A novel and practical asymmetric synthesis of dapoxetine hydrochloride
A novel and practical asymmetric synthesis of dapoxetine hydrochloride by using the chiral auxiliary (S)-tert-butanesulfinamide was explored. The synthesis was concise, mild, and easy to perform. The overall yield and stereoselectivity were excellent.
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Series: | Beilstein Journal of Organic Chemistry |
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Online Access: | https://doi.org/10.3762/bjoc.11.283 |
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doaj-589968f897e34e4aa68d80bee6e2c76f2021-02-02T06:59:31ZengBeilstein-InstitutBeilstein Journal of Organic Chemistry1860-53972015-12-011112641264510.3762/bjoc.11.2831860-5397-11-283A novel and practical asymmetric synthesis of dapoxetine hydrochlorideYijun Zhu0Zhenren Liu1Hongyan Li2Deyong Ye3Weicheng Zhou4State Key Lab of New Drug & Pharmaceutical Process, Shanghai Key Lab of Anti-Infectives, State Institute of Pharmaceutical Industry, No. 285, Gebaini Rd., Shanghai 201203, ChinaState Key Lab of New Drug & Pharmaceutical Process, Shanghai Key Lab of Anti-Infectives, State Institute of Pharmaceutical Industry, No. 285, Gebaini Rd., Shanghai 201203, ChinaState Key Lab of New Drug & Pharmaceutical Process, Shanghai Key Lab of Anti-Infectives, State Institute of Pharmaceutical Industry, No. 285, Gebaini Rd., Shanghai 201203, ChinaSchool of Pharmacy, Fudan University, No. 826, Zhangheng Rd., Shanghai 201203, ChinaState Key Lab of New Drug & Pharmaceutical Process, Shanghai Key Lab of Anti-Infectives, State Institute of Pharmaceutical Industry, No. 285, Gebaini Rd., Shanghai 201203, ChinaA novel and practical asymmetric synthesis of dapoxetine hydrochloride by using the chiral auxiliary (S)-tert-butanesulfinamide was explored. The synthesis was concise, mild, and easy to perform. The overall yield and stereoselectivity were excellent.https://doi.org/10.3762/bjoc.11.283asymmetric synthesisdapoxetine hydrochloridestereoselectivity(S)-tert-butanesulfinamide |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yijun Zhu Zhenren Liu Hongyan Li Deyong Ye Weicheng Zhou |
spellingShingle |
Yijun Zhu Zhenren Liu Hongyan Li Deyong Ye Weicheng Zhou A novel and practical asymmetric synthesis of dapoxetine hydrochloride Beilstein Journal of Organic Chemistry asymmetric synthesis dapoxetine hydrochloride stereoselectivity (S)-tert-butanesulfinamide |
author_facet |
Yijun Zhu Zhenren Liu Hongyan Li Deyong Ye Weicheng Zhou |
author_sort |
Yijun Zhu |
title |
A novel and practical asymmetric synthesis of dapoxetine hydrochloride |
title_short |
A novel and practical asymmetric synthesis of dapoxetine hydrochloride |
title_full |
A novel and practical asymmetric synthesis of dapoxetine hydrochloride |
title_fullStr |
A novel and practical asymmetric synthesis of dapoxetine hydrochloride |
title_full_unstemmed |
A novel and practical asymmetric synthesis of dapoxetine hydrochloride |
title_sort |
novel and practical asymmetric synthesis of dapoxetine hydrochloride |
publisher |
Beilstein-Institut |
series |
Beilstein Journal of Organic Chemistry |
issn |
1860-5397 |
publishDate |
2015-12-01 |
description |
A novel and practical asymmetric synthesis of dapoxetine hydrochloride by using the chiral auxiliary (S)-tert-butanesulfinamide was explored. The synthesis was concise, mild, and easy to perform. The overall yield and stereoselectivity were excellent. |
topic |
asymmetric synthesis dapoxetine hydrochloride stereoselectivity (S)-tert-butanesulfinamide |
url |
https://doi.org/10.3762/bjoc.11.283 |
work_keys_str_mv |
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1724300205894926336 |