Effects of sugammadex on the prevention of postoperative peritoneal adhesions
Many materials and techniques have been used to prevent and repair intra-abdominal adhesions, but an effective solution has not been found. The aim of this study is to research the effect of sugammadex on intra-abdominal adhesions in an experimentally induced intra-abdominal adhesion model. Twenty-f...
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doaj-592fb602e6814a16816f201e067783502020-11-24T21:50:57ZengWileyKaohsiung Journal of Medical Sciences1607-551X2015-09-0131946346710.1016/j.kjms.2015.06.007Effects of sugammadex on the prevention of postoperative peritoneal adhesionsHasan Şahin0Hüseyin Toman1Hasan Ali Kiraz2Tuncer Şimşek3Mesut Erbaş4Faruk Özkul5Muhammet Kasım Arık6Volkan Hancı7Department of Anesthesiology and Reanimation, Medical Faculty, Çanakkale Onsekiz Mart University, Çanakkale, TurkeyDepartment of Anesthesiology and Reanimation, Medical Faculty, Çanakkale Onsekiz Mart University, Çanakkale, TurkeyDepartment of Anesthesiology and Reanimation, Medical Faculty, Çanakkale Onsekiz Mart University, Çanakkale, TurkeyDepartment of Anesthesiology and Reanimation, Medical Faculty, Çanakkale Onsekiz Mart University, Çanakkale, TurkeyDepartment of Anesthesiology and Reanimation, Medical Faculty, Çanakkale Onsekiz Mart University, Çanakkale, TurkeyDepartment of General Surgery, Medical Faculty, Çanakkale Onsekiz Mart University, Çanakkale, TurkeyDepartment of General Surgery, Medical Faculty, Çanakkale Onsekiz Mart University, Çanakkale, TurkeyDepartment of Anesthesiology and Reanimation, Medical Faculty, Dokuz Eylul University, Izmir, TurkeyMany materials and techniques have been used to prevent and repair intra-abdominal adhesions, but an effective solution has not been found. The aim of this study is to research the effect of sugammadex on intra-abdominal adhesions in an experimentally induced intra-abdominal adhesion model. Twenty-four female Wistar albino rats were included in the study. The experimental animals were randomly divided into three groups: the sugammadex group (Group SX, n = 8), the control group (Group C, n = 8), and the sham group (Group S, n = 8). After starvation for 1 night, the rats were injected with a 50 mg/kg intramuscular dose of ketamine and a 5 mg/kg intramuscular dose of xylazine for anesthesia. The rats in the SX group were given 3 mL sugammadex into the peritoneal cavity, while rats in the control group were given 3 mL 0.9% sodium chloride. In the sham group, the peritoneal cavity was opened, but no chemicals were administered. All rats were sacrificed on the 10th postoperative day. The adhesions were staged as 0, 1, 2, and 3 according to Evans et al.'s model. Our evaluation of macroscopic adhesion intensity found statistically significant differences between the groups. The sugammadex group was observed to have fewer adhesions in a statistically significant manner compared with the control group (p < 0.05). In our experimental intra-abdominal adhesion model in rats, we observed that sugammadex prevented postoperative intra-abdominal adhesions.http://www.sciencedirect.com/science/article/pii/S1607551X15001631Experimental studyPeritoneal adhesionRatsSugammadexSurgery |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hasan Şahin Hüseyin Toman Hasan Ali Kiraz Tuncer Şimşek Mesut Erbaş Faruk Özkul Muhammet Kasım Arık Volkan Hancı |
spellingShingle |
Hasan Şahin Hüseyin Toman Hasan Ali Kiraz Tuncer Şimşek Mesut Erbaş Faruk Özkul Muhammet Kasım Arık Volkan Hancı Effects of sugammadex on the prevention of postoperative peritoneal adhesions Kaohsiung Journal of Medical Sciences Experimental study Peritoneal adhesion Rats Sugammadex Surgery |
author_facet |
Hasan Şahin Hüseyin Toman Hasan Ali Kiraz Tuncer Şimşek Mesut Erbaş Faruk Özkul Muhammet Kasım Arık Volkan Hancı |
author_sort |
Hasan Şahin |
title |
Effects of sugammadex on the prevention of postoperative peritoneal adhesions |
title_short |
Effects of sugammadex on the prevention of postoperative peritoneal adhesions |
title_full |
Effects of sugammadex on the prevention of postoperative peritoneal adhesions |
title_fullStr |
Effects of sugammadex on the prevention of postoperative peritoneal adhesions |
title_full_unstemmed |
Effects of sugammadex on the prevention of postoperative peritoneal adhesions |
title_sort |
effects of sugammadex on the prevention of postoperative peritoneal adhesions |
publisher |
Wiley |
series |
Kaohsiung Journal of Medical Sciences |
issn |
1607-551X |
publishDate |
2015-09-01 |
description |
Many materials and techniques have been used to prevent and repair intra-abdominal adhesions, but an effective solution has not been found. The aim of this study is to research the effect of sugammadex on intra-abdominal adhesions in an experimentally induced intra-abdominal adhesion model. Twenty-four female Wistar albino rats were included in the study. The experimental animals were randomly divided into three groups: the sugammadex group (Group SX, n = 8), the control group (Group C, n = 8), and the sham group (Group S, n = 8). After starvation for 1 night, the rats were injected with a 50 mg/kg intramuscular dose of ketamine and a 5 mg/kg intramuscular dose of xylazine for anesthesia. The rats in the SX group were given 3 mL sugammadex into the peritoneal cavity, while rats in the control group were given 3 mL 0.9% sodium chloride. In the sham group, the peritoneal cavity was opened, but no chemicals were administered. All rats were sacrificed on the 10th postoperative day. The adhesions were staged as 0, 1, 2, and 3 according to Evans et al.'s model. Our evaluation of macroscopic adhesion intensity found statistically significant differences between the groups. The sugammadex group was observed to have fewer adhesions in a statistically significant manner compared with the control group (p < 0.05). In our experimental intra-abdominal adhesion model in rats, we observed that sugammadex prevented postoperative intra-abdominal adhesions. |
topic |
Experimental study Peritoneal adhesion Rats Sugammadex Surgery |
url |
http://www.sciencedirect.com/science/article/pii/S1607551X15001631 |
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