Myocardial necrosis markers in myocardial ischemia reperfusion (MI/R) injury: a review
Myocardial ischemia/reperfusion injury is one of the main causes of morbidity and mortality in the world. This injury is experienced by patients suffering from cardiovascular diseases such as coronary heart diseases and subsequently undergoing reperfusion treatments in order to manage the conditions...
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doaj-58f40656f78441cfa966dc170eebfca22020-11-24T21:24:57ZengSociety of TURAZ AKADEMI Medicine Science2147-06342017-03-01611637110.5455/medscience.2016.05.8520235978Myocardial necrosis markers in myocardial ischemia reperfusion (MI/R) injury: a reviewHakan Parlakpinar0Mehmet Hamdi Orum1Onural Ozhan2Inonu University, Faculty of Medicine, Department of Pharmacology, Malatya, Turkey. Inonu University, Faculty of Medicine, Under-graduate Student, Malatya, Turkey. Inonu University, Faculty of Medicine, Department of Pharmacology, Malatya, Turkey.Myocardial ischemia/reperfusion injury is one of the main causes of morbidity and mortality in the world. This injury is experienced by patients suffering from cardiovascular diseases such as coronary heart diseases and subsequently undergoing reperfusion treatments in order to manage the conditions. Ischemia can be especially detrimental to the heart due to its high energy demand. Several cellular alterations have been observed upon the onset of ischemia. The danger created by cardiac ischemia is somewhat paradoxical in that a return of blood to the tissue, termed reperfusion, can result in further damage. The serum markers of myocardial injury are used to help in establishing the diagnosis of myocardial infarction. Use of various biochemical markers, including lactate dehydrogenase (LDH), creatine kinase (CK) total enzyme activity, CK-MB activity, Myoglobin, CK-MB mass, cardiac troponin I (cTnI), and cardiac troponin T (cTnT) have been investigated for noninvasive assessment of reperfusion. It is hoped that further studies will help refine the clinical use of new biomarkers like hs-cTn immunoassays in myocardial injury. [Med-Science 2017; 6(1.000): 163-71]http://www.ejmanager.com/fulltextpdf.php?mno=235978Myocardial ischemia-reperfusioncreatine kinasetroponinmyoglobinlactate dehydrogenaseaspartate amino transferase |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hakan Parlakpinar Mehmet Hamdi Orum Onural Ozhan |
spellingShingle |
Hakan Parlakpinar Mehmet Hamdi Orum Onural Ozhan Myocardial necrosis markers in myocardial ischemia reperfusion (MI/R) injury: a review Medicine Science Myocardial ischemia-reperfusion creatine kinase troponin myoglobin lactate dehydrogenase aspartate amino transferase |
author_facet |
Hakan Parlakpinar Mehmet Hamdi Orum Onural Ozhan |
author_sort |
Hakan Parlakpinar |
title |
Myocardial necrosis markers in myocardial ischemia reperfusion (MI/R) injury: a review |
title_short |
Myocardial necrosis markers in myocardial ischemia reperfusion (MI/R) injury: a review |
title_full |
Myocardial necrosis markers in myocardial ischemia reperfusion (MI/R) injury: a review |
title_fullStr |
Myocardial necrosis markers in myocardial ischemia reperfusion (MI/R) injury: a review |
title_full_unstemmed |
Myocardial necrosis markers in myocardial ischemia reperfusion (MI/R) injury: a review |
title_sort |
myocardial necrosis markers in myocardial ischemia reperfusion (mi/r) injury: a review |
publisher |
Society of TURAZ AKADEMI |
series |
Medicine Science |
issn |
2147-0634 |
publishDate |
2017-03-01 |
description |
Myocardial ischemia/reperfusion injury is one of the main causes of morbidity and mortality in the world. This injury is experienced by patients suffering from cardiovascular diseases such as coronary heart diseases and subsequently undergoing reperfusion treatments in order to manage the conditions. Ischemia can be especially detrimental to the heart due to its high energy demand. Several cellular alterations have been observed upon the onset of ischemia. The danger created by cardiac ischemia is somewhat paradoxical in that a return of blood to the tissue, termed reperfusion, can result in further damage. The serum markers of myocardial injury are used to help in establishing the diagnosis of myocardial infarction. Use of various biochemical markers, including lactate dehydrogenase (LDH), creatine kinase (CK) total enzyme activity, CK-MB activity, Myoglobin, CK-MB mass, cardiac troponin I (cTnI), and cardiac troponin T (cTnT) have been investigated for noninvasive assessment of reperfusion. It is hoped that further studies will help refine the clinical use of new biomarkers like hs-cTn immunoassays in myocardial injury. [Med-Science 2017; 6(1.000): 163-71] |
topic |
Myocardial ischemia-reperfusion creatine kinase troponin myoglobin lactate dehydrogenase aspartate amino transferase |
url |
http://www.ejmanager.com/fulltextpdf.php?mno=235978 |
work_keys_str_mv |
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