Fenofibrate Nanocrystals Embedded in Oral Strip-Films for Bioavailability Enhancement
The aim of the present study was to make a fenofibrate (FNB) nanocrystal (NC) by wet media milling, characterizations and formulates into oral strip-films (OSFs). Mechanical properties, redispersion study, and solid-state characterizations results suggested that reduction of drug crystal size at nan...
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doaj-58938b119f07438c9f76d4a32e843a212020-11-24T21:17:52ZengMDPI AGBioengineering2306-53542018-02-01511610.3390/bioengineering5010016bioengineering5010016Fenofibrate Nanocrystals Embedded in Oral Strip-Films for Bioavailability EnhancementBhavesh D. Kevadiya0Manish Barvaliya1Lu Zhang2Ashish Anovadiya3Harshad Brahmbhatt4Parimal Paul5Chandrabhanu Tripathi6Department of Chemical, Biological and Pharmaceutical Engineering, New Jersey Institute of Technology, Newark, NJ 07102, USADepartment of Pharmacology, Government Medical College, Bhavnagar 364002, Gujarat, IndiaDepartment of Chemical, Biological and Pharmaceutical Engineering, New Jersey Institute of Technology, Newark, NJ 07102, USADepartment of Pharmacology, Government Medical College, Bhavnagar 364002, Gujarat, IndiaAnalytical Discipline and Centralized Instrument Facility, The Academy of Scientific & Innovative Research (AcSIR), Central Salt and Marine Chemicals Research Institute, Council of Scientific and Industrial Research (CSIR), G.B. Marg, Bhavnagar 364002, Gujarat, IndiaAnalytical Discipline and Centralized Instrument Facility, The Academy of Scientific & Innovative Research (AcSIR), Central Salt and Marine Chemicals Research Institute, Council of Scientific and Industrial Research (CSIR), G.B. Marg, Bhavnagar 364002, Gujarat, IndiaDepartment of Pharmacology, Government Medical College, Bhavnagar 364002, Gujarat, IndiaThe aim of the present study was to make a fenofibrate (FNB) nanocrystal (NC) by wet media milling, characterizations and formulates into oral strip-films (OSFs). Mechanical properties, redispersion study, and solid-state characterizations results suggested that reduction of drug crystal size at nanoscale and incorporation into OSFs does not affect the solid-state properties of the drug. In vitro dissolution kinetics showed enhanced dissolution rate was easily manipulated by changing the thickness of the OSF. In situ UV-imaging was used to monitor drug dissolution qualitatively and quantitatively in real time. Results confirm that the intrinsic dissolution rates and surface drug concentration measured with this device were in agreement with the USP-IV dissolution profiles. In vivo pharmacokinetics in rabbits showed a significant difference in the pharmacokinetics parameter (1.4 fold increase bioavailability) of FNB NC-loaded OSFs as compared to the marketed formulation “Tricor” and as-received (pristine) drug. This approach of drug nanocrystallization and incorporation into OSFs may have significant applications in cost-effective tools for bioavailability enhancement of FNB.http://www.mdpi.com/2306-5354/5/1/16bioavailabilityfenofibratemedia millingpharmacokineticsUV imaging |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Bhavesh D. Kevadiya Manish Barvaliya Lu Zhang Ashish Anovadiya Harshad Brahmbhatt Parimal Paul Chandrabhanu Tripathi |
spellingShingle |
Bhavesh D. Kevadiya Manish Barvaliya Lu Zhang Ashish Anovadiya Harshad Brahmbhatt Parimal Paul Chandrabhanu Tripathi Fenofibrate Nanocrystals Embedded in Oral Strip-Films for Bioavailability Enhancement Bioengineering bioavailability fenofibrate media milling pharmacokinetics UV imaging |
author_facet |
Bhavesh D. Kevadiya Manish Barvaliya Lu Zhang Ashish Anovadiya Harshad Brahmbhatt Parimal Paul Chandrabhanu Tripathi |
author_sort |
Bhavesh D. Kevadiya |
title |
Fenofibrate Nanocrystals Embedded in Oral Strip-Films for Bioavailability Enhancement |
title_short |
Fenofibrate Nanocrystals Embedded in Oral Strip-Films for Bioavailability Enhancement |
title_full |
Fenofibrate Nanocrystals Embedded in Oral Strip-Films for Bioavailability Enhancement |
title_fullStr |
Fenofibrate Nanocrystals Embedded in Oral Strip-Films for Bioavailability Enhancement |
title_full_unstemmed |
Fenofibrate Nanocrystals Embedded in Oral Strip-Films for Bioavailability Enhancement |
title_sort |
fenofibrate nanocrystals embedded in oral strip-films for bioavailability enhancement |
publisher |
MDPI AG |
series |
Bioengineering |
issn |
2306-5354 |
publishDate |
2018-02-01 |
description |
The aim of the present study was to make a fenofibrate (FNB) nanocrystal (NC) by wet media milling, characterizations and formulates into oral strip-films (OSFs). Mechanical properties, redispersion study, and solid-state characterizations results suggested that reduction of drug crystal size at nanoscale and incorporation into OSFs does not affect the solid-state properties of the drug. In vitro dissolution kinetics showed enhanced dissolution rate was easily manipulated by changing the thickness of the OSF. In situ UV-imaging was used to monitor drug dissolution qualitatively and quantitatively in real time. Results confirm that the intrinsic dissolution rates and surface drug concentration measured with this device were in agreement with the USP-IV dissolution profiles. In vivo pharmacokinetics in rabbits showed a significant difference in the pharmacokinetics parameter (1.4 fold increase bioavailability) of FNB NC-loaded OSFs as compared to the marketed formulation “Tricor” and as-received (pristine) drug. This approach of drug nanocrystallization and incorporation into OSFs may have significant applications in cost-effective tools for bioavailability enhancement of FNB. |
topic |
bioavailability fenofibrate media milling pharmacokinetics UV imaging |
url |
http://www.mdpi.com/2306-5354/5/1/16 |
work_keys_str_mv |
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