Hepatotoxicity Effects of Alcohol Consumption during Paracetamol Therapy of Malaria Patients

• Main Authors: Funny Dinge, Sofa D. Alfian, Rizky Abdulah, Sri A. Sumiwi
• Format: Article
• Language: English
• Published: Universitas Padjadjaran 2017-08-01
• Series: Pharmacology and Clinical Pharmacy Research

The risk of paracetamol induced hepatotoxicity could increase with alcohol consumption. Paracetamol was usually given to tropical malaria patients to treat fever. The aim of this study was to determine the hepatotoxicity effect of alcohol consumption in malaria tropica patients receiving paracetamol. This study was a cross-sectional study which was conducted during April-June 2015 at a hospital in Jayapura, Indonesia. The data were obtained from questionnaires and medical records. Alcohol status was determined by Short Michigan Alcoholics Screening Test (SMAST) questionnaire. Level of ALT, AST and bilirubin were observed before and after receiving paracetamol therapy for 5 days. Based on the results, the ALT and bilirubin levels of alcoholic group were higher than in non-alcoholic. However, chi-square test showed that alcohol status did not have a significant influence in ALT, AST, and bilirubin levels. Otherwise, logistic regression analysis showed that age gave a significant effect on AST level (P=0.067). Keywords: alanine aminotransferase (ALT), aspartate aminotransferase (AST), alcohol, malaria