Comparisons of Halogenated β-Nitrostyrenes as Antimicrobial Agents
The influence of three types of halogen-substituted E-β-methyl-β-nitrostyrenes (such as Compounds B, D, H) to overcome bacterial activity that is currently a significant health threat was studied. The evaluations of their bio-potency was measured and related to their structure and activity relations...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2014-08-01
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| Series: | Applied Sciences |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2076-3417/4/3/380 |
| Summary: | The influence of three types of halogen-substituted E-β-methyl-β-nitrostyrenes (such as Compounds B, D, H) to overcome bacterial activity that is currently a significant health threat was studied. The evaluations of their bio-potency was measured and related to their structure and activity relationships for the purposes of serving to inhibit and overcoming resistant microorganisms. In particular, fluorine-containing β-nitrostyrenes were found to be highly active antimicrobial agents. The addition of the β-bromo group enhanced the antibacterial activity significantly. Our work has illustrated that halogen substituents at both the 4-position in the aromatic ring and also at the β-position on the alkene side chain of nitropropenyl arenes enhanced the antimicrobial activity of these compounds. |
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| ISSN: | 2076-3417 |