Multidimensional heuristic process for high-yield production of astaxanthin and fragrance molecules in Escherichia coli
Achieving high titer yield and productivity of target chemicals in industrial organism depends on multidimensional pathway optimization. Here, the authors use a refined modular method called multidimensional heuristic process to improve production of astaxanthin, nerolidol and linalool in E. coli.
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Nature Publishing Group
2018-05-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-018-04211-x |
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doaj-58eedeca504a4e0189fa37f9f07a82f92021-05-11T10:26:47ZengNature Publishing GroupNature Communications2041-17232018-05-019111210.1038/s41467-018-04211-xMultidimensional heuristic process for high-yield production of astaxanthin and fragrance molecules in Escherichia coliCongqiang Zhang0Vui Yin Seow1Xixian Chen2Heng-Phon Too3Biotransformation Innovation Platform (BioTrans), Agency for Science, Technology and Research (A*STAR)Department of Biochemistry, National University of SingaporeBiotransformation Innovation Platform (BioTrans), Agency for Science, Technology and Research (A*STAR)Biotransformation Innovation Platform (BioTrans), Agency for Science, Technology and Research (A*STAR)Achieving high titer yield and productivity of target chemicals in industrial organism depends on multidimensional pathway optimization. Here, the authors use a refined modular method called multidimensional heuristic process to improve production of astaxanthin, nerolidol and linalool in E. coli.https://doi.org/10.1038/s41467-018-04211-x |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Congqiang Zhang Vui Yin Seow Xixian Chen Heng-Phon Too |
spellingShingle |
Congqiang Zhang Vui Yin Seow Xixian Chen Heng-Phon Too Multidimensional heuristic process for high-yield production of astaxanthin and fragrance molecules in Escherichia coli Nature Communications |
author_facet |
Congqiang Zhang Vui Yin Seow Xixian Chen Heng-Phon Too |
author_sort |
Congqiang Zhang |
title |
Multidimensional heuristic process for high-yield production of astaxanthin and fragrance molecules in Escherichia coli |
title_short |
Multidimensional heuristic process for high-yield production of astaxanthin and fragrance molecules in Escherichia coli |
title_full |
Multidimensional heuristic process for high-yield production of astaxanthin and fragrance molecules in Escherichia coli |
title_fullStr |
Multidimensional heuristic process for high-yield production of astaxanthin and fragrance molecules in Escherichia coli |
title_full_unstemmed |
Multidimensional heuristic process for high-yield production of astaxanthin and fragrance molecules in Escherichia coli |
title_sort |
multidimensional heuristic process for high-yield production of astaxanthin and fragrance molecules in escherichia coli |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2018-05-01 |
description |
Achieving high titer yield and productivity of target chemicals in industrial organism depends on multidimensional pathway optimization. Here, the authors use a refined modular method called multidimensional heuristic process to improve production of astaxanthin, nerolidol and linalool in E. coli. |
url |
https://doi.org/10.1038/s41467-018-04211-x |
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1721448163832758272 |