Meta-analysis of Nicorandil effectiveness on myocardial protection after percutaneous coronary intervention
Abstract Background Using the current meta-analysis as well as systematic review, to determine the curative effect of Nicorandil in comparison of no Nicorandil after elective percutaneous coronary intervention(PCI) on patients. Methods Published literatures were identified via a computerized literat...
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doaj-58c797f561784c51a6c4908e358154d02020-11-25T03:35:19ZengBMCBMC Cardiovascular Disorders1471-22612019-06-0119111010.1186/s12872-019-1071-xMeta-analysis of Nicorandil effectiveness on myocardial protection after percutaneous coronary interventionXiao-Tao Zhao0Chun-Fei Zhang1Qing-Jie Liu2Department of Cardiology, Beijing Chao-Yang Hospital, Captial Medical UniversityDepartment of Internal Medicine, General Political Department Hospital of Chinese PLANational Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Chinese Center for Medical Response to Radiation EmergencyAbstract Background Using the current meta-analysis as well as systematic review, to determine the curative effect of Nicorandil in comparison of no Nicorandil after elective percutaneous coronary intervention(PCI) on patients. Methods Published literatures were identified via a computerized literature search of CENTRAL, PubMed, Cochrane, Embase Databases of Systematic Reviews. A set of randomized trials evaluating Nicorandil in comparison of no Nicorandil administered following PCI in patients harboring coronary artery disease were included. Outcomes were revealed based on the following parameters: peak creatine kinase-MB (CK-MB) value, left ventricular ejection fraction (LVEF), peak troponin I (cTnI), and major adverse cardiovascular events (MACEs) per randomized patients. Results We included a total of 14 RCTs involving 1864 subjects in the present review. According to this meta-analysis, LVEF was significantly improved in Nicorandil group; the peak CK-MB level and the incidence of adverse cardiovascular events were remarkably lower in Nicorandil group. Nicorandil and no Nicorandil administered group appeared to be equivalent with regards to cTnI. Conclusions Nicorandil is effective for patients undergoing elective PCI with coronary artery disease in terms of reducing the incidence of adverse cardiovascular events as well as improving heart function. Nicorandil may exert potential role as a valid and adjunctive therapy accompanied with PCI.http://link.springer.com/article/10.1186/s12872-019-1071-xNicorandilPercutaneous coronary interventionCoronary artery diseaseAcute myocardial infarctionAnginaHeart function |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Xiao-Tao Zhao Chun-Fei Zhang Qing-Jie Liu |
spellingShingle |
Xiao-Tao Zhao Chun-Fei Zhang Qing-Jie Liu Meta-analysis of Nicorandil effectiveness on myocardial protection after percutaneous coronary intervention BMC Cardiovascular Disorders Nicorandil Percutaneous coronary intervention Coronary artery disease Acute myocardial infarction Angina Heart function |
author_facet |
Xiao-Tao Zhao Chun-Fei Zhang Qing-Jie Liu |
author_sort |
Xiao-Tao Zhao |
title |
Meta-analysis of Nicorandil effectiveness on myocardial protection after percutaneous coronary intervention |
title_short |
Meta-analysis of Nicorandil effectiveness on myocardial protection after percutaneous coronary intervention |
title_full |
Meta-analysis of Nicorandil effectiveness on myocardial protection after percutaneous coronary intervention |
title_fullStr |
Meta-analysis of Nicorandil effectiveness on myocardial protection after percutaneous coronary intervention |
title_full_unstemmed |
Meta-analysis of Nicorandil effectiveness on myocardial protection after percutaneous coronary intervention |
title_sort |
meta-analysis of nicorandil effectiveness on myocardial protection after percutaneous coronary intervention |
publisher |
BMC |
series |
BMC Cardiovascular Disorders |
issn |
1471-2261 |
publishDate |
2019-06-01 |
description |
Abstract Background Using the current meta-analysis as well as systematic review, to determine the curative effect of Nicorandil in comparison of no Nicorandil after elective percutaneous coronary intervention(PCI) on patients. Methods Published literatures were identified via a computerized literature search of CENTRAL, PubMed, Cochrane, Embase Databases of Systematic Reviews. A set of randomized trials evaluating Nicorandil in comparison of no Nicorandil administered following PCI in patients harboring coronary artery disease were included. Outcomes were revealed based on the following parameters: peak creatine kinase-MB (CK-MB) value, left ventricular ejection fraction (LVEF), peak troponin I (cTnI), and major adverse cardiovascular events (MACEs) per randomized patients. Results We included a total of 14 RCTs involving 1864 subjects in the present review. According to this meta-analysis, LVEF was significantly improved in Nicorandil group; the peak CK-MB level and the incidence of adverse cardiovascular events were remarkably lower in Nicorandil group. Nicorandil and no Nicorandil administered group appeared to be equivalent with regards to cTnI. Conclusions Nicorandil is effective for patients undergoing elective PCI with coronary artery disease in terms of reducing the incidence of adverse cardiovascular events as well as improving heart function. Nicorandil may exert potential role as a valid and adjunctive therapy accompanied with PCI. |
topic |
Nicorandil Percutaneous coronary intervention Coronary artery disease Acute myocardial infarction Angina Heart function |
url |
http://link.springer.com/article/10.1186/s12872-019-1071-x |
work_keys_str_mv |
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