Nivolumab in relapsed/refractory Hodgkin Lymphoma patients, single center experiences
Hodgkin Lymphoma (HL) is one of the hematological malignancies where the inflammatory process is quite high, immunotherapy agents are frequently used and successful results are obtained. We aimed to show real-life data on health outcomes in adult patients withrecurrent or refractory HL who received...
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doaj-593c7efd493745678c54c056a0755e4f2021-03-24T11:50:49ZengSociety of TURAZ AKADEMI Medicine Science2147-06342020-12-01941004710.5455/medscience.2020.07.125119705Nivolumab in relapsed/refractory Hodgkin Lymphoma patients, single center experiencesRamazan Acar0Murat Yildirim1University of Health Science, Gulhane School of Medicine, Department of Medical Oncology University of Health Science, Gulhane School of Medicine, Department of HematologyHodgkin Lymphoma (HL) is one of the hematological malignancies where the inflammatory process is quite high, immunotherapy agents are frequently used and successful results are obtained. We aimed to show real-life data on health outcomes in adult patients withrecurrent or refractory HL who received nivolumab (immune checkpoint inhibitory). We analyzed the data of 15 patients who received nivolumab after or before high dose chemotherapy (HDCT) for relapsed or refractory HL from 2010 to 2020. Overall response rate (ORR), overall survival (OS) and progression-free survival (PFS) of the patients were evaluated. 15 patients were observed in this study. The mean age of the study group was 26.9 ±10.9 years. 40% of the patients were female (n=6). Overall response rate (ORR) was 80 %. The median overall survival (OS) and progression-free survival (PFS) were 50.7 months (95% CI: 37.2-64.2) and 46.2 months (95% CI: 32.9-59.5), respectively. 1-year OS and PFS rates were 90.9% and %88.2, respectively. 5-year OS rate was 67.3%. Nivolumab treatment is a safe, effective and excellent treatment option for relapsed or refractory adult HL patients with a good ORR, OS and PFS time. [Med-Science 2020; 9(4.000): 1004-7]http://www.ejmanager.com/fulltextpdf.php?mno=119705nivolumabhodgkin lymphomaimmunotherapy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ramazan Acar Murat Yildirim |
spellingShingle |
Ramazan Acar Murat Yildirim Nivolumab in relapsed/refractory Hodgkin Lymphoma patients, single center experiences Medicine Science nivolumab hodgkin lymphoma immunotherapy |
author_facet |
Ramazan Acar Murat Yildirim |
author_sort |
Ramazan Acar |
title |
Nivolumab in relapsed/refractory Hodgkin Lymphoma patients, single center experiences |
title_short |
Nivolumab in relapsed/refractory Hodgkin Lymphoma patients, single center experiences |
title_full |
Nivolumab in relapsed/refractory Hodgkin Lymphoma patients, single center experiences |
title_fullStr |
Nivolumab in relapsed/refractory Hodgkin Lymphoma patients, single center experiences |
title_full_unstemmed |
Nivolumab in relapsed/refractory Hodgkin Lymphoma patients, single center experiences |
title_sort |
nivolumab in relapsed/refractory hodgkin lymphoma patients, single center experiences |
publisher |
Society of TURAZ AKADEMI |
series |
Medicine Science |
issn |
2147-0634 |
publishDate |
2020-12-01 |
description |
Hodgkin Lymphoma (HL) is one of the hematological malignancies where the inflammatory process is quite high, immunotherapy agents are frequently used and successful results are obtained. We aimed to show real-life data on health outcomes in adult patients withrecurrent or refractory HL who received nivolumab (immune checkpoint inhibitory). We analyzed the data of 15 patients who received nivolumab after or before high dose chemotherapy (HDCT) for relapsed or refractory HL from 2010 to 2020. Overall response rate (ORR), overall survival (OS) and progression-free survival (PFS) of the patients were evaluated. 15 patients were observed in this study. The mean age of the study group was 26.9 ±10.9 years. 40% of the patients were female (n=6). Overall response rate (ORR) was 80 %. The median overall survival (OS) and progression-free survival (PFS) were 50.7 months (95% CI: 37.2-64.2) and 46.2 months (95% CI: 32.9-59.5), respectively. 1-year OS and PFS rates were 90.9% and %88.2, respectively. 5-year OS rate was 67.3%. Nivolumab treatment is a safe, effective and excellent treatment option for relapsed or refractory adult HL patients with a good ORR, OS and PFS time. [Med-Science 2020; 9(4.000): 1004-7] |
topic |
nivolumab hodgkin lymphoma immunotherapy |
url |
http://www.ejmanager.com/fulltextpdf.php?mno=119705 |
work_keys_str_mv |
AT ramazanacar nivolumabinrelapsedrefractoryhodgkinlymphomapatientssinglecenterexperiences AT muratyildirim nivolumabinrelapsedrefractoryhodgkinlymphomapatientssinglecenterexperiences |
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