Synthesis and Characterization of Some New Cu(II), Ni(II) and Zn(II) Complexes with Salicylidene Thiosemicarbazones: Antibacterial, Antifungal and in Vitro Antileukemia Activity
Thirty two new Cu(II), Ni(II) and Zn(II) complexes (1–32) with salicylidene thiosemicarbazones (H2L1–H2L10) were synthesized. Salicylidene thiosemicarbazones, of general formula (X)N-NH-C(S)-NH(Y), were prepared through the condensation reaction of 2-hydroxybenzaldehyde and its derivatives (X) with...
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doaj-58bccaa817074962ad45349992a63e442020-11-24T23:54:46ZengMDPI AGMolecules1420-30492013-07-011888812883610.3390/molecules18088812Synthesis and Characterization of Some New Cu(II), Ni(II) and Zn(II) Complexes with Salicylidene Thiosemicarbazones: Antibacterial, Antifungal and in Vitro Antileukemia ActivityTudor RosuVictor TapcovDonald PoirierElena PahontuValeriu FalaAurelian GuleaThirty two new Cu(II), Ni(II) and Zn(II) complexes (1–32) with salicylidene thiosemicarbazones (H2L1–H2L10) were synthesized. Salicylidene thiosemicarbazones, of general formula (X)N-NH-C(S)-NH(Y), were prepared through the condensation reaction of 2-hydroxybenzaldehyde and its derivatives (X) with thiosemicarbazide or 4-phenylthiosemicarbazide (Y = H, C6H5). The characterization of the new formed compounds was done by 1H-NMR, 13C-NMR, IR spectroscopy, elemental analysis, magnetochemical, thermoanalytical and molar conductance measurements. In addition, the structure of the complex 5 has been determined by X-ray diffraction method. All ligands and metal complexes were tested as inhibitors of human leukemia (HL-60) cells growth and antibacterial and antifungal activities.http://www.mdpi.com/1420-3049/18/8/8812coppernickelzinc complexesthiosemicarbazonesantimicrobial activityantileukemia |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tudor Rosu Victor Tapcov Donald Poirier Elena Pahontu Valeriu Fala Aurelian Gulea |
spellingShingle |
Tudor Rosu Victor Tapcov Donald Poirier Elena Pahontu Valeriu Fala Aurelian Gulea Synthesis and Characterization of Some New Cu(II), Ni(II) and Zn(II) Complexes with Salicylidene Thiosemicarbazones: Antibacterial, Antifungal and in Vitro Antileukemia Activity Molecules copper nickel zinc complexes thiosemicarbazones antimicrobial activity antileukemia |
author_facet |
Tudor Rosu Victor Tapcov Donald Poirier Elena Pahontu Valeriu Fala Aurelian Gulea |
author_sort |
Tudor Rosu |
title |
Synthesis and Characterization of Some New Cu(II), Ni(II) and Zn(II) Complexes with Salicylidene Thiosemicarbazones: Antibacterial, Antifungal and in Vitro Antileukemia Activity |
title_short |
Synthesis and Characterization of Some New Cu(II), Ni(II) and Zn(II) Complexes with Salicylidene Thiosemicarbazones: Antibacterial, Antifungal and in Vitro Antileukemia Activity |
title_full |
Synthesis and Characterization of Some New Cu(II), Ni(II) and Zn(II) Complexes with Salicylidene Thiosemicarbazones: Antibacterial, Antifungal and in Vitro Antileukemia Activity |
title_fullStr |
Synthesis and Characterization of Some New Cu(II), Ni(II) and Zn(II) Complexes with Salicylidene Thiosemicarbazones: Antibacterial, Antifungal and in Vitro Antileukemia Activity |
title_full_unstemmed |
Synthesis and Characterization of Some New Cu(II), Ni(II) and Zn(II) Complexes with Salicylidene Thiosemicarbazones: Antibacterial, Antifungal and in Vitro Antileukemia Activity |
title_sort |
synthesis and characterization of some new cu(ii), ni(ii) and zn(ii) complexes with salicylidene thiosemicarbazones: antibacterial, antifungal and in vitro antileukemia activity |
publisher |
MDPI AG |
series |
Molecules |
issn |
1420-3049 |
publishDate |
2013-07-01 |
description |
Thirty two new Cu(II), Ni(II) and Zn(II) complexes (1–32) with salicylidene thiosemicarbazones (H2L1–H2L10) were synthesized. Salicylidene thiosemicarbazones, of general formula (X)N-NH-C(S)-NH(Y), were prepared through the condensation reaction of 2-hydroxybenzaldehyde and its derivatives (X) with thiosemicarbazide or 4-phenylthiosemicarbazide (Y = H, C6H5). The characterization of the new formed compounds was done by 1H-NMR, 13C-NMR, IR spectroscopy, elemental analysis, magnetochemical, thermoanalytical and molar conductance measurements. In addition, the structure of the complex 5 has been determined by X-ray diffraction method. All ligands and metal complexes were tested as inhibitors of human leukemia (HL-60) cells growth and antibacterial and antifungal activities. |
topic |
copper nickel zinc complexes thiosemicarbazones antimicrobial activity antileukemia |
url |
http://www.mdpi.com/1420-3049/18/8/8812 |
work_keys_str_mv |
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