The Poly-E motif in Titin's PEVK region undergoes pH dependent conformational changes
The muscle protein titin plays a crucial role in passive elasticity and the disordered PEVK region within titin is central to that function. The PEVK region is so named due to its high proline, glutamate, valine and lysine content and the high charge density in this region results in a lack of organ...
Main Authors: | Dassanayake Mudiyanselage Sudarshi Premawardhana, Fang Zhang, Jin Xu, Matthew J. Gage |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2020-12-01
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Series: | Biochemistry and Biophysics Reports |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2405580820301692 |
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