SARS-CoV-2 in severe COVID-19 induces a TGF-β-dominated chronic immune response that does not target itself
Our understanding on the humoral immunity induced by SARS-CoV-2 is still lacking. Here the authors analyze B cell responses at the single cell level to find that, in severe COVID-19 patients, plasmablasts shift from IFN to TGFβ instruction to produce IgA antibodies that are not specific to dominant...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2021-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-22210-3 |
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doaj-58a67a60b8ae4622829438abe4d63e7c |
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| record_format |
Article |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Marta Ferreira-Gomes Andrey Kruglov Pawel Durek Frederik Heinrich Caroline Tizian Gitta Anne Heinz Anna Pascual-Reguant Weijie Du Ronja Mothes Chaofan Fan Stefan Frischbutter Katharina Habenicht Lisa Budzinski Justus Ninnemann Peter K. Jani Gabriela Maria Guerra Katrin Lehmann Mareen Matz Lennard Ostendorf Lukas Heiberger Hyun-Dong Chang Sandy Bauherr Marcus Maurer Günther Schönrich Martin Raftery Tilmann Kallinich Marcus Alexander Mall Stefan Angermair Sascha Treskatsch Thomas Dörner Victor Max Corman Andreas Diefenbach Hans-Dieter Volk Sefer Elezkurtaj Thomas H. Winkler Jun Dong Anja Erika Hauser Helena Radbruch Mario Witkowski Fritz Melchers Andreas Radbruch Mir-Farzin Mashreghi |
| spellingShingle |
Marta Ferreira-Gomes Andrey Kruglov Pawel Durek Frederik Heinrich Caroline Tizian Gitta Anne Heinz Anna Pascual-Reguant Weijie Du Ronja Mothes Chaofan Fan Stefan Frischbutter Katharina Habenicht Lisa Budzinski Justus Ninnemann Peter K. Jani Gabriela Maria Guerra Katrin Lehmann Mareen Matz Lennard Ostendorf Lukas Heiberger Hyun-Dong Chang Sandy Bauherr Marcus Maurer Günther Schönrich Martin Raftery Tilmann Kallinich Marcus Alexander Mall Stefan Angermair Sascha Treskatsch Thomas Dörner Victor Max Corman Andreas Diefenbach Hans-Dieter Volk Sefer Elezkurtaj Thomas H. Winkler Jun Dong Anja Erika Hauser Helena Radbruch Mario Witkowski Fritz Melchers Andreas Radbruch Mir-Farzin Mashreghi SARS-CoV-2 in severe COVID-19 induces a TGF-β-dominated chronic immune response that does not target itself Nature Communications |
| author_facet |
Marta Ferreira-Gomes Andrey Kruglov Pawel Durek Frederik Heinrich Caroline Tizian Gitta Anne Heinz Anna Pascual-Reguant Weijie Du Ronja Mothes Chaofan Fan Stefan Frischbutter Katharina Habenicht Lisa Budzinski Justus Ninnemann Peter K. Jani Gabriela Maria Guerra Katrin Lehmann Mareen Matz Lennard Ostendorf Lukas Heiberger Hyun-Dong Chang Sandy Bauherr Marcus Maurer Günther Schönrich Martin Raftery Tilmann Kallinich Marcus Alexander Mall Stefan Angermair Sascha Treskatsch Thomas Dörner Victor Max Corman Andreas Diefenbach Hans-Dieter Volk Sefer Elezkurtaj Thomas H. Winkler Jun Dong Anja Erika Hauser Helena Radbruch Mario Witkowski Fritz Melchers Andreas Radbruch Mir-Farzin Mashreghi |
| author_sort |
Marta Ferreira-Gomes |
| title |
SARS-CoV-2 in severe COVID-19 induces a TGF-β-dominated chronic immune response that does not target itself |
| title_short |
SARS-CoV-2 in severe COVID-19 induces a TGF-β-dominated chronic immune response that does not target itself |
| title_full |
SARS-CoV-2 in severe COVID-19 induces a TGF-β-dominated chronic immune response that does not target itself |
| title_fullStr |
SARS-CoV-2 in severe COVID-19 induces a TGF-β-dominated chronic immune response that does not target itself |
| title_full_unstemmed |
SARS-CoV-2 in severe COVID-19 induces a TGF-β-dominated chronic immune response that does not target itself |
| title_sort |
sars-cov-2 in severe covid-19 induces a tgf-β-dominated chronic immune response that does not target itself |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2021-03-01 |
| description |
Our understanding on the humoral immunity induced by SARS-CoV-2 is still lacking. Here the authors analyze B cell responses at the single cell level to find that, in severe COVID-19 patients, plasmablasts shift from IFN to TGFβ instruction to produce IgA antibodies that are not specific to dominant SARS-CoV-2 antigens. |
| url |
https://doi.org/10.1038/s41467-021-22210-3 |
