Genetic Factors Involved in Cardiomyopathies and in Cancer
Cancer therapy-induced cardiomyopathy (CCM) manifests as left ventricular (LV) dysfunction and heart failure (HF). It is associated withparticular pharmacological agents and it is typically dose dependent, but significant individual variability has been observed. History of prior cardiac disease, ab...
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doaj-5929112e916e4f8d8a14934b430ca8f22020-11-25T03:11:18ZengMDPI AGJournal of Clinical Medicine2077-03832020-06-0191702170210.3390/jcm9061702Genetic Factors Involved in Cardiomyopathies and in CancerMaría Sabater-Molina0Marina Navarro-Peñalver1Carmen Muñoz-Esparza2Ángel Esteban-Gil3Juan Jose Santos-Mateo4Juan R. Gimeno5Unidad de Cardiopatías Hereditarias, Servicio de Cardiología, Hospital Universitario Virgen dela Arrixaca, El Palmar, 30120 Murcia, SpainUnidad de Cardiopatías Hereditarias, Servicio de Cardiología, Hospital Universitario Virgen dela Arrixaca, El Palmar, 30120 Murcia, SpainUnidad de Cardiopatías Hereditarias, Servicio de Cardiología, Hospital Universitario Virgen dela Arrixaca, El Palmar, 30120 Murcia, SpainBiomedical Informatics & Bioinformatics Platform, Institute for Biomedical Research of Murcia (IMIB)/Foundation for Healthcare Training & Research of the Region of Murcia (FFIS), 30003 Murcia, SpainUnidad de Cardiopatías Hereditarias, Servicio de Cardiología, Hospital Universitario Virgen dela Arrixaca, El Palmar, 30120 Murcia, SpainUnidad de Cardiopatías Hereditarias, Servicio de Cardiología, Hospital Universitario Virgen dela Arrixaca, El Palmar, 30120 Murcia, SpainCancer therapy-induced cardiomyopathy (CCM) manifests as left ventricular (LV) dysfunction and heart failure (HF). It is associated withparticular pharmacological agents and it is typically dose dependent, but significant individual variability has been observed. History of prior cardiac disease, abuse of toxics, cardiac overload conditions, age, and genetic predisposing factors modulate the degree of the cardiac reserve and the response to the injury. Genetic/familial cardiomyopathies (CMY) are increasingly recognized in general populations with an estimated prevalence of 1:250. Association between cardiac and oncologic diseases regarding genetics involves not only the toxicity process, but pathogenicity. Genetic variants in germinal cells that cause CMY (LMNA, RAS/MAPK) can increase susceptibility for certain types of cancer. The study of mutations found in cancer cells (somatic) has revealed the implication of genes commonly associated with the development of CMY. In particular, desmosomal mutations have been related to increased undifferentiation and invasiveness of cancer. In this article, the authors review the knowledge on the relevance of environmental and genetic background in CCM and give insights into the shared genetic role in the pathogenicity of the cancer process and development of CMY.https://www.mdpi.com/2077-0383/9/6/1702cardiomyopathycardiotoxicityarrithmogenic cardiomyopathydilated cardiomayopathycancergenetic |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
María Sabater-Molina Marina Navarro-Peñalver Carmen Muñoz-Esparza Ángel Esteban-Gil Juan Jose Santos-Mateo Juan R. Gimeno |
spellingShingle |
María Sabater-Molina Marina Navarro-Peñalver Carmen Muñoz-Esparza Ángel Esteban-Gil Juan Jose Santos-Mateo Juan R. Gimeno Genetic Factors Involved in Cardiomyopathies and in Cancer Journal of Clinical Medicine cardiomyopathy cardiotoxicity arrithmogenic cardiomyopathy dilated cardiomayopathy cancer genetic |
author_facet |
María Sabater-Molina Marina Navarro-Peñalver Carmen Muñoz-Esparza Ángel Esteban-Gil Juan Jose Santos-Mateo Juan R. Gimeno |
author_sort |
María Sabater-Molina |
title |
Genetic Factors Involved in Cardiomyopathies and in Cancer |
title_short |
Genetic Factors Involved in Cardiomyopathies and in Cancer |
title_full |
Genetic Factors Involved in Cardiomyopathies and in Cancer |
title_fullStr |
Genetic Factors Involved in Cardiomyopathies and in Cancer |
title_full_unstemmed |
Genetic Factors Involved in Cardiomyopathies and in Cancer |
title_sort |
genetic factors involved in cardiomyopathies and in cancer |
publisher |
MDPI AG |
series |
Journal of Clinical Medicine |
issn |
2077-0383 |
publishDate |
2020-06-01 |
description |
Cancer therapy-induced cardiomyopathy (CCM) manifests as left ventricular (LV) dysfunction and heart failure (HF). It is associated withparticular pharmacological agents and it is typically dose dependent, but significant individual variability has been observed. History of prior cardiac disease, abuse of toxics, cardiac overload conditions, age, and genetic predisposing factors modulate the degree of the cardiac reserve and the response to the injury. Genetic/familial cardiomyopathies (CMY) are increasingly recognized in general populations with an estimated prevalence of 1:250. Association between cardiac and oncologic diseases regarding genetics involves not only the toxicity process, but pathogenicity. Genetic variants in germinal cells that cause CMY (LMNA, RAS/MAPK) can increase susceptibility for certain types of cancer. The study of mutations found in cancer cells (somatic) has revealed the implication of genes commonly associated with the development of CMY. In particular, desmosomal mutations have been related to increased undifferentiation and invasiveness of cancer. In this article, the authors review the knowledge on the relevance of environmental and genetic background in CCM and give insights into the shared genetic role in the pathogenicity of the cancer process and development of CMY. |
topic |
cardiomyopathy cardiotoxicity arrithmogenic cardiomyopathy dilated cardiomayopathy cancer genetic |
url |
https://www.mdpi.com/2077-0383/9/6/1702 |
work_keys_str_mv |
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