PAGET DISEASE OF THE BREAST – THERAPEUTIC APPROACH DEPENDING ON THE FORM OF PRESENTATION

• Main Authors: Florica Șandru, M.C. Dumitrașcu, Răzvan Petca, Raluca-Gabriela Miulescu, Adelina Popa
• Format: Article
• Language: English
• Published: Editura Universitara Carol Davila 2020-01-01
• Series: Journal of Surgical Sciences
• Subjects: paget disease of the breast; paget cells; breast surgery; total mastectomy
• Online Access: http://journalofsurgicalsciences.com/index.php/jss/article/view/319

The clinical description of the nipple lesion in Paget disease of the breast is of eczematous rash that may be of interest to both the nipple and areola of the same breast, accompanied, most often, by an abundant, clear, slightly yellowish exudate. The first data on Paget's disease were mentioned in 1874, by Sir James Paget, when he pointed out the malignant transformation in the case of ten women with ulceration on eczematous background of the nipple. Paget's disease is rare, accounting for 1-3% of all breast cancer diagnoses. This condition can be encountered in the population between the ages of 26 and 88, but the peak of the incidence is represented by decades 5 and 6 of life. The histopathological examination describes the adenocarcinomatous malignant intraepithelial cells, called Paget cells. The treatment as well as the prognosis in the case of Paget's disease is closely related to the existence of a palpable tumor formation and the presence of mammographic signs of breast malignancy. We present the case of a 59-year-old woman, who presents for a symptomatic, ulcerated tumor formation, with a diameter of about 6 cm, and a 6-month evolution at the level of the upper pole of the areolar complex of the left breast, after previously the nipple at the level of the involved breast underwent changes with erythematous transformation and ulceration.