Novel use of a chemically modified siRNA for robust and sustainable in vivo gene silencing in the retina

Abstract Despite efficient and specific in vitro knockdown, more reliable and convenient methods for in vivo knockdown of target genes remain to be developed particularly for retinal research. Using commercially available and chemically modified siRNA so-called Accell siRNA, we established a novel i...

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Bibliographic Details
Main Authors: Takazumi Taniguchi, Ken-ichi Endo, Hidetoshi Tanioka, Masaaki Sasaoka, Kei Tashiro, Shigeru Kinoshita, Masaaki Kageyama
Format: Article
Language:English
Published: Nature Publishing Group 2020-12-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-020-79242-w

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