Oxidant production and SOD1 protein expression in single skeletal myofibers from Down syndrome mice

Down syndrome (DS) is a genetic condition caused by the triplication of chromosome 21. Persons with DS exhibit pronounced muscle weakness, which also occurs in the Ts65Dn mouse model of DS. Oxidative stress is thought to be an underlying factor in the development of DS-related pathologies including...

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Bibliographic Details
Main Authors: Patrick M. Cowley, Divya R. Nair, Lara R. DeRuisseau, Stefan Keslacy, Mustafa Atalay, Keith C. DeRuisseau
Format: Article
Language:English
Published: Elsevier 2017-10-01
Series:Redox Biology
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Online Access:http://www.sciencedirect.com/science/article/pii/S2213231717302574