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doaj-58a67a60b8ae4622829438abe4d63e7c2021-04-04T11:12:59ZengNature Publishing GroupNature Communications2041-17232021-03-0112111410.1038/s41467-021-22210-3SARS-CoV-2 in severe COVID-19 induces a TGF-β-dominated chronic immune response that does not target itselfMarta Ferreira-Gomes0Andrey Kruglov1Pawel Durek2Frederik Heinrich3Caroline Tizian4Gitta Anne Heinz5Anna Pascual-Reguant6Weijie Du7Ronja Mothes8Chaofan Fan9Stefan Frischbutter10Katharina Habenicht11Lisa Budzinski12Justus Ninnemann13Peter K. Jani14Gabriela Maria Guerra15Katrin Lehmann16Mareen Matz17Lennard Ostendorf18Lukas Heiberger19Hyun-Dong Chang20Sandy Bauherr21Marcus Maurer22Günther Schönrich23Martin Raftery24Tilmann Kallinich25Marcus Alexander Mall26Stefan Angermair27Sascha Treskatsch28Thomas Dörner29Victor Max Corman30Andreas Diefenbach31Hans-Dieter Volk32Sefer Elezkurtaj33Thomas H. Winkler34Jun Dong35Anja Erika Hauser36Helena Radbruch37Mario Witkowski38Fritz Melchers39Andreas Radbruch40Mir-Farzin Mashreghi41Deutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz AssociationDeutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz AssociationDeutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz AssociationDeutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz AssociationLaboratory of Innate Immunity, Department of Microbiology and Infection Immunology, Charité-Universitätsmedizin BerlinDeutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz AssociationDeutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz AssociationDeutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz AssociationDeutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz AssociationDeutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz AssociationDermatological Allergology, Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of HealthFriedrich-Alexander-University Erlangen-NurembergDeutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz AssociationDeutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz AssociationDeutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz AssociationDeutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz AssociationDeutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz AssociationBIH Center for Regenerative Therapies (BCRT), Charité Universitätsmedizin BerlinDeutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz AssociationDeutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz AssociationDeutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz AssociationDeutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz AssociationDermatological Allergology, Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of HealthInstitute of Virology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of HealthInstitute of Virology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of HealthDeutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz AssociationBerlin Institute of Health (BIH)Department of Anesthesiology and Intensive Care Medicine, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of HealthDepartment of Anesthesiology and Intensive Care Medicine, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of HealthDeutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz AssociationInstitute of Virology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of HealthLaboratory of Innate Immunity, Department of Microbiology and Infection Immunology, Charité-Universitätsmedizin BerlinBIH Center for Regenerative Therapies (BCRT), Charité Universitätsmedizin BerlinInstitute of Pathology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of HealthFriedrich-Alexander-University Erlangen-NurembergDeutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz AssociationDeutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz AssociationDepartment of Neuropathology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of HealthLaboratory of Innate Immunity, Department of Microbiology and Infection Immunology, Charité-Universitätsmedizin BerlinDeutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz AssociationDeutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz AssociationDeutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz AssociationOur understanding on the humoral immunity induced by SARS-CoV-2 is still lacking. Here the authors analyze B cell responses at the single cell level to find that, in severe COVID-19 patients, plasmablasts shift from IFN to TGFβ instruction to produce IgA antibodies that are not specific to dominant SARS-CoV-2 antigens.https://doi.org/10.1038/s41467-021-22210-3 |