Shavenbaby and Yorkie mediate Hippo signaling to protect adult stem cells from apoptosis

Shavenbaby and Yorkie mediate Hippo signaling to protect adult stem cells from apoptosis

Organ regeneration by stem cells is required to compensate for tissue damage during aging, although how stem cells are maintained in adulthood is poorly understood. Here, the authors show in Drosophila that Shavenbaby interacts with Yorkie, a mediator of Hippo signalling, to ensure adult stem cell s...

Full description

Bibliographic Details
Main Authors: Jérôme Bohère, Alexandra Mancheno-Ferris, Sandy Al Hayek, Jennifer Zanet, Philippe Valenti, Kohsuke Akino, Yuya Yamabe, Sachi Inagaki, Hélène Chanut-Delalande, Serge Plaza, Yuji Kageyama, Dani Osman, Cédric Polesello, François Payre
Format: Article
Language:English
Published: Nature Publishing Group 2018-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-07569-0
id doaj-5930b17e296243aa9c62f8dbc7b2397f
record_format Article
spelling doaj-5930b17e296243aa9c62f8dbc7b2397f2021-05-11T10:22:22ZengNature Publishing GroupNature Communications2041-17232018-11-019111210.1038/s41467-018-07569-0Shavenbaby and Yorkie mediate Hippo signaling to protect adult stem cells from apoptosisJérôme Bohère0Alexandra Mancheno-Ferris1Sandy Al Hayek2Jennifer Zanet3Philippe Valenti4Kohsuke Akino5Yuya Yamabe6Sachi Inagaki7Hélène Chanut-Delalande8Serge Plaza9Yuji Kageyama10Dani Osman11Cédric Polesello12François Payre13Centre de Biologie du Développement (CBD), Centre de Biologie Intégrative (CBI), Université de ToulouseCentre de Biologie du Développement (CBD), Centre de Biologie Intégrative (CBI), Université de ToulouseCentre de Biologie du Développement (CBD), Centre de Biologie Intégrative (CBI), Université de ToulouseCentre de Biologie du Développement (CBD), Centre de Biologie Intégrative (CBI), Université de ToulouseCentre de Biologie du Développement (CBD), Centre de Biologie Intégrative (CBI), Université de ToulouseDepartment of Biology, Graduate School of ScienceDepartment of Biology, Graduate School of ScienceBiosignal Research Center, Kobe UniversityCentre de Biologie du Développement (CBD), Centre de Biologie Intégrative (CBI), Université de ToulouseCentre de Biologie du Développement (CBD), Centre de Biologie Intégrative (CBI), Université de ToulouseDepartment of Biology, Graduate School of ScienceFaculty of Sciences III, Lebanese UniversityCentre de Biologie du Développement (CBD), Centre de Biologie Intégrative (CBI), Université de ToulouseCentre de Biologie du Développement (CBD), Centre de Biologie Intégrative (CBI), Université de ToulouseOrgan regeneration by stem cells is required to compensate for tissue damage during aging, although how stem cells are maintained in adulthood is poorly understood. Here, the authors show in Drosophila that Shavenbaby interacts with Yorkie, a mediator of Hippo signalling, to ensure adult stem cell survival.https://doi.org/10.1038/s41467-018-07569-0
collection DOAJ
language English
format Article
sources DOAJ
author Jérôme Bohère
Alexandra Mancheno-Ferris
Sandy Al Hayek
Jennifer Zanet
Philippe Valenti
Kohsuke Akino
Yuya Yamabe
Sachi Inagaki
Hélène Chanut-Delalande
Serge Plaza
Yuji Kageyama
Dani Osman
Cédric Polesello
François Payre
spellingShingle Jérôme Bohère
Alexandra Mancheno-Ferris
Sandy Al Hayek
Jennifer Zanet
Philippe Valenti
Kohsuke Akino
Yuya Yamabe
Sachi Inagaki
Hélène Chanut-Delalande
Serge Plaza
Yuji Kageyama
Dani Osman
Cédric Polesello
François Payre
Shavenbaby and Yorkie mediate Hippo signaling to protect adult stem cells from apoptosis
Nature Communications
author_facet Jérôme Bohère
Alexandra Mancheno-Ferris
Sandy Al Hayek
Jennifer Zanet
Philippe Valenti
Kohsuke Akino
Yuya Yamabe
Sachi Inagaki
Hélène Chanut-Delalande
Serge Plaza
Yuji Kageyama
Dani Osman
Cédric Polesello
François Payre
author_sort Jérôme Bohère
title Shavenbaby and Yorkie mediate Hippo signaling to protect adult stem cells from apoptosis
title_short Shavenbaby and Yorkie mediate Hippo signaling to protect adult stem cells from apoptosis
title_full Shavenbaby and Yorkie mediate Hippo signaling to protect adult stem cells from apoptosis
title_fullStr Shavenbaby and Yorkie mediate Hippo signaling to protect adult stem cells from apoptosis
title_full_unstemmed Shavenbaby and Yorkie mediate Hippo signaling to protect adult stem cells from apoptosis
title_sort shavenbaby and yorkie mediate hippo signaling to protect adult stem cells from apoptosis
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-11-01
description Organ regeneration by stem cells is required to compensate for tissue damage during aging, although how stem cells are maintained in adulthood is poorly understood. Here, the authors show in Drosophila that Shavenbaby interacts with Yorkie, a mediator of Hippo signalling, to ensure adult stem cell survival.
url https://doi.org/10.1038/s41467-018-07569-0
work_keys_str_mv AT jeromebohere shavenbabyandyorkiemediatehipposignalingtoprotectadultstemcellsfromapoptosis
AT alexandramanchenoferris shavenbabyandyorkiemediatehipposignalingtoprotectadultstemcellsfromapoptosis
AT sandyalhayek shavenbabyandyorkiemediatehipposignalingtoprotectadultstemcellsfromapoptosis
AT jenniferzanet shavenbabyandyorkiemediatehipposignalingtoprotectadultstemcellsfromapoptosis
AT philippevalenti shavenbabyandyorkiemediatehipposignalingtoprotectadultstemcellsfromapoptosis
AT kohsukeakino shavenbabyandyorkiemediatehipposignalingtoprotectadultstemcellsfromapoptosis
AT yuyayamabe shavenbabyandyorkiemediatehipposignalingtoprotectadultstemcellsfromapoptosis
AT sachiinagaki shavenbabyandyorkiemediatehipposignalingtoprotectadultstemcellsfromapoptosis
AT helenechanutdelalande shavenbabyandyorkiemediatehipposignalingtoprotectadultstemcellsfromapoptosis
AT sergeplaza shavenbabyandyorkiemediatehipposignalingtoprotectadultstemcellsfromapoptosis
AT yujikageyama shavenbabyandyorkiemediatehipposignalingtoprotectadultstemcellsfromapoptosis
AT daniosman shavenbabyandyorkiemediatehipposignalingtoprotectadultstemcellsfromapoptosis
AT cedricpolesello shavenbabyandyorkiemediatehipposignalingtoprotectadultstemcellsfromapoptosis
AT francoispayre shavenbabyandyorkiemediatehipposignalingtoprotectadultstemcellsfromapoptosis
_version_ 1721448277755297792

Similar Items