Different Blood Metabolomics Profiles in Infants Consuming a Meat- or Dairy-Based Complementary Diet
Background: Research is limited in evaluating the mechanisms responsible for infant growth in response to different protein-rich foods; Methods: Targeted and untargeted metabolomics analysis were conducted on serum samples collected from an infant controlled-feeding trial that participants consumed...
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doaj-5912116ab5a84d98bd2c231bd8f9eb4c2021-01-28T00:01:18ZengMDPI AGNutrients2072-66432021-01-011338838810.3390/nu13020388Different Blood Metabolomics Profiles in Infants Consuming a Meat- or Dairy-Based Complementary DietMinghua Tang0Nicholas E. Weaver1Lillian M. Berman2Laura D. Brown3Audrey E. Hendricks4Nancy F. Krebs5Section of Nutrition, Department of Pediatrics, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USADepartment of Mathematical and Statistical Sciences, University of Colorado Denver, Denver, CO 80204, USASection of Nutrition, Department of Pediatrics, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USASection of Neonatology, Department of Pediatrics, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USADepartment of Mathematical and Statistical Sciences, University of Colorado Denver, Denver, CO 80204, USASection of Nutrition, Department of Pediatrics, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USABackground: Research is limited in evaluating the mechanisms responsible for infant growth in response to different protein-rich foods; Methods: Targeted and untargeted metabolomics analysis were conducted on serum samples collected from an infant controlled-feeding trial that participants consumed a meat- vs. dairy-based complementary diet from 5 to 12 months of age, and followed up at 24 months. Results: Isoleucine, valine, phenylalanine increased and threonine decreased over time among all participants; Although none of the individual essential amino acids had a significant impact on changes in growth Z scores from 5 to 12 months, principal component heavily weighted by BCAAs (leucine, isoleucine, valine) and phenylalanine had a positive association with changes in length-for-age Z score from 5 to 12 months. Concentrations of acylcarnitine-C4, acylcarnitine-C5 and acylcarnitine-C5:1 significantly increased over time with the dietary intervention, but none of the acylcarnitines were associated with infant growth Z scores. Quantitative trimethylamine N-oxide increased in the meat group from 5 to 12 months; Conclusions: Our findings suggest that increasing total protein intake by providing protein-rich complementary foods was associated with increased concentrations of certain essential amino acids and short-chain acyl-carnitines. The sources of protein-rich foods (e.g., meat vs. dairy) did not appear to differentially impact serum metabolites, and comprehensive mechanistic investigations are needed to identify other contributors or mediators of the diet-induced infant growth trajectories.https://www.mdpi.com/2072-6643/13/2/388infant nutritionprotein-rich foodsgrowthmetabolomics |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Minghua Tang Nicholas E. Weaver Lillian M. Berman Laura D. Brown Audrey E. Hendricks Nancy F. Krebs |
spellingShingle |
Minghua Tang Nicholas E. Weaver Lillian M. Berman Laura D. Brown Audrey E. Hendricks Nancy F. Krebs Different Blood Metabolomics Profiles in Infants Consuming a Meat- or Dairy-Based Complementary Diet Nutrients infant nutrition protein-rich foods growth metabolomics |
author_facet |
Minghua Tang Nicholas E. Weaver Lillian M. Berman Laura D. Brown Audrey E. Hendricks Nancy F. Krebs |
author_sort |
Minghua Tang |
title |
Different Blood Metabolomics Profiles in Infants Consuming a Meat- or Dairy-Based Complementary Diet |
title_short |
Different Blood Metabolomics Profiles in Infants Consuming a Meat- or Dairy-Based Complementary Diet |
title_full |
Different Blood Metabolomics Profiles in Infants Consuming a Meat- or Dairy-Based Complementary Diet |
title_fullStr |
Different Blood Metabolomics Profiles in Infants Consuming a Meat- or Dairy-Based Complementary Diet |
title_full_unstemmed |
Different Blood Metabolomics Profiles in Infants Consuming a Meat- or Dairy-Based Complementary Diet |
title_sort |
different blood metabolomics profiles in infants consuming a meat- or dairy-based complementary diet |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2021-01-01 |
description |
Background: Research is limited in evaluating the mechanisms responsible for infant growth in response to different protein-rich foods; Methods: Targeted and untargeted metabolomics analysis were conducted on serum samples collected from an infant controlled-feeding trial that participants consumed a meat- vs. dairy-based complementary diet from 5 to 12 months of age, and followed up at 24 months. Results: Isoleucine, valine, phenylalanine increased and threonine decreased over time among all participants; Although none of the individual essential amino acids had a significant impact on changes in growth Z scores from 5 to 12 months, principal component heavily weighted by BCAAs (leucine, isoleucine, valine) and phenylalanine had a positive association with changes in length-for-age Z score from 5 to 12 months. Concentrations of acylcarnitine-C4, acylcarnitine-C5 and acylcarnitine-C5:1 significantly increased over time with the dietary intervention, but none of the acylcarnitines were associated with infant growth Z scores. Quantitative trimethylamine N-oxide increased in the meat group from 5 to 12 months; Conclusions: Our findings suggest that increasing total protein intake by providing protein-rich complementary foods was associated with increased concentrations of certain essential amino acids and short-chain acyl-carnitines. The sources of protein-rich foods (e.g., meat vs. dairy) did not appear to differentially impact serum metabolites, and comprehensive mechanistic investigations are needed to identify other contributors or mediators of the diet-induced infant growth trajectories. |
topic |
infant nutrition protein-rich foods growth metabolomics |
url |
https://www.mdpi.com/2072-6643/13/2/388 |
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