SARS-CoV-2 in severe COVID-19 induces a TGF-β-dominated chronic immune response that does not target itself

SARS-CoV-2 in severe COVID-19 induces a TGF-β-dominated chronic immune response that does not target itself

Our understanding on the humoral immunity induced by SARS-CoV-2 is still lacking. Here the authors analyze B cell responses at the single cell level to find that, in severe COVID-19 patients, plasmablasts shift from IFN to TGFβ instruction to produce IgA antibodies that are not specific to dominant...

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Bibliographic Details
Main Authors: Marta Ferreira-Gomes, Andrey Kruglov, Pawel Durek, Frederik Heinrich, Caroline Tizian, Gitta Anne Heinz, Anna Pascual-Reguant, Weijie Du, Ronja Mothes, Chaofan Fan, Stefan Frischbutter, Katharina Habenicht, Lisa Budzinski, Justus Ninnemann, Peter K. Jani, Gabriela Maria Guerra, Katrin Lehmann, Mareen Matz, Lennard Ostendorf, Lukas Heiberger, Hyun-Dong Chang, Sandy Bauherr, Marcus Maurer, Günther Schönrich, Martin Raftery, Tilmann Kallinich, Marcus Alexander Mall, Stefan Angermair, Sascha Treskatsch, Thomas Dörner, Victor Max Corman, Andreas Diefenbach, Hans-Dieter Volk, Sefer Elezkurtaj, Thomas H. Winkler, Jun Dong, Anja Erika Hauser, Helena Radbruch, Mario Witkowski, Fritz Melchers, Andreas Radbruch, Mir-Farzin Mashreghi
Format: Article
Language:English
Published: Nature Publishing Group 2021-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-22210-3

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