Teasing apart the cell death pathways in HIV pathogenesis
The progressive loss of CD4 + T cells has been recognised as being central to HIV-1 pathogenesis, however a precise understanding of the underlying mechanisms and, consequently, improved therapies have yet to be achieved. Zhang et al. have recently shown in HIV-1 patients that the NLRP3 inflammasome...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2021-04-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-021-02077-2 |
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doaj-591957e25e714d70998275dc5a8be0732021-04-25T11:29:43ZengNature Publishing GroupCommunications Biology2399-36422021-04-01411110.1038/s42003-021-02077-2Teasing apart the cell death pathways in HIV pathogenesisKarli Montague-Cardoso0Communications BiologyThe progressive loss of CD4 + T cells has been recognised as being central to HIV-1 pathogenesis, however a precise understanding of the underlying mechanisms and, consequently, improved therapies have yet to be achieved. Zhang et al. have recently shown in HIV-1 patients that the NLRP3 inflammasome pathway, which plays a key role in innate immunity, is a crucial mediator of the loss of CD4 + T cells. This advance could inform the development of innovative anti-HIV-1 therapies.https://doi.org/10.1038/s42003-021-02077-2 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Karli Montague-Cardoso |
| spellingShingle |
Karli Montague-Cardoso Teasing apart the cell death pathways in HIV pathogenesis Communications Biology |
| author_facet |
Karli Montague-Cardoso |
| author_sort |
Karli Montague-Cardoso |
| title |
Teasing apart the cell death pathways in HIV pathogenesis |
| title_short |
Teasing apart the cell death pathways in HIV pathogenesis |
| title_full |
Teasing apart the cell death pathways in HIV pathogenesis |
| title_fullStr |
Teasing apart the cell death pathways in HIV pathogenesis |
| title_full_unstemmed |
Teasing apart the cell death pathways in HIV pathogenesis |
| title_sort |
teasing apart the cell death pathways in hiv pathogenesis |
| publisher |
Nature Publishing Group |
| series |
Communications Biology |
| issn |
2399-3642 |
| publishDate |
2021-04-01 |
| description |
The progressive loss of CD4 + T cells has been recognised as being central to HIV-1 pathogenesis, however a precise understanding of the underlying mechanisms and, consequently, improved therapies have yet to be achieved. Zhang et al. have recently shown in HIV-1 patients that the NLRP3 inflammasome pathway, which plays a key role in innate immunity, is a crucial mediator of the loss of CD4 + T cells. This advance could inform the development of innovative anti-HIV-1 therapies. |
| url |
https://doi.org/10.1038/s42003-021-02077-2 |
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