Adenoma-carcinoma Sequence in the Bladder After Augmentation Cystoplasty

• Main Authors: Akihiro Naito, Taketo Kawai, Tetsuya Fujimura, Teppei Morikawa, Haruki Kume, Yukio Homma
• Format: Article
• Language: English
• Published: Elsevier 2014-05-01
• Series: Urology Case Reports
• Subjects: Augmentation cystoplasty; Tubulovillous adenoma; Adenoma-carcinoma sequence; Multistep carcinogenesis
• Online Access: http://www.sciencedirect.com/science/article/pii/S2214442014000230

We present a case of a 64-year-old woman showing multistep progression from adenoma to adenocarcinoma in the bladder 46 years after augmentation ileocystoplasty. She underwent augmentation ileocystoplasty for tuberculous contracted bladder at 18 years. After 44 years, tubulovillous adenomas were found and resected at the ileovesical anastomosis site. After 2 more years, bladder tumors recurred and revealed adenocarcinomas. Finally, radical cystectomy was required because of frequent recurrence and tumor extensiveness. To our knowledge, this is the first case demonstrating adenoma-carcinoma sequence histopathologically in the bladder after augmentation cystoplasty, indicating multistep carcinogenesis similar to intestinal carcinogenesis.