Role and regulation of RUNX2 in osteogenesis

Role and regulation of RUNX2 in osteogenesis

Runt-related transcription factor 2 (RUNX2) is a transcription factor closely associated with the osteoblast phenotype. While frequently referred to, the complexity of its regulation and its interactions within the osteoblast differentiation pathway are often overlooked. This review aims to summaris...

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Bibliographic Details
Main Authors: M Bruderer, RG Richards, M Alini, MJ Stoddart
Format: Article
Language:English
Published: AO Research Institute Davos 2014-10-01
Series:European Cells & Materials
Subjects:
Stem cells
bone
osteogenesis
differentiation
transcription factor
RUNX2
Online Access:http://www.ecmjournal.org/journal/papers/vol028/pdf/v028a19.pdf
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spelling doaj-58b3f9738fb84092888f7c293c3928602020-11-24T22:29:58Zeng AO Research Institute DavosEuropean Cells & Materials1473-22622014-10-0128269286Role and regulation of RUNX2 in osteogenesisM BrudererRG RichardsM AliniMJ Stoddart0AO Research Institute Davos, Clavadelerstrasse 8, CH-7270 Davos Platz, SwitzerlandRunt-related transcription factor 2 (RUNX2) is a transcription factor closely associated with the osteoblast phenotype. While frequently referred to, the complexity of its regulation and its interactions within the osteoblast differentiation pathway are often overlooked. This review aims to summarise the knowledge of its regulation at the transcriptional, translational and post-translational level. In addition, the regulation of RUNX2 by factors commonly used during osteogenic studies will be discussed.http://www.ecmjournal.org/journal/papers/vol028/pdf/v028a19.pdfStem cellsboneosteogenesisdifferentiationtranscription factorRUNX2
collection DOAJ
language English
format Article
sources DOAJ
author M Bruderer
RG Richards
M Alini
MJ Stoddart
spellingShingle M Bruderer
RG Richards
M Alini
MJ Stoddart
Role and regulation of RUNX2 in osteogenesis
European Cells & Materials
Stem cells
bone
osteogenesis
differentiation
transcription factor
RUNX2
author_facet M Bruderer
RG Richards
M Alini
MJ Stoddart
author_sort M Bruderer
title Role and regulation of RUNX2 in osteogenesis
title_short Role and regulation of RUNX2 in osteogenesis
title_full Role and regulation of RUNX2 in osteogenesis
title_fullStr Role and regulation of RUNX2 in osteogenesis
title_full_unstemmed Role and regulation of RUNX2 in osteogenesis
title_sort role and regulation of runx2 in osteogenesis
publisher AO Research Institute Davos
series European Cells & Materials
issn 1473-2262
publishDate 2014-10-01
description Runt-related transcription factor 2 (RUNX2) is a transcription factor closely associated with the osteoblast phenotype. While frequently referred to, the complexity of its regulation and its interactions within the osteoblast differentiation pathway are often overlooked. This review aims to summarise the knowledge of its regulation at the transcriptional, translational and post-translational level. In addition, the regulation of RUNX2 by factors commonly used during osteogenic studies will be discussed.
topic Stem cells
bone
osteogenesis
differentiation
transcription factor
RUNX2
url http://www.ecmjournal.org/journal/papers/vol028/pdf/v028a19.pdf
work_keys_str_mv AT mbruderer roleandregulationofrunx2inosteogenesis
AT rgrichards roleandregulationofrunx2inosteogenesis
AT malini roleandregulationofrunx2inosteogenesis
AT mjstoddart roleandregulationofrunx2inosteogenesis
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