Impaired intrinsic functional connectivity between the thalamus and visual cortex in migraine without aura
Abstract Background Resting-state functional magnetic resonance imaging (fMRI) has confirmed disrupted visual network connectivity in migraine without aura (MwoA). The thalamus plays a pivotal role in a number of pain conditions, including migraine. However, the significance of altered thalamo-visua...
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doaj-59107d64a6f240999880f3a76f5e3d5f2020-12-20T12:14:24ZengBMCThe Journal of Headache and Pain1129-23691129-23772019-12-012011910.1186/s10194-019-1065-1Impaired intrinsic functional connectivity between the thalamus and visual cortex in migraine without auraHeng-Le Wei0Xin Zhou1Yu-Chen Chen2Yu-Sheng Yu3Xi Guo4Gang-Ping Zhou5Qing-Qing Zhou6Li-Jie Qu7Xindao Yin8Junrong Li9Hong Zhang10Department of Radiology, The Affiliated Jiangning Hospital of Nanjing Medical UniversityDepartment of Neurology, The Affiliated Jiangning Hospital of Nanjing Medical UniversityDepartment of Radiology, Nanjing First Hospital, Nanjing Medical UniversityDepartment of Radiology, The Affiliated Jiangning Hospital of Nanjing Medical UniversityDepartment of Radiology, The Affiliated Jiangning Hospital of Nanjing Medical UniversityDepartment of Radiology, The Affiliated Jiangning Hospital of Nanjing Medical UniversityDepartment of Radiology, The Affiliated Jiangning Hospital of Nanjing Medical UniversityDepartment of Radiology, The Affiliated Jiangning Hospital of Nanjing Medical UniversityDepartment of Radiology, Nanjing First Hospital, Nanjing Medical UniversityDepartment of Neurology, The Affiliated Jiangning Hospital of Nanjing Medical UniversityDepartment of Radiology, The Affiliated Jiangning Hospital of Nanjing Medical UniversityAbstract Background Resting-state functional magnetic resonance imaging (fMRI) has confirmed disrupted visual network connectivity in migraine without aura (MwoA). The thalamus plays a pivotal role in a number of pain conditions, including migraine. However, the significance of altered thalamo-visual functional connectivity (FC) in migraine remains unknown. The goal of this study was to explore thalamo-visual FC integrity in patients with MwoA and investigate its clinical significance. Methods Resting-state fMRI data were acquired from 33 patients with MwoA and 22 well-matched healthy controls. After identifying the visual network by independent component analysis, we compared neural activation in the visual network and thalamo-visual FC and assessed whether these changes were linked to clinical characteristics. We used voxel-based morphometry to determine whether functional differences were dependent on structural differences. Results The visual network exhibited significant differences in regions (bilateral cunei, right lingual gyrus and left calcarine sulcus) by inter-group comparison. The patients with MwoA showed significantly increased FC between the left thalami and bilateral cunei and between the right thalamus and the contralateral calcarine sulcus and right cuneus. Furthermore, the neural activation of the left calcarine sulcus was positively correlated with visual analogue scale scores (r = 0.319, p = 0.043), and enhanced FC between the left thalamus and right cuneus in migraine patients was negatively correlated with Generalized Anxiety Disorder scores (r = − 0.617, p = 0.005). Conclusion Our data suggest that migraine distress is exacerbated by aberrant feedback projections to the visual network, playing a crucial role in migraine physiological mechanisms. The current study provides further insights into the complex scenario of migraine mechanisms.https://doi.org/10.1186/s10194-019-1065-1MigraineThalamusVisual networkFunctional magnetic resonance imaging |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Heng-Le Wei Xin Zhou Yu-Chen Chen Yu-Sheng Yu Xi Guo Gang-Ping Zhou Qing-Qing Zhou Li-Jie Qu Xindao Yin Junrong Li Hong Zhang |
spellingShingle |
Heng-Le Wei Xin Zhou Yu-Chen Chen Yu-Sheng Yu Xi Guo Gang-Ping Zhou Qing-Qing Zhou Li-Jie Qu Xindao Yin Junrong Li Hong Zhang Impaired intrinsic functional connectivity between the thalamus and visual cortex in migraine without aura The Journal of Headache and Pain Migraine Thalamus Visual network Functional magnetic resonance imaging |
author_facet |
Heng-Le Wei Xin Zhou Yu-Chen Chen Yu-Sheng Yu Xi Guo Gang-Ping Zhou Qing-Qing Zhou Li-Jie Qu Xindao Yin Junrong Li Hong Zhang |
author_sort |
Heng-Le Wei |
title |
Impaired intrinsic functional connectivity between the thalamus and visual cortex in migraine without aura |
title_short |
Impaired intrinsic functional connectivity between the thalamus and visual cortex in migraine without aura |
title_full |
Impaired intrinsic functional connectivity between the thalamus and visual cortex in migraine without aura |
title_fullStr |
Impaired intrinsic functional connectivity between the thalamus and visual cortex in migraine without aura |
title_full_unstemmed |
Impaired intrinsic functional connectivity between the thalamus and visual cortex in migraine without aura |
title_sort |
impaired intrinsic functional connectivity between the thalamus and visual cortex in migraine without aura |
publisher |
BMC |
series |
The Journal of Headache and Pain |
issn |
1129-2369 1129-2377 |
publishDate |
2019-12-01 |
description |
Abstract Background Resting-state functional magnetic resonance imaging (fMRI) has confirmed disrupted visual network connectivity in migraine without aura (MwoA). The thalamus plays a pivotal role in a number of pain conditions, including migraine. However, the significance of altered thalamo-visual functional connectivity (FC) in migraine remains unknown. The goal of this study was to explore thalamo-visual FC integrity in patients with MwoA and investigate its clinical significance. Methods Resting-state fMRI data were acquired from 33 patients with MwoA and 22 well-matched healthy controls. After identifying the visual network by independent component analysis, we compared neural activation in the visual network and thalamo-visual FC and assessed whether these changes were linked to clinical characteristics. We used voxel-based morphometry to determine whether functional differences were dependent on structural differences. Results The visual network exhibited significant differences in regions (bilateral cunei, right lingual gyrus and left calcarine sulcus) by inter-group comparison. The patients with MwoA showed significantly increased FC between the left thalami and bilateral cunei and between the right thalamus and the contralateral calcarine sulcus and right cuneus. Furthermore, the neural activation of the left calcarine sulcus was positively correlated with visual analogue scale scores (r = 0.319, p = 0.043), and enhanced FC between the left thalamus and right cuneus in migraine patients was negatively correlated with Generalized Anxiety Disorder scores (r = − 0.617, p = 0.005). Conclusion Our data suggest that migraine distress is exacerbated by aberrant feedback projections to the visual network, playing a crucial role in migraine physiological mechanisms. The current study provides further insights into the complex scenario of migraine mechanisms. |
topic |
Migraine Thalamus Visual network Functional magnetic resonance imaging |
url |
https://doi.org/10.1186/s10194-019-1065-1 |
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