Interactome analysis reveals that lncRNA HULC promotes aerobic glycolysis through LDHA and PKM2
Here the authors present a quantitative proteomics strategy to identify long noncoding RNA (lncRNA)-binding proteins and demonstrate its application by characterizing the lncRNA HULC (highly upregulated in liver cancer), which is shown to interact with glycolytic enzymes and modulate their activity.
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Nature Publishing Group
2020-06-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-020-16966-3 |
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doaj-58b674cabf754f57b4d676cdce0c36dd2021-06-27T11:14:22ZengNature Publishing GroupNature Communications2041-17232020-06-0111111510.1038/s41467-020-16966-3Interactome analysis reveals that lncRNA HULC promotes aerobic glycolysis through LDHA and PKM2Chunqing Wang0Yongmei Li1Shuai Yan2Hao Wang3Xianfeng Shao4Mingming Xiao5Baicai Yang6Guoxuan Qin7Ruirui Kong8Ruibing Chen9Ning Zhang10Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin’s Clinical Research Center for Cancer, Tianjin Medical UniversityDepartment of Pathogen Biology, School of Basic Medical Sciences, Tianjin Medical UniversityDepartment of Genetics, School of Basic Medical Sciences, Tianjin Medical UniversityDepartment of Genetics, School of Basic Medical Sciences, Tianjin Medical UniversityDepartment of Genetics, School of Basic Medical Sciences, Tianjin Medical UniversityTianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin’s Clinical Research Center for Cancer, Tianjin Medical UniversityDepartment of Genetics, School of Basic Medical Sciences, Tianjin Medical UniversitySchool of Microelectronics, Tianjin UniversityPeking University First Hospital, Peking University Health Science CenterSchool of Pharmaceutical Science and Technology, Tianjin UniversityTianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin’s Clinical Research Center for Cancer, Tianjin Medical UniversityHere the authors present a quantitative proteomics strategy to identify long noncoding RNA (lncRNA)-binding proteins and demonstrate its application by characterizing the lncRNA HULC (highly upregulated in liver cancer), which is shown to interact with glycolytic enzymes and modulate their activity.https://doi.org/10.1038/s41467-020-16966-3 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Chunqing Wang Yongmei Li Shuai Yan Hao Wang Xianfeng Shao Mingming Xiao Baicai Yang Guoxuan Qin Ruirui Kong Ruibing Chen Ning Zhang |
spellingShingle |
Chunqing Wang Yongmei Li Shuai Yan Hao Wang Xianfeng Shao Mingming Xiao Baicai Yang Guoxuan Qin Ruirui Kong Ruibing Chen Ning Zhang Interactome analysis reveals that lncRNA HULC promotes aerobic glycolysis through LDHA and PKM2 Nature Communications |
author_facet |
Chunqing Wang Yongmei Li Shuai Yan Hao Wang Xianfeng Shao Mingming Xiao Baicai Yang Guoxuan Qin Ruirui Kong Ruibing Chen Ning Zhang |
author_sort |
Chunqing Wang |
title |
Interactome analysis reveals that lncRNA HULC promotes aerobic glycolysis through LDHA and PKM2 |
title_short |
Interactome analysis reveals that lncRNA HULC promotes aerobic glycolysis through LDHA and PKM2 |
title_full |
Interactome analysis reveals that lncRNA HULC promotes aerobic glycolysis through LDHA and PKM2 |
title_fullStr |
Interactome analysis reveals that lncRNA HULC promotes aerobic glycolysis through LDHA and PKM2 |
title_full_unstemmed |
Interactome analysis reveals that lncRNA HULC promotes aerobic glycolysis through LDHA and PKM2 |
title_sort |
interactome analysis reveals that lncrna hulc promotes aerobic glycolysis through ldha and pkm2 |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2020-06-01 |
description |
Here the authors present a quantitative proteomics strategy to identify long noncoding RNA (lncRNA)-binding proteins and demonstrate its application by characterizing the lncRNA HULC (highly upregulated in liver cancer), which is shown to interact with glycolytic enzymes and modulate their activity. |
url |
https://doi.org/10.1038/s41467-020-16966-3 |
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