Multidimensional heuristic process for high-yield production of astaxanthin and fragrance molecules in Escherichia coli

Multidimensional heuristic process for high-yield production of astaxanthin and fragrance molecules in Escherichia coli

Achieving high titer yield and productivity of target chemicals in industrial organism depends on multidimensional pathway optimization. Here, the authors use a refined modular method called multidimensional heuristic process to improve production of astaxanthin, nerolidol and linalool in E. coli.

Bibliographic Details
Main Authors: Congqiang Zhang, Vui Yin Seow, Xixian Chen, Heng-Phon Too
Format: Article
Language:English
Published: Nature Publishing Group 2018-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-04211-x
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spelling doaj-58eedeca504a4e0189fa37f9f07a82f92021-05-11T10:26:47ZengNature Publishing GroupNature Communications2041-17232018-05-019111210.1038/s41467-018-04211-xMultidimensional heuristic process for high-yield production of astaxanthin and fragrance molecules in Escherichia coliCongqiang Zhang0Vui Yin Seow1Xixian Chen2Heng-Phon Too3Biotransformation Innovation Platform (BioTrans), Agency for Science, Technology and Research (A*STAR)Department of Biochemistry, National University of SingaporeBiotransformation Innovation Platform (BioTrans), Agency for Science, Technology and Research (A*STAR)Biotransformation Innovation Platform (BioTrans), Agency for Science, Technology and Research (A*STAR)Achieving high titer yield and productivity of target chemicals in industrial organism depends on multidimensional pathway optimization. Here, the authors use a refined modular method called multidimensional heuristic process to improve production of astaxanthin, nerolidol and linalool in E. coli.https://doi.org/10.1038/s41467-018-04211-x
collection DOAJ
language English
format Article
sources DOAJ
author Congqiang Zhang
Vui Yin Seow
Xixian Chen
Heng-Phon Too
spellingShingle Congqiang Zhang
Vui Yin Seow
Xixian Chen
Heng-Phon Too
Multidimensional heuristic process for high-yield production of astaxanthin and fragrance molecules in Escherichia coli
Nature Communications
author_facet Congqiang Zhang
Vui Yin Seow
Xixian Chen
Heng-Phon Too
author_sort Congqiang Zhang
title Multidimensional heuristic process for high-yield production of astaxanthin and fragrance molecules in Escherichia coli
title_short Multidimensional heuristic process for high-yield production of astaxanthin and fragrance molecules in Escherichia coli
title_full Multidimensional heuristic process for high-yield production of astaxanthin and fragrance molecules in Escherichia coli
title_fullStr Multidimensional heuristic process for high-yield production of astaxanthin and fragrance molecules in Escherichia coli
title_full_unstemmed Multidimensional heuristic process for high-yield production of astaxanthin and fragrance molecules in Escherichia coli
title_sort multidimensional heuristic process for high-yield production of astaxanthin and fragrance molecules in escherichia coli
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-05-01
description Achieving high titer yield and productivity of target chemicals in industrial organism depends on multidimensional pathway optimization. Here, the authors use a refined modular method called multidimensional heuristic process to improve production of astaxanthin, nerolidol and linalool in E. coli.
url https://doi.org/10.1038/s41467-018-04211-x
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AT vuiyinseow multidimensionalheuristicprocessforhighyieldproductionofastaxanthinandfragrancemoleculesinescherichiacoli
AT xixianchen multidimensionalheuristicprocessforhighyieldproductionofastaxanthinandfragrancemoleculesinescherichiacoli
AT hengphontoo multidimensionalheuristicprocessforhighyieldproductionofastaxanthinandfragrancemoleculesinescherichiacoli
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