
Chang-Qi Li
Regular Music Exposure in Juvenile Rats Facilitates Conditioned Fear Extinction and Reduces Anxiety after Foot Shock in Adulthood
BioMed Research International
author_facet Si Chen
Tuo Liang
Fiona H. Zhou
Ye Cao
Chao Wang
Fei-Yifan Wang
Fang Li
Xin-Fu Zhou
Jian-Yi Zhang
Chang-Qi Li
author_sort Si Chen
title Regular Music Exposure in Juvenile Rats Facilitates Conditioned Fear Extinction and Reduces Anxiety after Foot Shock in Adulthood
title_short Regular Music Exposure in Juvenile Rats Facilitates Conditioned Fear Extinction and Reduces Anxiety after Foot Shock in Adulthood
title_full Regular Music Exposure in Juvenile Rats Facilitates Conditioned Fear Extinction and Reduces Anxiety after Foot Shock in Adulthood
title_fullStr Regular Music Exposure in Juvenile Rats Facilitates Conditioned Fear Extinction and Reduces Anxiety after Foot Shock in Adulthood
title_full_unstemmed Regular Music Exposure in Juvenile Rats Facilitates Conditioned Fear Extinction and Reduces Anxiety after Foot Shock in Adulthood
title_sort regular music exposure in juvenile rats facilitates conditioned fear extinction and reduces anxiety after foot shock in adulthood
publisher Hindawi Limited
series BioMed Research International
issn 2314-6133
2314-6141
publishDate 2019-01-01
description Music exposure is known to play a positive role in learning and memory and can be a complementary treatment for anxiety and fear. However, whether juvenile music exposure affects adult behavior is not known. Two-week-old Sprague-Dawley rats were exposed to music for 2 hours daily or to background noise (controls) for a period of 3 weeks. At 60 days of age, rats were subjected to auditory fear conditioning, fear extinction training, and anxiety-like behavior assessments or to anterior cingulate cortex (ACC) brain-derived neurotrophic factor (BDNF) assays. We found that the music-exposed rats showed significantly less freezing behaviors during fear extinction training and spent more time in the open arm of the elevated plus maze after fear conditioning when compared with the control rats. Moreover, the BDNF levels in the ACC in the music group were significantly higher than those of the controls with the fear conditioning session. This result suggests that music exposure in juvenile rats decreases anxiety-like behaviors, facilitates fear extinction, and increases BDNF levels in the ACC in adulthood after a stressful event.
url http://dx.doi.org/10.1155/2019/8740674
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