Adenoma-carcinoma Sequence in the Bladder After Augmentation Cystoplasty
We present a case of a 64-year-old woman showing multistep progression from adenoma to adenocarcinoma in the bladder 46 years after augmentation ileocystoplasty. She underwent augmentation ileocystoplasty for tuberculous contracted bladder at 18 years. After 44 years, tubulovillous adenomas were fou...
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doaj-58a7ab453d1b4ff09d67d5f9fa095c532020-11-24T21:11:43ZengElsevierUrology Case Reports2214-44202014-05-0123737410.1016/j.eucr.2014.01.009Adenoma-carcinoma Sequence in the Bladder After Augmentation CystoplastyAkihiro Naito0Taketo Kawai1Tetsuya Fujimura2Teppei Morikawa3Haruki Kume4Yukio Homma5Department of Urology, Graduate School of Medicine, The University of Tokyo, Tokyo, JapanDepartment of Urology, Graduate School of Medicine, The University of Tokyo, Tokyo, JapanDepartment of Urology, Graduate School of Medicine, The University of Tokyo, Tokyo, JapanDepartment of Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, JapanDepartment of Urology, Graduate School of Medicine, The University of Tokyo, Tokyo, JapanDepartment of Urology, Graduate School of Medicine, The University of Tokyo, Tokyo, JapanWe present a case of a 64-year-old woman showing multistep progression from adenoma to adenocarcinoma in the bladder 46 years after augmentation ileocystoplasty. She underwent augmentation ileocystoplasty for tuberculous contracted bladder at 18 years. After 44 years, tubulovillous adenomas were found and resected at the ileovesical anastomosis site. After 2 more years, bladder tumors recurred and revealed adenocarcinomas. Finally, radical cystectomy was required because of frequent recurrence and tumor extensiveness. To our knowledge, this is the first case demonstrating adenoma-carcinoma sequence histopathologically in the bladder after augmentation cystoplasty, indicating multistep carcinogenesis similar to intestinal carcinogenesis.http://www.sciencedirect.com/science/article/pii/S2214442014000230Augmentation cystoplastyTubulovillous adenomaAdenoma-carcinoma sequenceMultistep carcinogenesis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Akihiro Naito Taketo Kawai Tetsuya Fujimura Teppei Morikawa Haruki Kume Yukio Homma |
spellingShingle |
Akihiro Naito Taketo Kawai Tetsuya Fujimura Teppei Morikawa Haruki Kume Yukio Homma Adenoma-carcinoma Sequence in the Bladder After Augmentation Cystoplasty Urology Case Reports Augmentation cystoplasty Tubulovillous adenoma Adenoma-carcinoma sequence Multistep carcinogenesis |
author_facet |
Akihiro Naito Taketo Kawai Tetsuya Fujimura Teppei Morikawa Haruki Kume Yukio Homma |
author_sort |
Akihiro Naito |
title |
Adenoma-carcinoma Sequence in the Bladder After Augmentation Cystoplasty |
title_short |
Adenoma-carcinoma Sequence in the Bladder After Augmentation Cystoplasty |
title_full |
Adenoma-carcinoma Sequence in the Bladder After Augmentation Cystoplasty |
title_fullStr |
Adenoma-carcinoma Sequence in the Bladder After Augmentation Cystoplasty |
title_full_unstemmed |
Adenoma-carcinoma Sequence in the Bladder After Augmentation Cystoplasty |
title_sort |
adenoma-carcinoma sequence in the bladder after augmentation cystoplasty |
publisher |
Elsevier |
series |
Urology Case Reports |
issn |
2214-4420 |
publishDate |
2014-05-01 |
description |
We present a case of a 64-year-old woman showing multistep progression from adenoma to adenocarcinoma in the bladder 46 years after augmentation ileocystoplasty. She underwent augmentation ileocystoplasty for tuberculous contracted bladder at 18 years. After 44 years, tubulovillous adenomas were found and resected at the ileovesical anastomosis site. After 2 more years, bladder tumors recurred and revealed adenocarcinomas. Finally, radical cystectomy was required because of frequent recurrence and tumor extensiveness. To our knowledge, this is the first case demonstrating adenoma-carcinoma sequence histopathologically in the bladder after augmentation cystoplasty, indicating multistep carcinogenesis similar to intestinal carcinogenesis. |
topic |
Augmentation cystoplasty Tubulovillous adenoma Adenoma-carcinoma sequence Multistep carcinogenesis |
url |
http://www.sciencedirect.com/science/article/pii/S2214442014000230 |
work_keys_str_mv |
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1716752953312804864 |