The Optimal First-Line Therapy of Helicobacter pylori Infection in Year 2012
This paper reviews the literature about first-line therapies for H. pylori infection in recent years. First-line therapies are facing a challenge because of increasing treatment failure due to elevated antibiotics resistance. Several new treatment strategies that recently emerged to overcome antibio...
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Series: | Gastroenterology Research and Practice |
Online Access: | http://dx.doi.org/10.1155/2012/168361 |
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doaj-5930e418a7a34fe5953790af0151b16d2020-11-24T21:25:06ZengHindawi LimitedGastroenterology Research and Practice1687-61211687-630X2012-01-01201210.1155/2012/168361168361The Optimal First-Line Therapy of Helicobacter pylori Infection in Year 2012Chao-Hung Kuo0Fu-Chen Kuo1Huang-Ming Hu2Chung-Jung Liu3Sophie S. W. Wang4Yen-Hsu Chen5Ming-Chia Hsieh6Ming-Feng Hou7Deng-Chyang Wu8Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung City 807, TaiwanDepartment of Health Management, I-Shou University, E-Da Hospital, Kaohsiung County 824, TaiwanDivision of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung City 807, TaiwanDivision of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung City 807, TaiwanDivision of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung City 807, TaiwanDivision of Infectious Diseases, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung City 807, TaiwanDivision of Endocrinology and Metabolism, Department of Internal Medicine, Changhua Christian Hospital, Changhua 500, TaiwanCancer Center, Kaohsiung Medical University Hospital, Kaohsiung City 807, TaiwanDivision of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung City 807, TaiwanThis paper reviews the literature about first-line therapies for H. pylori infection in recent years. First-line therapies are facing a challenge because of increasing treatment failure due to elevated antibiotics resistance. Several new treatment strategies that recently emerged to overcome antibiotic resistance have been surveyed. Alternative first-line therapies include bismuth-containing quadruple therapy, sequential therapy, concomitant therapy, and hybrid therapy. Levofloxacin-based therapy shows impressive efficacy but might be employed as rescue treatment due to rapidly raising resistance. Rifabutin-based therapy is also regarded as a rescue therapy. Several factors including antibiotics resistance, patient compliance, and CYP 2C19 genotypes could influence the outcome. Clinicians should use antibiotics according to local reports. It is recommended that triple therapy should not be used in areas with high clarithromycin resistance or dual clarithromycin and metronidazole resistance.http://dx.doi.org/10.1155/2012/168361 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Chao-Hung Kuo Fu-Chen Kuo Huang-Ming Hu Chung-Jung Liu Sophie S. W. Wang Yen-Hsu Chen Ming-Chia Hsieh Ming-Feng Hou Deng-Chyang Wu |
spellingShingle |
Chao-Hung Kuo Fu-Chen Kuo Huang-Ming Hu Chung-Jung Liu Sophie S. W. Wang Yen-Hsu Chen Ming-Chia Hsieh Ming-Feng Hou Deng-Chyang Wu The Optimal First-Line Therapy of Helicobacter pylori Infection in Year 2012 Gastroenterology Research and Practice |
author_facet |
Chao-Hung Kuo Fu-Chen Kuo Huang-Ming Hu Chung-Jung Liu Sophie S. W. Wang Yen-Hsu Chen Ming-Chia Hsieh Ming-Feng Hou Deng-Chyang Wu |
author_sort |
Chao-Hung Kuo |
title |
The Optimal First-Line Therapy of Helicobacter pylori Infection in Year 2012 |
title_short |
The Optimal First-Line Therapy of Helicobacter pylori Infection in Year 2012 |
title_full |
The Optimal First-Line Therapy of Helicobacter pylori Infection in Year 2012 |
title_fullStr |
The Optimal First-Line Therapy of Helicobacter pylori Infection in Year 2012 |
title_full_unstemmed |
The Optimal First-Line Therapy of Helicobacter pylori Infection in Year 2012 |
title_sort |
optimal first-line therapy of helicobacter pylori infection in year 2012 |
publisher |
Hindawi Limited |
series |
Gastroenterology Research and Practice |
issn |
1687-6121 1687-630X |
publishDate |
2012-01-01 |
description |
This paper reviews the literature about first-line therapies for H. pylori infection in recent years. First-line therapies are facing a challenge because of increasing treatment failure due to elevated antibiotics resistance. Several new treatment strategies that recently emerged to overcome antibiotic resistance have been surveyed. Alternative first-line therapies include bismuth-containing quadruple therapy, sequential therapy, concomitant therapy, and hybrid therapy. Levofloxacin-based therapy shows impressive efficacy but might be employed as rescue treatment due to rapidly raising resistance. Rifabutin-based therapy is also regarded as a rescue therapy. Several factors including antibiotics resistance, patient compliance, and CYP 2C19 genotypes could influence the outcome. Clinicians should use antibiotics according to local reports. It is recommended that triple therapy should not be used in areas with high clarithromycin resistance or dual clarithromycin and metronidazole resistance. |
url |
http://dx.doi.org/10.1155/2012/168361 |
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