Long-term outcomes of renal denervation and related sex characteristics: data from a three-year follow-up
Aim. To study the long-term outcomes of renal denervation (RDN) within 3-year follow-up with an assessment of blood pressure (BP) changes, the severity of target organ damage and the levels of pro- and anti-inflammatory cytokines in patients with resistant hypertension (RH), taking into account sex...
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«FIRMA «SILICEA» LLC
2021-05-01
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doaj-5894cbb58af544ffa84b46e0b1c69da02021-07-28T14:02:41Zrus«FIRMA «SILICEA» LLC Российский кардиологический журнал1560-40712618-76202021-05-0126410.15829/1560-4071-2021-40063083Long-term outcomes of renal denervation and related sex characteristics: data from a three-year follow-upI. V. Zyubanova0V. F. Mordovin1A. Yu. Falkovskaya2S. E. Pekarsky3T. M. Ripp4M. A. Manukyan5V. A. Lichikaki6A. M. Gusakova7T. R. Ryabova8A. E. Baev9Cardiology Research Institute, Tomsk National Research Medical CenterCardiology Research Institute, Tomsk National Research Medical CenterCardiology Research Institute, Tomsk National Research Medical CenterCardiology Research Institute, Tomsk National Research Medical CenterCardiology Research Institute, Tomsk National Research Medical CenterCardiology Research Institute, Tomsk National Research Medical CenterCardiology Research Institute, Tomsk National Research Medical CenterCardiology Research Institute, Tomsk National Research Medical CenterCardiology Research Institute, Tomsk National Research Medical CenterCardiology Research Institute, Tomsk National Research Medical CenterAim. To study the long-term outcomes of renal denervation (RDN) within 3-year follow-up with an assessment of blood pressure (BP) changes, the severity of target organ damage and the levels of pro- and anti-inflammatory cytokines in patients with resistant hypertension (RH), taking into account sex characteristics.Material and methods. A total of 42 patients with RH were examined at baseline, 1, 2, and 3 years after RDN on the background of antihypertensive therapy. Twenty-four-hour BP monitoring, echocardiography, assessment of creatinine level and estimated glomerular filtration rate (eGFR), as well as determination of some cytokines (interleukin (IL)-1β, 6, 10, tumor necrosis factor-α) were performed.Results. There was a persistent BP decrease in men and women for three years compared with the initial level by an average of 17 [4; 31]/10 [0; 18] mm Hg (p<0,05). Decrease in BP variability from 17,9±5,1 to 15,2±3,6 mm Hg was observed mainly by means of women, while the decrease in left ventricular mass from 250,4±64,0 to 229,3±61,9 g was mainly by means of men. Creatinine level was unchanged, while eGFR decreased from 78,8±16,1 to 74,5±20,3 ml/ min/1,73 m2 over 3 years; the mean eGFR decline was 1,4 ml/min/1,73 m2 in year. All studied cytokines tended to decrease regardless of sex: tumor necrosis factor-α — from 2,1 [1,2; 77] to 2,1 [1,7; 2,6] pg/ml (p=0,022); IL-1β — from 2,2 [1,5; 2,4] to 1,6 [1,1; 1,5] pg/ml (p=0,034); IL-6 — from 3,8 [1,6; 4,9] to 2,8 [1,8; 3,0] pg/ml (p>0,05), IL-10 — from 5,8 [3,2; 8,2] to 2,8 [2,6; 2,9] pg/ml (p=0,000), correlating with IL-6 dynamics.Conclusion. Three years after RDN, there is a persistent decrease in mean 24-hour BP, regardless of sex. In women, a more pronounced BP variability decrease is observed, while in men — regression of left ventricular mass. There is no significant decrease in eGFR in the long-term period. The decrease in proinflammatory cytokines maintains, and in some cases becomes more pronounced within three years after RDN.https://russjcardiol.elpub.ru/jour/article/view/4006resistant hypertensionrenal denervationorgan protectionproin-flammatory cytokines |
collection |
DOAJ |
language |
Russian |
format |
Article |
sources |
