A novel and practical asymmetric synthesis of dapoxetine hydrochloride

A novel and practical asymmetric synthesis of dapoxetine hydrochloride by using the chiral auxiliary (S)-tert-butanesulfinamide was explored. The synthesis was concise, mild, and easy to perform. The overall yield and stereoselectivity were excellent.

Bibliographic Details
Main Authors:	Yijun Zhu, Zhenren Liu, Hongyan Li, Deyong Ye, Weicheng Zhou
Format:	Article
Language:	English
Published:	Beilstein-Institut 2015-12-01
Series:	Beilstein Journal of Organic Chemistry
Subjects:	asymmetric synthesis dapoxetine hydrochloride stereoselectivity (S)-tert-butanesulfinamide
Online Access:	https://doi.org/10.3762/bjoc.11.283

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spelling	doaj-589968f897e34e4aa68d80bee6e2c76f2021-02-02T06:59:31ZengBeilstein-InstitutBeilstein Journal of Organic Chemistry1860-53972015-12-011112641264510.3762/bjoc.11.2831860-5397-11-283A novel and practical asymmetric synthesis of dapoxetine hydrochlorideYijun Zhu0Zhenren Liu1Hongyan Li2Deyong Ye3Weicheng Zhou4State Key Lab of New Drug & Pharmaceutical Process, Shanghai Key Lab of Anti-Infectives, State Institute of Pharmaceutical Industry, No. 285, Gebaini Rd., Shanghai 201203, ChinaState Key Lab of New Drug & Pharmaceutical Process, Shanghai Key Lab of Anti-Infectives, State Institute of Pharmaceutical Industry, No. 285, Gebaini Rd., Shanghai 201203, ChinaState Key Lab of New Drug & Pharmaceutical Process, Shanghai Key Lab of Anti-Infectives, State Institute of Pharmaceutical Industry, No. 285, Gebaini Rd., Shanghai 201203, ChinaSchool of Pharmacy, Fudan University, No. 826, Zhangheng Rd., Shanghai 201203, ChinaState Key Lab of New Drug & Pharmaceutical Process, Shanghai Key Lab of Anti-Infectives, State Institute of Pharmaceutical Industry, No. 285, Gebaini Rd., Shanghai 201203, ChinaA novel and practical asymmetric synthesis of dapoxetine hydrochloride by using the chiral auxiliary (S)-tert-butanesulfinamide was explored. The synthesis was concise, mild, and easy to perform. The overall yield and stereoselectivity were excellent.https://doi.org/10.3762/bjoc.11.283asymmetric synthesisdapoxetine hydrochloridestereoselectivity(S)-tert-butanesulfinamide
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Yijun Zhu Zhenren Liu Hongyan Li Deyong Ye Weicheng Zhou
spellingShingle	Yijun Zhu Zhenren Liu Hongyan Li Deyong Ye Weicheng Zhou A novel and practical asymmetric synthesis of dapoxetine hydrochloride Beilstein Journal of Organic Chemistry asymmetric synthesis dapoxetine hydrochloride stereoselectivity (S)-tert-butanesulfinamide
author_facet	Yijun Zhu Zhenren Liu Hongyan Li Deyong Ye Weicheng Zhou
author_sort	Yijun Zhu
title	A novel and practical asymmetric synthesis of dapoxetine hydrochloride
title_short	A novel and practical asymmetric synthesis of dapoxetine hydrochloride
title_full	A novel and practical asymmetric synthesis of dapoxetine hydrochloride
title_fullStr	A novel and practical asymmetric synthesis of dapoxetine hydrochloride
title_full_unstemmed	A novel and practical asymmetric synthesis of dapoxetine hydrochloride
title_sort	novel and practical asymmetric synthesis of dapoxetine hydrochloride
publisher	Beilstein-Institut
series	Beilstein Journal of Organic Chemistry
issn	1860-5397
publishDate	2015-12-01
description	A novel and practical asymmetric synthesis of dapoxetine hydrochloride by using the chiral auxiliary (S)-tert-butanesulfinamide was explored. The synthesis was concise, mild, and easy to perform. The overall yield and stereoselectivity were excellent.
topic	asymmetric synthesis dapoxetine hydrochloride stereoselectivity (S)-tert-butanesulfinamide
url	https://doi.org/10.3762/bjoc.11.283
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A novel and practical asymmetric synthesis of dapoxetine hydrochloride

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