Ultraviolet Radiation and Basal Cell Carcinoma: An Environmental Perspective
Ultraviolet radiation (UVR) is a known carcinogen participated for the development of skin cancers. Solar UVR exposure, particularly ultraviolet B (UVB), is the mostly significant environmental risk factor for the occurrence and progress of basal cell carcinoma(BCC). Both cumulative and intermittent...
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2021-07-01
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doaj-58ea5db89bc1404d9a3976a136654ac72021-07-22T11:20:19ZengFrontiers Media S.A.Frontiers in Public Health2296-25652021-07-01910.3389/fpubh.2021.666528666528Ultraviolet Radiation and Basal Cell Carcinoma: An Environmental PerspectiveYan Teng0Yong Yu1Sujing Li2Youming Huang3Danfeng Xu4Xiaohua Tao5Yibin Fan6Department of Dermatology, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, ChinaDepartment of Dermatology, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, ChinaBengbu Medical College, Bengbu, ChinaDepartment of Dermatology, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, ChinaDepartment of Dermatology, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, ChinaDepartment of Dermatology, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, ChinaDepartment of Dermatology, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, ChinaUltraviolet radiation (UVR) is a known carcinogen participated for the development of skin cancers. Solar UVR exposure, particularly ultraviolet B (UVB), is the mostly significant environmental risk factor for the occurrence and progress of basal cell carcinoma(BCC). Both cumulative and intermittent high-grade UVR exposure could promote the uncontrolled replication of skin cells. There are also exsiting other contributing environmental factors that combine with the UVR exposure to promote the development of BCC. DNA damage in formation of skin cancers is considered to be a result of UVR toxicity. It is UVR that could activate a series of oncogenes simultaneously inactivating tumor suppressor genes and aberrant proliferation and survival of keratinocytes that repair these damages. Furthermore, mounting evidence demonstrates that inflammatory responses of immune cells in the tumor microenvironment plays crucial role in the skin tumorigenesis as well. In this chapter, we will follow the function of UVR in the onset and development of BCC. We describe the factors that influence BCC induced by UVR, and also review the recent advances of pathogenesis of BCC induced by UVR from the genetic and inflammatory aspects.https://www.frontiersin.org/articles/10.3389/fpubh.2021.666528/fullultraviolet radiationbasal cell carcinomaenvironmentalcontributing factorspathogenesis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yan Teng Yong Yu Sujing Li Youming Huang Danfeng Xu Xiaohua Tao Yibin Fan |
spellingShingle |
Yan Teng Yong Yu Sujing Li Youming Huang Danfeng Xu Xiaohua Tao Yibin Fan Ultraviolet Radiation and Basal Cell Carcinoma: An Environmental Perspective Frontiers in Public Health ultraviolet radiation basal cell carcinoma environmental contributing factors pathogenesis |
author_facet |
Yan Teng Yong Yu Sujing Li Youming Huang Danfeng Xu Xiaohua Tao Yibin Fan |
author_sort |
Yan Teng |
title |
Ultraviolet Radiation and Basal Cell Carcinoma: An Environmental Perspective |
title_short |
Ultraviolet Radiation and Basal Cell Carcinoma: An Environmental Perspective |
title_full |
Ultraviolet Radiation and Basal Cell Carcinoma: An Environmental Perspective |
title_fullStr |
Ultraviolet Radiation and Basal Cell Carcinoma: An Environmental Perspective |
title_full_unstemmed |
Ultraviolet Radiation and Basal Cell Carcinoma: An Environmental Perspective |
title_sort |
ultraviolet radiation and basal cell carcinoma: an environmental perspective |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Public Health |
issn |
2296-2565 |
publishDate |
2021-07-01 |
description |
Ultraviolet radiation (UVR) is a known carcinogen participated for the development of skin cancers. Solar UVR exposure, particularly ultraviolet B (UVB), is the mostly significant environmental risk factor for the occurrence and progress of basal cell carcinoma(BCC). Both cumulative and intermittent high-grade UVR exposure could promote the uncontrolled replication of skin cells. There are also exsiting other contributing environmental factors that combine with the UVR exposure to promote the development of BCC. DNA damage in formation of skin cancers is considered to be a result of UVR toxicity. It is UVR that could activate a series of oncogenes simultaneously inactivating tumor suppressor genes and aberrant proliferation and survival of keratinocytes that repair these damages. Furthermore, mounting evidence demonstrates that inflammatory responses of immune cells in the tumor microenvironment plays crucial role in the skin tumorigenesis as well. In this chapter, we will follow the function of UVR in the onset and development of BCC. We describe the factors that influence BCC induced by UVR, and also review the recent advances of pathogenesis of BCC induced by UVR from the genetic and inflammatory aspects. |
topic |
ultraviolet radiation basal cell carcinoma environmental contributing factors pathogenesis |
url |
https://www.frontiersin.org/articles/10.3389/fpubh.2021.666528/full |
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