Double deletion of PINK1 and Parkin impairs hepatic mitophagy and exacerbates acetaminophen-induced liver injury in mice

Double deletion of PINK1 and Parkin impairs hepatic mitophagy and exacerbates acetaminophen-induced liver injury in mice

Mitochondria damage plays a critical role in acetaminophen (APAP)-induced necrosis and liver injury. Cells can adapt and protect themselves by removing damaged mitochondria via mitophagy. PINK1-Parkin pathway is one of the major pathways that regulate mitophagy but its role in APAP-induced liver inj...

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Bibliographic Details
Main Authors: Hua Wang, Hong-Min Ni, Xiaojuan Chao, Xiaowen Ma, Yssa Ann Rodriguez, Hemantkumar Chavan, Shaogui Wang, Partha Krishnamurthy, Rick Dobrowsky, De-Xiang Xu, Hartmut Jaeschke, Wen-Xing Ding
Format: Article
Language:English
Published: Elsevier 2019-04-01
Series:Redox Biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231718312291

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