Synthesis, Characterization of Derivatives Tetrazoles for Trimethoprim Drug

Synthesis, Characterization of Derivatives Tetrazoles for Trimethoprim Drug

The present work involved synthesis of serval new substituted tetrazole via Schiff bases for trimethoprim drug by two steps. The first step involved direct reaction of different ketones and aldehydes with trimethoprim producing the corresponding Schiff bases (1-10), whereas the second step,...

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Bibliographic Details
Main Author: Baghdad Science Journal
Format: Article
Language:Arabic
Published: College of Science for Women, University of Baghdad 2016-06-01
Series:Baghdad Science Journal
Subjects:
"trimethoprim drug, derivatives, tetrazoles, Schiff bases"
Online Access:http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/2772
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spelling doaj-59235b22e536454c9556fb9ab46835262020-11-25T01:59:20ZaraCollege of Science for Women, University of BaghdadBaghdad Science Journal2078-86652411-79862016-06-0113210.21123/bsj.13.2.266-274Synthesis, Characterization of Derivatives Tetrazoles for Trimethoprim DrugBaghdad Science Journal The present work involved synthesis of serval new substituted tetrazole via Schiff bases for trimethoprim drug by two steps. The first step involved direct reaction of different ketones and aldehydes with trimethoprim producing the corresponding Schiff bases (1-10), whereas the second step, involved preparation new tetrazoles derivatives (11-20) through reaction of the ready Schiff bases (in the first step) with sodium azidein in dioxin. The prepared compounds were characterized by UV, FT-IR, and some of them by 13C-NMR, 1H-NMR spectroscopy and physical properties.http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/2772"trimethoprim drug, derivatives, tetrazoles, Schiff bases"
collection DOAJ
language Arabic
format Article
sources DOAJ
author Baghdad Science Journal
spellingShingle Baghdad Science Journal
Synthesis, Characterization of Derivatives Tetrazoles for Trimethoprim Drug
Baghdad Science Journal
"trimethoprim drug, derivatives, tetrazoles, Schiff bases"
author_facet Baghdad Science Journal
author_sort Baghdad Science Journal
title Synthesis, Characterization of Derivatives Tetrazoles for Trimethoprim Drug
title_short Synthesis, Characterization of Derivatives Tetrazoles for Trimethoprim Drug
title_full Synthesis, Characterization of Derivatives Tetrazoles for Trimethoprim Drug
title_fullStr Synthesis, Characterization of Derivatives Tetrazoles for Trimethoprim Drug
title_full_unstemmed Synthesis, Characterization of Derivatives Tetrazoles for Trimethoprim Drug
title_sort synthesis, characterization of derivatives tetrazoles for trimethoprim drug
publisher College of Science for Women, University of Baghdad
series Baghdad Science Journal
issn 2078-8665
2411-7986
publishDate 2016-06-01
description The present work involved synthesis of serval new substituted tetrazole via Schiff bases for trimethoprim drug by two steps. The first step involved direct reaction of different ketones and aldehydes with trimethoprim producing the corresponding Schiff bases (1-10), whereas the second step, involved preparation new tetrazoles derivatives (11-20) through reaction of the ready Schiff bases (in the first step) with sodium azidein in dioxin. The prepared compounds were characterized by UV, FT-IR, and some of them by 13C-NMR, 1H-NMR spectroscopy and physical properties.
topic "trimethoprim drug, derivatives, tetrazoles, Schiff bases"
url http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/2772
work_keys_str_mv AT baghdadsciencejournal synthesischaracterizationofderivativestetrazolesfortrimethoprimdrug
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