GABAergic Transmission in the Basolateral Amygdala Differentially Modulates Plasticity in the Dentate Gyrus and the CA1 Areas
The term “metaplasticity” is used to describe changes in synaptic plasticity sensitivity following an electrical, biochemical, or behavioral priming stimulus. For example, priming the basolateral amygdala (BLA) enhances long-term potentiation (LTP) in the dentate gyrus (DG) but decreases LTP in the...
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doaj-59323a63372e4d58b870f1a75c4f5df72020-11-25T02:13:43ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-05-01213786378610.3390/ijms21113786GABAergic Transmission in the Basolateral Amygdala Differentially Modulates Plasticity in the Dentate Gyrus and the CA1 AreasRose-Marie Vouimba0Rachel Anunu1Gal Richter-Levin2Université de Bordeaux and Institut de Neurosciences Cognitives et Intégratives d'Aquitaine, CNRS, Unité Mixte de Recherche 5287, Allée Geoffroy Saint-Hilaire, CS50023, 33615 PESSAC CEDEX, FranceDepartment of Psychology, University of Haifa, 3498838 Haifa, IsraelDepartment of Psychology, University of Haifa, 3498838 Haifa, IsraelThe term “metaplasticity” is used to describe changes in synaptic plasticity sensitivity following an electrical, biochemical, or behavioral priming stimulus. For example, priming the basolateral amygdala (BLA) enhances long-term potentiation (LTP) in the dentate gyrus (DG) but decreases LTP in the CA1. However, the mechanisms underlying these metaplastic effects are only partly understood. Here, we examined whether the mechanism underlying these effects of BLA priming involves intra-BLA GABAergic neurotransmission. Low doses of muscimol, a GABA<sub>A</sub> receptor (GABA<sub>A</sub>R) agonist, were microinfused into the rat BLA before or after BLA priming. Our findings show that BLA GABA<sub>A</sub>R activation via muscimol mimicked the previously reported effects of electrical BLA priming on LTP in the perforant path and the ventral hippocampal commissure-CA1 pathways, decreasing CA1 LTP and increasing DG LTP. Furthermore, muscimol application before or after tetanic stimulation of the ventral hippocampal commissure-CA1 pathways attenuated the BLA priming-induced decrease in CA1 LTP. In contrast, muscimol application after tetanic stimulation of the perforant path attenuated the BLA priming-induced increase in DG LTP. The data indicate that GABA<sub>A</sub>R activation mediates metaplastic effects of the BLA on plasticity in the CA1 and the DG, but that the same GABA<sub>A</sub>R activation induces an intra-BLA form of metaplasticity, which alters the way BLA priming may modulate plasticity in other brain regions. These results emphasize the need for developing a dynamic model of BLA modulation of plasticity, a model that may better capture processes underlying memory alterations associated with emotional arousing or stressful events.https://www.mdpi.com/1422-0067/21/11/3786basolateral amygdalaCA1dentate gyrusGABAmetaplasticitysynaptic plasticity |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Rose-Marie Vouimba Rachel Anunu Gal Richter-Levin |
spellingShingle |
Rose-Marie Vouimba Rachel Anunu Gal Richter-Levin GABAergic Transmission in the Basolateral Amygdala Differentially Modulates Plasticity in the Dentate Gyrus and the CA1 Areas International Journal of Molecular Sciences basolateral amygdala CA1 dentate gyrus GABA metaplasticity synaptic plasticity |
author_facet |
Rose-Marie Vouimba Rachel Anunu Gal Richter-Levin |
author_sort |
Rose-Marie Vouimba |
title |
GABAergic Transmission in the Basolateral Amygdala Differentially Modulates Plasticity in the Dentate Gyrus and the CA1 Areas |
title_short |
GABAergic Transmission in the Basolateral Amygdala Differentially Modulates Plasticity in the Dentate Gyrus and the CA1 Areas |
title_full |
GABAergic Transmission in the Basolateral Amygdala Differentially Modulates Plasticity in the Dentate Gyrus and the CA1 Areas |
title_fullStr |
GABAergic Transmission in the Basolateral Amygdala Differentially Modulates Plasticity in the Dentate Gyrus and the CA1 Areas |
title_full_unstemmed |
GABAergic Transmission in the Basolateral Amygdala Differentially Modulates Plasticity in the Dentate Gyrus and the CA1 Areas |
title_sort |
gabaergic transmission in the basolateral amygdala differentially modulates plasticity in the dentate gyrus and the ca1 areas |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1661-6596 1422-0067 |
publishDate |
2020-05-01 |
description |
The term “metaplasticity” is used to describe changes in synaptic plasticity sensitivity following an electrical, biochemical, or behavioral priming stimulus. For example, priming the basolateral amygdala (BLA) enhances long-term potentiation (LTP) in the dentate gyrus (DG) but decreases LTP in the CA1. However, the mechanisms underlying these metaplastic effects are only partly understood. Here, we examined whether the mechanism underlying these effects of BLA priming involves intra-BLA GABAergic neurotransmission. Low doses of muscimol, a GABA<sub>A</sub> receptor (GABA<sub>A</sub>R) agonist, were microinfused into the rat BLA before or after BLA priming. Our findings show that BLA GABA<sub>A</sub>R activation via muscimol mimicked the previously reported effects of electrical BLA priming on LTP in the perforant path and the ventral hippocampal commissure-CA1 pathways, decreasing CA1 LTP and increasing DG LTP. Furthermore, muscimol application before or after tetanic stimulation of the ventral hippocampal commissure-CA1 pathways attenuated the BLA priming-induced decrease in CA1 LTP. In contrast, muscimol application after tetanic stimulation of the perforant path attenuated the BLA priming-induced increase in DG LTP. The data indicate that GABA<sub>A</sub>R activation mediates metaplastic effects of the BLA on plasticity in the CA1 and the DG, but that the same GABA<sub>A</sub>R activation induces an intra-BLA form of metaplasticity, which alters the way BLA priming may modulate plasticity in other brain regions. These results emphasize the need for developing a dynamic model of BLA modulation of plasticity, a model that may better capture processes underlying memory alterations associated with emotional arousing or stressful events. |
topic |
basolateral amygdala CA1 dentate gyrus GABA metaplasticity synaptic plasticity |
url |
https://www.mdpi.com/1422-0067/21/11/3786 |
work_keys_str_mv |
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1724903504272687104 |