Synthesis and biological evaluation of sophocarpinic acid derivatives as anti-HCV agents

Synthesis and biological evaluation of sophocarpinic acid derivatives as anti-HCV agents

Chronic hepatitis C virus (HCV) infection has become a major public health burden worldwide. Twenty-two sophocarpinic acid or matrine derivatives were synthesized and their anti-HCV activities were evaluated in vitro. The structure-activity analysis revealed that (i) sophocarpinic acids with a D-sec...

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Bibliographic Details
Main Authors:	Yinghong Li, Zonggen Peng, Limei Gao, Danqing Song
Format:	Article
Language:	English
Published:	Elsevier 2014-08-01
Series:	Acta Pharmaceutica Sinica B
Subjects:	Sophocarpinic acid Matrine Anti-HCV Antiviral activity Structure−activity relationship
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211383514000549

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