DOAJ |
author |
I. V. Zyubanova V. F. Mordovin A. Yu. Falkovskaya S. E. Pekarsky T. M. Ripp M. A. Manukyan V. A. Lichikaki A. M. Gusakova T. R. Ryabova A. E. Baev |
spellingShingle |
I. V. Zyubanova V. F. Mordovin A. Yu. Falkovskaya S. E. Pekarsky T. M. Ripp M. A. Manukyan V. A. Lichikaki A. M. Gusakova T. R. Ryabova A. E. Baev Long-term outcomes of renal denervation and related sex characteristics: data from a three-year follow-up Российский кардиологический журнал resistant hypertension renal denervation organ protection proin-flammatory cytokines |
author_facet |
I. V. Zyubanova V. F. Mordovin A. Yu. Falkovskaya S. E. Pekarsky T. M. Ripp M. A. Manukyan V. A. Lichikaki A. M. Gusakova T. R. Ryabova A. E. Baev |
author_sort |
I. V. Zyubanova |
title |
Long-term outcomes of renal denervation and related sex characteristics: data from a three-year follow-up |
title_short |
Long-term outcomes of renal denervation and related sex characteristics: data from a three-year follow-up |
title_full |
Long-term outcomes of renal denervation and related sex characteristics: data from a three-year follow-up |
title_fullStr |
Long-term outcomes of renal denervation and related sex characteristics: data from a three-year follow-up |
title_full_unstemmed |
Long-term outcomes of renal denervation and related sex characteristics: data from a three-year follow-up |
title_sort |
long-term outcomes of renal denervation and related sex characteristics: data from a three-year follow-up |
publisher |
«FIRMA «SILICEA» LLC |
series |
Российский кардиологический журнал |
issn |
1560-4071 2618-7620 |
publishDate |
2021-05-01 |
description |
Aim. To study the long-term outcomes of renal denervation (RDN) within 3-year follow-up with an assessment of blood pressure (BP) changes, the severity of target organ damage and the levels of pro- and anti-inflammatory cytokines in patients with resistant hypertension (RH), taking into account sex characteristics.Material and methods. A total of 42 patients with RH were examined at baseline, 1, 2, and 3 years after RDN on the background of antihypertensive therapy. Twenty-four-hour BP monitoring, echocardiography, assessment of creatinine level and estimated glomerular filtration rate (eGFR), as well as determination of some cytokines (interleukin (IL)-1β, 6, 10, tumor necrosis factor-α) were performed.Results. There was a persistent BP decrease in men and women for three years compared with the initial level by an average of 17 [4; 31]/10 [0; 18] mm Hg (p<0,05). Decrease in BP variability from 17,9±5,1 to 15,2±3,6 mm Hg was observed mainly by means of women, while the decrease in left ventricular mass from 250,4±64,0 to 229,3±61,9 g was mainly by means of men. Creatinine level was unchanged, while eGFR decreased from 78,8±16,1 to 74,5±20,3 ml/ min/1,73 m2 over 3 years; the mean eGFR decline was 1,4 ml/min/1,73 m2 in year. All studied cytokines tended to decrease regardless of sex: tumor necrosis factor-α — from 2,1 [1,2; 77] to 2,1 [1,7; 2,6] pg/ml (p=0,022); IL-1β — from 2,2 [1,5; 2,4] to 1,6 [1,1; 1,5] pg/ml (p=0,034); IL-6 — from 3,8 [1,6; 4,9] to 2,8 [1,8; 3,0] pg/ml (p>0,05), IL-10 — from 5,8 [3,2; 8,2] to 2,8 [2,6; 2,9] pg/ml (p=0,000), correlating with IL-6 dynamics.Conclusion. Three years after RDN, there is a persistent decrease in mean 24-hour BP, regardless of sex. In women, a more pronounced BP variability decrease is observed, while in men — regression of left ventricular mass. There is no significant decrease in eGFR in the long-term period. The decrease in proinflammatory cytokines maintains, and in some cases becomes more pronounced within three years after RDN. |
topic |
resistant hypertension renal denervation organ protection proin-flammatory cytokines |
url |
https://russjcardiol.elpub.ru/jour/article/view/4006 |
work_keys_str_mv |
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