Interactome analysis reveals that lncRNA HULC promotes aerobic glycolysis through LDHA and PKM2

Interactome analysis reveals that lncRNA HULC promotes aerobic glycolysis through LDHA and PKM2

Here the authors present a quantitative proteomics strategy to identify long noncoding RNA (lncRNA)-binding proteins and demonstrate its application by characterizing the lncRNA HULC (highly upregulated in liver cancer), which is shown to interact with glycolytic enzymes and modulate their activity.

Bibliographic Details
Main Authors: Chunqing Wang, Yongmei Li, Shuai Yan, Hao Wang, Xianfeng Shao, Mingming Xiao, Baicai Yang, Guoxuan Qin, Ruirui Kong, Ruibing Chen, Ning Zhang
Format: Article
Language:English
Published: Nature Publishing Group 2020-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-16966-3
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spelling doaj-58b674cabf754f57b4d676cdce0c36dd2021-06-27T11:14:22ZengNature Publishing GroupNature Communications2041-17232020-06-0111111510.1038/s41467-020-16966-3Interactome analysis reveals that lncRNA HULC promotes aerobic glycolysis through LDHA and PKM2Chunqing Wang0Yongmei Li1Shuai Yan2Hao Wang3Xianfeng Shao4Mingming Xiao5Baicai Yang6Guoxuan Qin7Ruirui Kong8Ruibing Chen9Ning Zhang10Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin’s Clinical Research Center for Cancer, Tianjin Medical UniversityDepartment of Pathogen Biology, School of Basic Medical Sciences, Tianjin Medical UniversityDepartment of Genetics, School of Basic Medical Sciences, Tianjin Medical UniversityDepartment of Genetics, School of Basic Medical Sciences, Tianjin Medical UniversityDepartment of Genetics, School of Basic Medical Sciences, Tianjin Medical UniversityTianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin’s Clinical Research Center for Cancer, Tianjin Medical UniversityDepartment of Genetics, School of Basic Medical Sciences, Tianjin Medical UniversitySchool of Microelectronics, Tianjin UniversityPeking University First Hospital, Peking University Health Science CenterSchool of Pharmaceutical Science and Technology, Tianjin UniversityTianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin’s Clinical Research Center for Cancer, Tianjin Medical UniversityHere the authors present a quantitative proteomics strategy to identify long noncoding RNA (lncRNA)-binding proteins and demonstrate its application by characterizing the lncRNA HULC (highly upregulated in liver cancer), which is shown to interact with glycolytic enzymes and modulate their activity.https://doi.org/10.1038/s41467-020-16966-3
collection DOAJ
language English
format Article
sources DOAJ
author Chunqing Wang
Yongmei Li
Shuai Yan
Hao Wang
Xianfeng Shao
Mingming Xiao
Baicai Yang
Guoxuan Qin
Ruirui Kong
Ruibing Chen
Ning Zhang
spellingShingle Chunqing Wang
Yongmei Li
Shuai Yan
Hao Wang
Xianfeng Shao
Mingming Xiao
Baicai Yang
Guoxuan Qin
Ruirui Kong
Ruibing Chen
Ning Zhang
Interactome analysis reveals that lncRNA HULC promotes aerobic glycolysis through LDHA and PKM2
Nature Communications
author_facet Chunqing Wang
Yongmei Li
Shuai Yan
Hao Wang
Xianfeng Shao
Mingming Xiao
Baicai Yang
Guoxuan Qin
Ruirui Kong
Ruibing Chen
Ning Zhang
author_sort Chunqing Wang
title Interactome analysis reveals that lncRNA HULC promotes aerobic glycolysis through LDHA and PKM2
title_short Interactome analysis reveals that lncRNA HULC promotes aerobic glycolysis through LDHA and PKM2
title_full Interactome analysis reveals that lncRNA HULC promotes aerobic glycolysis through LDHA and PKM2
title_fullStr Interactome analysis reveals that lncRNA HULC promotes aerobic glycolysis through LDHA and PKM2
title_full_unstemmed Interactome analysis reveals that lncRNA HULC promotes aerobic glycolysis through LDHA and PKM2
title_sort interactome analysis reveals that lncrna hulc promotes aerobic glycolysis through ldha and pkm2
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2020-06-01
description Here the authors present a quantitative proteomics strategy to identify long noncoding RNA (lncRNA)-binding proteins and demonstrate its application by characterizing the lncRNA HULC (highly upregulated in liver cancer), which is shown to interact with glycolytic enzymes and modulate their activity.
url https://doi.org/10.1038/s41467-020-16966-3
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