Safety and immunogenicity of a recombinant Plasmodium falciparum AMA1 malaria vaccine adjuvanted with Alhydrogel, Montanide ISA 720 or AS02.
Plasmodium falciparum Apical Membrane Antigen 1 (PfAMA1) is a candidate vaccine antigen expressed by merozoites and sporozoites. It plays a key role in red blood cell and hepatocyte invasion that can be blocked by antibodies.We assessed the safety and immunogenicity of recombinant PfAMA1 in a dose-e...
Main Authors: | Meta Roestenberg, Ed Remarque, Erik de Jonge, Rob Hermsen, Hildur Blythman, Odile Leroy, Egeruan Imoukhuede, Soren Jepsen, Opokua Ofori-Anyinam, Bart Faber, Clemens H M Kocken, Miranda Arnold, Vanessa Walraven, Karina Teelen, Will Roeffen, Quirijn de Mast, W Ripley Ballou, Joe Cohen, Marie Claude Dubois, Stéphane Ascarateil, Andre van der Ven, Alan Thomas, Robert Sauerwein |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2008-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC2602972?pdf=render |
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