Multi-Acting Mitochondria-Targeted Platinum(IV) Prodrugs of Kiteplatin with α-Lipoic Acid in the Axial Positions

Multi-Acting Mitochondria-Targeted Platinum(IV) Prodrugs of Kiteplatin with α-Lipoic Acid in the Axial Positions

Platinum(II) drugs are activated intracellularly by aquation of the leaving groups and then bind to DNA, forming DNA adducts capable to activate various signal-transduction pathways. Mostly explored in recent years are Pt(IV) complexes which allow the presence of two additional ligands in the axial...

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Bibliographic Details
Main Authors: Salvatore Savino, Cristina Marzano, Valentina Gandin, James D. Hoeschele, Giovanni Natile, Nicola Margiotta
Format: Article
Language:English
Published: MDPI AG 2018-07-01
Series:International Journal of Molecular Sciences
Subjects:
platinum(IV) complexes
cisplatin
kiteplatin
α-lipoic acid
DNA
mitochondria
tumor spheroids
Online Access:http://www.mdpi.com/1422-0067/19/7/2050

Internet

http://www.mdpi.com/1422-0067/19/7/2050

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