Evolutionary conserved role of c-Jun-N-terminal kinase in CO2-induced epithelial dysfunction.

Evolutionary conserved role of c-Jun-N-terminal kinase in CO2-induced epithelial dysfunction.

Elevated CO(2) levels (hypercapnia) occur in patients with respiratory diseases and impair alveolar epithelial integrity, in part, by inhibiting Na,K-ATPase function. Here, we examined the role of c-Jun N-terminal kinase (JNK) in CO(2) signaling in mammalian alveolar epithelial cells as well as in d...

Full description

Bibliographic Details
Main Authors: István Vadász, Laura A Dada, Arturo Briva, Iiro Taneli Helenius, Kfir Sharabi, Lynn C Welch, Aileen M Kelly, Benno A Grzesik, G R Scott Budinger, Jing Liu, Werner Seeger, Greg J Beitel, Yosef Gruenbaum, Jacob I Sznajder
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3466313?pdf=render

Internet

http://europepmc.org/articles/PMC3466313?pdf=render

Similar Items