The tyrosine kinase Btk regulates the macrophage response to Listeria monocytogenes infection.

The tyrosine kinase Btk regulates the macrophage response to Listeria monocytogenes infection.

In this study we investigated the role of Bruton's tyrosine kinase (Btk) in the immune response to the Gram-positive intracellular bacterium Listeria monocytogenes (Lm). In response to Lm infection, Btk was activated in bone marrow-derived macrophages (BMMs) and Btk (-/-) BMMs showed enhanced T...

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Main Authors: Afitap Derya Köprülü, Renate Kastner, Sebastian Wienerroither, Caroline Lassnig, Eva Maria Putz, Olivia Majer, Benjamin Reutterer, Veronika Sexl, Karl Kuchler, Mathias Müller, Thomas Decker, Wilfried Ellmeier
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3609758?pdf=render

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